A5067511817- Hemoglobinopathies and Related Disorders
- Erythrocyte Function and Pathophysiology
- Blood properties and coagulation
- Iron Metabolism and Disorders
- Blood groups and transfusion
- Cardiovascular and exercise physiology
- High Altitude and Hypoxia
- Erythropoietin and Anemia Treatment
- Sports Performance and Training
- Heart Rate Variability and Autonomic Control
- Bone and Joint Diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Exercise and Physiological Responses
- Thermoregulation and physiological responses
- Body Composition Measurement Techniques
- Acute Ischemic Stroke Management
- Sports injuries and prevention
- Neonatal Health and Biochemistry
- Cardiovascular Health and Disease Prevention
- Muscle metabolism and nutrition
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Hemoglobin structure and function
- Adipose Tissue and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
Université Claude Bernard Lyon 1
2016-2025
Laboratory of Excellence GR-Ex
2016-2025
Laboratoire Interuniversitaire de Biologie de la Motricité
2016-2025
Biologie Intégrée du Globule Rouge
2017-2025
Lyon College
2025
Institut Universitaire de France
2015-2024
Université Savoie Mont Blanc
2003-2024
Institut des Maladies Génétiques Imagine
2018-2024
Université Paris Cité
2012-2023
Hospices Civils de Lyon
2020-2021
This document, supported by both the International Society for Clinical Hemorheology and European Microcirculation, proposes new guidelines hemorheolog ...
Recent evidence suggests that red blood cell aggregation and the ratio of hematocrit to viscosity (HVR), an index oxygen transport potential blood, might considerably modulate flow dynamics in microcirculation. It thus seems likely these factors could play a role sickle disease.We compared characteristics, HVR at different shear rates between anemia hemoglobin C disease (SCC) patients, trait carriers (AS) control individuals (AA).Blood determined high rate was lower (n=21) than AA (n=52), AS...
Although pulmonary hypertension, leg ulcers, priapism, stroke and glomerulopathy in sickle cell anaemia (SCA) result from the adverse effects of chronic haemolysis on vascular function (haemolytic phenotype), osteonecrosis, acute chest syndrome painful vaso-occlusive crises are caused by abnormal adhesion increased blood viscosity (viscosity-vaso-occlusion phenotype). However, this model with two sub-phenotypes does not take into account haemorheological dimension. We tested relationships...
The aim of this study was to (1) analyze blood viscosity, red cell (RBC) deformability, and aggregation in hospitalized patients with Coronavirus disease 19 (COVID-19); (2) test the associations between impaired rheology coagulation; (3) several indicators clinical severity. A total 172 COVID-19, COVID-unit Internal Medicine Department (Lyon, France) participated January May 2021. Clinical parameters were collected for each patient. Routine hematological/biochemical parameters, RBC...
Here we describe the effects of a controlled, 30 min, high-intensity cycling test on blood rheology and metabolic profiles red cells (RBCs) plasma from well-trained males. RBCs demonstrated decreased deformability trended toward increased generation microparticles after test. Meanwhile, metabolomics lipidomics highlighted oxidative stress activation membrane lipid remodeling mechanisms in order to cope with altered properties circulation resulting physical exertion during Of note,...
Recent evidence suggests that autonomic nervous system activity could be involved in the pathophysiology of sickle cell disease, but it is unclear whether differences are detectable during steady state patients with mild and severe disease. The aim present study was to compare activity, blood rheology, inflammation anemia according frequency acute pain crisis.Twenty-four healthy volunteers, 20 milder 15 more disease were recruited. Milder defined as having no crisis within previous year....
Background Little is known about the effects of blood rheology on occurrence acute chest syndrome and painful vaso-occlusive crises in children with sickle cell anemia hemoglobin SC disease.Design Methods To address this issue, steady-state hemorheological profiles (blood viscosity, red deformability, aggregation properties) hematologic parameters were assessed 44 49 disease (8-16 years old) followed since birth. Clinical charts retrospectively reviewed to determine prior or episodes, rates...
Strenuous exercise is associated with an inflammatory response involving the activation of several types blood cells. In order to document specific these cell types, we studied effect three maximal tests conducted
Introduction An estimated 300 million people worldwide have sickle cell trait (SCT). Although largely benign, SCT has been associated with exertional rhabdomyolysis and exercise-related sudden death in warfighters/athletes (WA). The National Collegiate Athletic Association's policy to confirm a student athlete's status during their preparticipation medical examination prompted reaction from some organizations regarding the rationale ethical justification of policy. Methods On September 26...
Sickle cell anaemia (SS) and sickle cell-haemoglobin C disease (SC) patients exhibit severe red blood (RBC) rheological alterations involved in the development of several complications. The contribution oxidative stress these haemorheological abnormalities is still unknown. We compared RBC reactive oxygen species (ROS) glutathione (GSH) content, profile SS (n = 11), SC 11) healthy subjects 12) at baseline after in-vitro treatment with t-butyl hydroperoxide (TBHP). showed: (i) higher ROS...
Abstract Osmotic gradient ektacytometry is the gold standard to assess red blood cell (RBC) deformability. It has been proposed that, when measured in isotonic condition, RBC deformability at low shear stress would depend on membrane elasticity while it be influenced by internal viscosity high stress, but this hypothesis needs further addressed. Healthy RBCs were rigidified treatment with lysolecithine (LPC), diamide or nystatine associated hyperosmolar solutions (OSMO), which reduces...
Abnormal retention of mitochondria in mature red blood cells (RBC) has been recently reported sickle cell anemia (SCA) but their functionality and role the pathophysiology SCA remain unknown. The presence within RBC was determined by flow cytometry 61 patients ten healthy donors. Patients were classified according to percentage with contained whole population: low (0-4%), moderate (>4% <8%), or high level (>8%). rheological, hematological, senescence oxidative stress markers compared between...
We investigated the effect of time-of-day on both maximal sprint power and repeated-sprint ability (RSA). Nine volunteers (22+/-4 yrs) performed a RSA test in morning (07:00 to 09:00 h) evening (17:00 19:00 different days random order. The cycle consisted five, 6 sec sprints interspersed by 24 passive recovery. Both blood lactate concentration heart rate were higher than (lactate values post exercise: 13+/-3 versus 11+/-3 mmol/L(-1), p<0.05). peak developed during first was (958+/-112 vs....