A5005211890- Radical Photochemical Reactions
- Catalytic C–H Functionalization Methods
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Sulfur-Based Synthesis Techniques
- Chemical Synthesis and Analysis
- Reproductive System and Pregnancy
- Neuroscience and Neuropharmacology Research
- Retinoids in leukemia and cellular processes
- Antioxidant Activity and Oxidative Stress
- Immune Response and Inflammation
- Estrogen and related hormone effects
- GABA and Rice Research
- Free Radicals and Antioxidants
- Barrier Structure and Function Studies
- Gut microbiota and health
- Bipolar Disorder and Treatment
- Oxidative Organic Chemistry Reactions
- Bioactive Compounds and Antitumor Agents
- Biochemical Analysis and Sensing Techniques
- Biochemical effects in animals
Nanjing Normal University
2019-2021
Children's Hospital of Chongqing Medical University
2017-2018
Zunyi Medical University
2018
Chongqing Medical University
2014-2018
China International Science and Technology Cooperation
2017-2018
Hefei University of Technology
2013
An electrochemical four-component reaction cascade Mumm rearrangement was developed. It is a rare example of in situ generation O-acyl isoamides for 1,3-(O→N) acyl transfer. Inexpensive, commercially available arylethylenes, aryl or heterocyclic acids, acetonitrile, and alcohols were used as substrates. A wide range acids tolerated provided imides satisfactory yields. Subsequent hydrolysis could be utilized to synthesize valuable amides β-amino alcohol derivatives.
Vitamin A (VA) protects the intestinal epithelial barrier by improving cell migration and proliferation. Our previous studies demonstrated that VA deficiency (VAD) during pregnancy suppresses systemic mucosal immune responses in intestines of offspring supplementation (VAS) early life can increase counts. However, little is known about mechanisms which regulates function.Caco-2 cells were treated with all-trans retinoic acid (ATRA) for 24 hours to determine optimum ATRA concentration...
Abstract The electrochemical oxidative cross‐dehydrogenative coupling of arylsulfinic acids with thiophenols was achieved via a radical process. A wide range and substituted were found to be tolerated, providing unsymmetrical thiosulfonates in good excellent yields. This method can also used for the reaction disulfides or diselenides obtain selenosulfonates. magnified image
Electrochemical oxidative regioselective C–H cyanation of imidazo[1,2-a]pyridines was developed using readily available TMSCN as the cyano source. The KH2PO4/K2HPO4 buffer essential for this transformation. This protocol compatible with a broad range substituted and provided C3 cyanated products in moderate to excellent yields.
Inflammation drives the development of depression and may affect neurotransmitters thus neurocircuits increase risk depression. To investigate influence inhibition inflammatory pathways on biogenic amine metabolism in depressive rats, sertraline, meloxicam, inhibitors arachidonic acid - cyclooxygenase-2/lipoxygenase (AA-COX-2/5-LO) pathways, were given to rats. After model by chronic unpredictable mild stress (CUMS) for 6 weeks, Successful modeling rats selected randomly divided into CUMS...
Regioselective electrochemical oxidative C–H thiocyanation or selenocyanation of imidazopyridines was achieved by using an undivided electrolytic cell. Transition-metal- and oxidant-free conditions are striking features this protocol. A library thiocyanated with a broad range functional groups were synthesized in high yields. This method also applicable to the some electron-rich arenes.
Vitamin A is a critical micronutrient for regulating immunity in many organisms. Our previous study demonstrated that gestational or early-life vitamin deficiency decreases the number of immune cells offspring. The present aims to test whether supplementation can restore lymphocyte pools A-deficient rats and thereby improve function their intestinal mucosa; furthermore, aimed identify best time frame supplementation. pregnant offspring were administered low-dose daily 7 days starting on day...
The determination of amino acids with actions like neurotransmitters or modulators has been increasingly important for diagnosis in many neuropsychiatric diseases. A rapid and simple high-performance liquid chromatography fluorescence detection method was developed simultaneous seven acids: aspartate (Asp), glutamate (Glu), serine (Ser), glutamine (Gln), glycine (Gly), taurine (Tau) γ-aminobutyric` acid (GABA). Homoserine used as an internal standard. analysis performed on a BDS column...
In recent years, some studies have suggested that the activation of inflammatory system plays a role in occurrence depression. Tumor necrosis factor-α (TNF-α), as one preinflammatory cytokines, has been reported to be involved various diseases including Infliximab, an antagonist TNF-α, is usually used treat autoimmune such Crohn's disease and can perhaps other diseases. this study, antidepressant effect possible mechanism infliximab were investigated by studying depression-like behavior...
Abstract An electrochemical four‐component reaction cascade Mumm rearrangement was developed. It is a rare example of in situ generation O‐acyl isoamides for 1,3‐(O→N) acyl transfer. Inexpensive, commercially available arylethylenes, aryl or heterocyclic acids, acetonitrile, and alcohols were used as substrates. A wide range acids tolerated provided imides satisfactory yields. Subsequent hydrolysis could be utilized to synthesize valuable amides β‐amino alcohol derivatives.
Abstract The determination of amino acids and monoamine with actions like neurotransmitters or modulators has become increasingly important for studying the relationship between dysfunction pathogenesis diabetic encephalopathy. Here, a high‐performance liquid chromatography fluorescence detection method was developed to simultaneously determine nine monoamines including three excitatory (aspartate, glutamate, serotonin), four inhibitory (glycine, γ ‐aminobutyric acid, taurine, dopamine),...
Regioselective electrochemical oxidative C–H thiocyanation or selenocyanation of imidazopyridines was achieved by using an undivided electrolytic cell. Transition-metal- and oxidant-free conditions are striking features this protocol. A library thiocyanated with a broad range functional groups were synthesized in high yields. This method also applicable to the some electron-rich arenes.