A5082583678- Cardiovascular Health and Disease Prevention
- Heart Rate Variability and Autonomic Control
- Cardiovascular and exercise physiology
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- High Altitude and Hypoxia
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Optical Imaging and Spectroscopy Techniques
- Neurology and Historical Studies
- Cardiovascular and Diving-Related Complications
- Oil and Gas Production Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Hydraulic Fracturing and Reservoir Analysis
- Reservoir Engineering and Simulation Methods
- Aortic aneurysm repair treatments
- Mitochondrial Function and Pathology
- Neonatal and fetal brain pathology
- Blood Pressure and Hypertension Studies
- Thermoregulation and physiological responses
- Nutritional Studies and Diet
- Neuroscience of respiration and sleep
- Hip and Femur Fractures
Cardiff Metropolitan University
2018-2025
Baker Heart and Diabetes Institute
2024
Epistem (United Kingdom)
2013
Abstract Conventionally, automated history matching methods operated on a single number (the misfit or match quality) which is obtained by summing the least square misfits for all quantities of interest in match. Multi-objective allows algorithm to be guided (usually groups of) quality components, with overall probability determined components at end. This feature encourages diversity match, as can trade off matches one area against good fits elsewhere, and has also been shown speed up some...
A number of indigenous populations have resided at high-altitude for generations, resulting in various phenotypical adaptations promoting successful adaptation. While many these been investigated adults, little is known regarding how children residing high-altitudes adapt, particularly with regards to the cerebrovasculature. Under hypoxic environments, compensatory changes cerebral blood flow (CBF) are necessary couple oxygen delivery metabolic demand face reduced availability. In this...
Cardiovascular and haematological adaptations to endurance training facilitate greater maximal oxygen consumption ( V̇O2max${\dot{V}_{{{\rm{O}}_{\rm{2}}}{\rm{max}}}}$ ), such may be augmented following puberty. Therefore, we compared left ventricular (LV) morphology (echocardiography), blood volume, haemoglobin (Hb) mass (CO rebreathing) in endurance-trained untrained boys (n = 42, age 9.0-17.1 years, 61.6 ± 7.2 ml/kg/min, n 31, 8.0-17.7 46.5 6.1 respectively) girls 45, 8.2-17.0 51.4 5.7 36,...
We report that the change in cerebral blood velocity during a neurovascular coupling task (NVC) is similar pre- and postpubertal youth, regardless of exercise-training status. However, prepubertal untrained youth demonstrated greater increase pulsatility NVC when compared with their trained counterparts. Our findings highlight childhood represents unique opportunity for exercise-mediated adaptations cerebrovascular hemodynamics NVC, which may confer long-term benefits function.
Abstract Global cerebral blood flow (gCBF) and cerebrovascular reactivity to hypercapnia () are modulated by gonadal hormone activity, while insulin‐like growth factor 1 facilitates exercise‐mediated angiogenesis in adults. Whether critical periods of heightened hormonal neural development during puberty represent an opportunity further enhance gCBF is currently unknown. Therefore, we used duplex ultrasound assess n = 128 adolescents characterised as endurance‐exercise trained (males: 30,...
Intracranial blood velocity reactivity to a steady-state hypercapnic stimulus has been shown be similar in children and adults, but the onset response hypercapnia is slower child. Given vasodilatory effect of on cerebrovasculature, assessment vessel diameter, flow are vital fully elucidate whether temporal differs versus adults. Assessment internal carotid artery (ICA) diameter (ICAd), (ICAv), volumetric (QICA), shear rate (ICASR) 4 min challenge was completed (n = 14, 8 girls; 9.8 ± 0.7...
New Findings What is the central question of this study? Carotid artery peak circumferential strain (PCS) and rate attenuate with age, but appear to be modulated by cardiorespiratory fitness status in young males. However, relationship between habitual endurance exercise (running) these parameters has not been studied middle‐aged men. main finding its importance? Young runners exhibited elevated PCS systolic (S‐SR) compared non‐runners, running did influence diastolic (D‐SR). Habitual...
This study focused on the influence of habitual endurance exercise training (i.e., committed runner or nonrunner) regulation muscle sympathetic nerve activity (MSNA) and arterial pressure in middle-aged (50 to 63 yr, n = 23) younger (19 30 yr; normotensive men. Hemodynamic neurophysiological assessments were performed at rest. Indices vascular baroreflex function determined from relationship between spontaneous changes diastolic blood (DBP) MSNA. Large vessel stiffness left ventricular...
New Findings What is the central question of this study ? Common carotid artery (CCA) two‐dimensional strain imaging detects intrinsic arterial wall properties beyond conventional measures stiffness, but effect cardiorespiratory fitness on strain‐derived indices CCA stiffness unknown. main finding and its importance Two‐dimensional revealed greater peak circumferential systolic rate in highly fit men compared with their less counterparts. Altered mechanics might reflect training‐induced...
Changes in the arterial baroreflex arc contribute to elevated sympathetic outflow and altered reflex control of blood pressure with human aging. Using ultrasound microneurography (muscle nerve activity, MSNA) we investigated relationships between aortic carotid artery wall tension (indices baroreceptor activation) vascular operating point (OP; MSNA burst incidence) healthy, normotensive young (n = 27, 23 ± 3 yr) middle-aged men 22, 55 4 yr). In men, OP was positively related magnitude rate...
The extent of structural cardiac remodeling in response to endurance training is maturity dependent. In adults, this adaptation often associated with the left ventricular (LV) twist mechanics. For example, an increase LV follows expansion end-diastolic volume, whereas a reduction may follow thickening walls. While has been shown be more prominent post-peak height velocity (PHV), it remains determined how maturation-dependent influences twist. Therefore, we aimed (1) compare mechanics between...
Journal Article Blood-volume changes following operations Get access H F M Bassett, Bassett Consultant Cardio-Thoracic Surgeon The Royal Infirmary, Manchester Search for other works by this author on: Oxford Academic Google Scholar J S Talbot Research Assistant United Hospitals Grants Committee British of Surgery, Volume 55, Issue 8, August 1968, Pages 570–575, https://doi.org/10.1002/bjs.1800550803 Published: 06 December 2005
We report preliminary evidence of the “youth athlete’s artery,” characterized by training-related arterial remodeling and elevated endothelium-dependent function in children adolescents. However, adaptations brachial artery diameter flow-mediated dilation (FMD) were associated with cardiorespiratory fitness adolescents, but not children. Our findings indicate that is modifiable chronic exercise training during childhood, association between FMD only apparent later stages adolescence.
We determined the effect of habitual endurance exercise and age on aortic pulse wave velocity (aPWV), augmentation pressure (AP) systolic blood (aSBP), with statistical adjustments aPWV AP for heart rate mean arterial pressure, when appropriate. Furthermore, we assessed whether muscle sympathetic nerve activity (MSNA) correlates in young middle-aged men.Aortic PWV, AP, (applanation tonometry; SphygmoCor) MSNA (peroneal microneurography) were recorded 46 normotensive men who either or...
Cerebral blood velocity (CBv) in the anterior circulation was higher females compared with males irrespective of maturational stage, but not posterior circulation. In response to exercise, demonstrated a greater CBv males, especially post-peak height (post-PHV) where exercise more pronounced. Our findings suggest that both at rest and acute submaximal are altered by biological sex maturity-dependent manner.