A5036937215- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience of respiration and sleep
- High Altitude and Hypoxia
- Cardiovascular Health and Disease Prevention
- Optical Imaging and Spectroscopy Techniques
- Heart Rate Variability and Autonomic Control
- Nitric Oxide and Endothelin Effects
- Health Literacy and Information Accessibility
- Cardiovascular and Diving-Related Complications
- Heme Oxygenase-1 and Carbon Monoxide
- Maternal Mental Health During Pregnancy and Postpartum
- Respiratory Support and Mechanisms
- Social Media in Health Education
- Spaceflight effects on biology
- Mitochondrial Function and Pathology
- Thermal Regulation in Medicine
- Mobile Health and mHealth Applications
- Climate Change and Health Impacts
- Cardiovascular Disease and Adiposity
- Hemodynamic Monitoring and Therapy
- Cerebrovascular and Carotid Artery Diseases
- Thermoregulation and physiological responses
- Mental Health Treatment and Access
- Neonatal and fetal brain pathology
- Acute Ischemic Stroke Management
Cardiff Metropolitan University
2025
University of British Columbia
2018-2023
Okanagan University College
2018-2023
Preclinical models have demonstrated that nitric oxide is a key component of neurovascular coupling; this has yet to be translated humans. We conducted two separate protocols utilizing intravenous infusion synthase inhibitor and isovolumic haemodilution assess the influence on coupling in Isovolumic did not alter coupling. Intravenous reduced response by ∼30%, indicating integral humans.Nitric vital signalling molecule preclinical models, mechanisms underlying (NVC) humans elucidated. To...
Cerebral hypoxic vasodilation is poorly understood in humans, which undermines the development of therapeutics to optimize cerebral oxygen delivery. Across four investigations (total n = 195) we investigated role nitric oxide (NO) and hemoglobin-based S-nitrosothiol (RSNO) nitrite ([Formula: see text]) signaling regulation vasodilation. We conducted hemodilution (n 10) NO synthase inhibition experiments 11) as well hemoglobin desaturation protocols, wherein measured blood flow (CBF),...
Dealing with health information and taking care of one’s own are key aspects literacy a difficulty for nearly half the population in Europe. Limited often results poorer outcomes. Health is fundamental determinant, its improvement provides great potential addressing public challenges. organizations play an important role improving population’s literacy. literate facilitate access, understanding use decrease demands complexities system. Few efforts have been taken so far to promote...
What is the central question of this study? In study, we investigated intracranial cerebrovascular and ventilatory reactivity to 6% CO2 in children adults explored dynamic onset responses. main finding its importance? We showed that was similar adults, but blood velocity response markedly attenuated children. Sex differences were apparent, with greater increases females lower adult females. Our study confirms importance investigating responses when assessing influence development on...
New Findings What is the central question of this study? Do differing magnitudes ventilation influence cerebrovascular CO 2 reactivity and cerebral blood flow response to increases in arterial carbon dioxide? main finding its importance? While a greater ventilation, through voluntary hyperventilation, associated with higher anterior during dioxide breathing, elevated due pressure not per se . A does global or posterior breathing. Cerebrovascular influenced by an individual's ventilatory...
A number of indigenous populations have resided at high-altitude for generations, resulting in various phenotypical adaptations promoting successful adaptation. While many these been investigated adults, little is known regarding how children residing high-altitudes adapt, particularly with regards to the cerebrovasculature. Under hypoxic environments, compensatory changes cerebral blood flow (CBF) are necessary couple oxygen delivery metabolic demand face reduced availability. In this...
We sought to make the first comparisons of duplex Doppler ultrasonography-derived measures cerebral blood flow during exercise in young and older individuals assess whether healthy aging influences effect on neurovascular coupling (NVC) vascular reactivity changes carbon dioxide (CVRco 2 ). In 10 (23 ± yr; mean SD) 9 (66 3 yr) individuals, internal carotid artery (ICA) vertebral (VA) flows were concurrently measured, along with middle posterior velocity (MCAv PCAv Measures made at rest leg...
Iron acts as a cofactor in the stabilization of hypoxic-inducible factor family, and plays an influential role modulation hypoxic pulmonary vasoconstriction. It is uncertain whether iron regulation altered lowlanders during either (1) ascent to high altitude, or (2) following partial acclimatization, when compared high-altitude adapted Sherpa. During 5050 m, rise artery systolic pressure (PASP) was blunted Sherpa, lowlanders; however, upon arrival PASP levels were comparable both groups, but...
