Benoît Champigneulle
A5071928179- High Altitude and Hypoxia
- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neuroscience of respiration and sleep
- Travel-related health issues
- Airway Management and Intubation Techniques
- Intensive Care Unit Cognitive Disorders
- Organ Transplantation Techniques and Outcomes
- Mechanical Circulatory Support Devices
- Organ Donation and Transplantation
- Anesthesia and Sedative Agents
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Anesthesia and Pain Management
- Clinical Nutrition and Gastroenterology
- Family and Patient Care in Intensive Care Units
- Tracheal and airway disorders
- Heart Rate Variability and Autonomic Control
- Cardiac, Anesthesia and Surgical Outcomes
- Grief, Bereavement, and Mental Health
- Trauma and Emergency Care Studies
- Sepsis Diagnosis and Treatment
- Erythrocyte Function and Pathophysiology
- Cardiovascular and Diving-Related Complications
- Liver Disease and Transplantation
Université Grenoble Alpes
2021-2025
Inserm
2015-2024
Centre Hospitalier Universitaire de Grenoble
2020-2024
Assistance Publique – Hôpitaux de Paris
2014-2023
Université Paris Cité
2012-2023
Hôpital Européen Georges-Pompidou
2014-2023
Hôpital Européen
2017-2022
Physiopathologie et Epidémiologie des Maladies Respiratoires
2020-2022
Hôpital Nord
2022
Hôpital Cochin
2012-2019
<h3>Importance</h3> Tracheal intubation is one of the most commonly performed and high-risk interventions in critically ill patients. Limited information available on adverse peri-intubation events. <h3>Objective</h3> To evaluate incidence nature events to assess current practice <h3>Design, Setting, Participants</h3> The International Observational Study Understand Impact Best Practices Airway Management Critically Ill Patients (INTUBE) study was an international, multicenter, prospective...
In the intensive care unit (ICU), orotracheal intubation can be associated with increased risk of complications because patient may acutely unstable, requiring prompt intervention, often by a practitioner nonexpert skills. Video laryngoscopy decrease this improving glottis visualization.To determine whether video increases frequency successful first-pass compared direct in ICU patients.Randomized clinical trial 371 adults while being treated at 7 ICUs France between May 2015 and January...
It is well recognized that sleep severely disturbed in patients intensive care units (ICU) and this can compromise their rehabilitation potential. However, it still difficult to objectively assess quantity quality the determinants of disturbance remain unclear. The aim study was therefore evaluate carefully impact ICU sound intensity levels sources on patients' over a 24-h period.Sleep were recorded 11 intubated who met criteria. Sleep using miniaturized multi-channel ambulatory recording...
Red blood cell (RBC) metabolic reprogramming upon exposure to high altitude contributes physiological human adaptations hypoxia, a multifaceted process critical health and disease. To delve into the molecular underpinnings of this phenomenon, first, we performed multi-omics analysis RBCs from six lowlanders after high-altitude with longitudinal sampling at baseline, ascent 5,100 m descent sea level. Results highlighted an association between erythrocyte levels 2,3-bisphosphoglycerate (BPG),...
To describe the characteristics, management, and outcome of patients admitted to ICUs for pheochromocytoma crisis.A 16-year multicenter retrospective study.Fifteen university nonuniversity in France.Patients ICU crisis.None.We included 34 with a median age 46 years (40-54 yr); 65% were males. At admission, Sequential Organ Failure Assessment score was 8 (4-12) Simplified Acute Physiology Score II 49.5 (27-70). The left ventricular ejection fraction consistently decreased value 30% (15-40%)....
High altitude exposes humans to hypobaric hypoxia, which induces various physiological and molecular changes. Recent studies point toward interaction between circadian rhythms the hypoxic response, yet their human relevance is lacking. Here, we examine effect of different high altitudes in conjunction with time day on whole-blood transcriptome upon an expedition highest city world, La Rinconada, Peru, 5,100 m above sea level. We find that vastly affects blood and, unexpectedly, does not...
A number of indigenous populations have resided at high-altitude for generations, resulting in various phenotypical adaptations promoting successful adaptation. While many these been investigated adults, little is known regarding how children residing high-altitudes adapt, particularly with regards to the cerebrovasculature. Under hypoxic environments, compensatory changes cerebral blood flow (CBF) are necessary couple oxygen delivery metabolic demand face reduced availability. In this...
The overall outcome of septic shock has been recently improved. We sought to determine whether this survival gain extends the high-risk subgroup patients with cirrhosis.Cirrhotic admitted a medical intensive care unit (ICU) during two consecutive periods (1997-2004 and 2005-2010) were retrospectively studied.Forty-seven 42 cirrhotic presented in 1997-2004 2005-2010, respectively. recent period differed from previous one by implementation adjuvant treatments including albumin infusion as...
Family members of patients who die in the ICU often remain with unanswered questions and suffer from lack closure. A letter condolence may help bereaved relatives, but little is known about their experience receiving such a letter. The objective study was to understand family members' condolence.Qualitative using interviews received letters written by these team. This designed provide insight into results larger randomized, controlled, multicenter study.Twenty-two ICUs France.Family lost...