Exercise has been shown to induce cerebrovascular adaptations. However, the underlying temporal dynamics are poorly understood, and regional variation in vascular response exercise observed large cerebral arteries. Here, we sought measure effects of a single 20-min session moderate-intensity one hour period immediately following cessation. We employed transcranial Doppler (TCD) ultrasonography blood flow velocity (CBFV) middle artery (MCAv) posterior (PCAv) before, during, exercise....
It was unknown whether respiratory alkalosis impacts the global cerebral metabolic response as well pro-oxidation and inflammatory in passive hyperthermia. This study demonstrated that rate increased by ∼20% with hyperthermia of up to +2°C oesophageal temperature, this unaffected alkalosis. Additionally, increase metabolism did not significantly impact net release oxidative markers. These data indicate heating core temperature healthy young men is enough confer a major burden on brain, but...
Changes in haematocrit influence nitric oxide signalling through alterations shear stress stimuli and haemoglobin scavenging of oxide; these two regulatory factors have not been assessed simultaneously Isovolumic haemodilution led to a marked increase brachial artery flow-mediated dilatation humans The occurred the face an unaltered stimulus for vasodilatation reduced resting steady-state levels blood Collectively, our data point towards as key factor highlight importance simultaneous...
This study investigated the influence of acute reductions in arterial O2 content (CaO2) via isovolumic haemodilution on global cerebral blood flow (gCBF) and cerebrovascular CO2 reactivity (CVR) 11 healthy males (age; 28 ± 7 years: body mass index; 23 2 kg/m2). Radial artery internal jugular vein catheters provided measurement pressure gases, quantification metabolism, washout, trans-cerebral nitrite exchange (ozone based chemiluminescence). Prior to following haemodilution, partial (PaCO2)...
Background: Mental health literacy (MHL) promises to be an important factor for public by enabling people take responsibility their own mental health. To date, there is no measurement tool that allows the assessment of a comprehensive understanding MHL as part (HL). Nonetheless, widely used Health Literacy Survey European Questionnaire 47 (HLS-EU-Q47) includes items assessing at least some MHL-aspects in context HL. The present study aimed investigating how these are related HL, behavior and...
Intracranial blood velocity reactivity to a steady-state hypercapnic stimulus has been shown be similar in children and adults, but the onset response hypercapnia is slower child. Given vasodilatory effect of on cerebrovasculature, assessment vessel diameter, flow are vital fully elucidate whether temporal differs versus adults. Assessment internal carotid artery (ICA) diameter (ICAd), (ICAv), volumetric (QICA), shear rate (ICASR) 4 min challenge was completed (n = 14, 8 girls; 9.8 ± 0.7...
What is the central question of study? Does use antioxidants alter cerebrovascular function and blood flow at sea level (344 m) and/or high altitude (5050 m)? main finding its importance? This first study to investigate whether antioxidant administration alters regulation in response hypercapnia, acute hypoxia chronic healthy humans. We demonstrate that an dose does not or after 12 days m).Hypoxia associated with increase systemic cerebral formation free radicals reactants may be linked...
Abstract The purpose of this study was to examine the effect an acute bout prolonged sitting with and without exercise breaks on cerebrovascular function in 7‐ 13‐year‐old children. Forty‐two children adolescents were recruited a crossover trial, 15 girls (mean age 10.1 ± 2.5 years) 16 boys 10.5 1.3 completing two trial conditions: SIT, uninterrupted for 3 h CYCLE, interrupted hourly 10‐min moderate intensity break. Cerebrovascular measured Pre Post SIT CYCLE from blood flow (), diameter,...
Cerebral blood flow is known to change with age; however, assessing these age-related changes complex and requires consideration of pubertal status. This, our knowledge, the first study investigate influence sex maturation on resting cervical artery hemodynamics subsequently explore associations physical activity sedentary behavior in healthy children adolescents. Our findings suggest that habitual may youth, independent activity, maturation, sex.
Understanding the process of successful adaptation to high altitude provides valuable insight into pathogenesis conditions associated with impaired oxygen uptake and utilization. Prepubertal children residing at low show a reduced cerebrovascular response exercise in comparison adults, transient uncoupling cerebral blood flow changes partial pressure end-tidal CO2 (PETCO2); however, little is known about high-altitude native children. We sought compare hemodynamic acute between prepubertal...