A5101988567- Mesenchymal stem cell research
- MicroRNA in disease regulation
- Neurogenesis and neuroplasticity mechanisms
- Tissue Engineering and Regenerative Medicine
- Autism Spectrum Disorder Research
- Barrier Structure and Function Studies
- Cardiac Ischemia and Reperfusion
- Family and Disability Support Research
- Cancer-related molecular mechanisms research
- Child Nutrition and Feeding Issues
- RNA Interference and Gene Delivery
- Neonatal and fetal brain pathology
- Electrospun Nanofibers in Biomedical Applications
- Retinoids in leukemia and cellular processes
- Organ Transplantation Techniques and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Infant Development and Preterm Care
- Virus-based gene therapy research
- Sirtuins and Resveratrol in Medicine
- Cardiac Fibrosis and Remodeling
- Cancer-related Molecular Pathways
- Cancer Research and Treatments
- Polyomavirus and related diseases
- Metastasis and carcinoma case studies
- Gut microbiota and health
Chongqing Medical University
2011-2025
Children's Hospital of Chongqing Medical University
2011-2025
Guangdong Provincial People's Hospital
2021
Chongqing Maternal and Child Health Hospital
2020
China International Science and Technology Cooperation
2011-2020
University of South Florida
2011
Moffitt Cancer Center
2008
Molecular Oncology (United States)
2008
Veterans Health Administration
2008
University of Maryland, Baltimore
2008
Abstract Mesenchymal stem cell (MSC) transplantation reduces the neurological impairment caused by hypoxic-ischemic brain damage (HIBD) via immunomodulation. In current study, we found that MSC improved learning and memory function enhanced long-term potentiation in neonatal rats subjected to HIBD amount of IL-6 released from MSCs was far greater than other cytokines. However, neuroprotective effect infected with siIL-6-transduced recombinant lentivirus (siIL-6 MSCs) significantly weakened...
Background: MSCs are a promising therapeutic resource. Paracrine effects and the induction of differentiation patterns thought to represent two primary mechanisms underlying mesenchymal stem cell (MSC) transplantation in vivo. However, it is unclear which mechanism involved human umbilical cord-derived MSC (hUC-MSC) transplantation. Methods Results: Based on flow cytometry analysis, hUC-MSCs exhibited morphological characteristics surface markers MSCs. Following directed neural induction,...
Motor disturbance, as a related symptom of autism spectrum disorders (ASD), has not received the attention it deserves. We aimed to investigate different degrees motor developmental delay and influencing factors in Chinese preschool children with ASD, order enhance people's awareness ASD children. recruited 1,256 aged 2-6 years from China Multi-Center Preschool Autism Project (CMPAP). investigated overall status neurodevelopment through Revised Children Neuropsychological Behavior Scale...
The AP-1 transcription factor JunD is highly expressed in intestinal epithelial cells, but its exact role maintaining the integrity of barrier remains unknown. tight junction (TJ) protein zonula occludens (ZO)-1 links intracellular domain TJ-transmembrane proteins occludin, claudins, and junctional adhesion molecules to many cytoplasmic actin cytoskeleton crucial for assembly TJ complex. Here, we show that negatively regulates expression ZO-1 implicated regulation function. Increased levels...
Abstract Background Mesenchymal stem cells (MSCs) can be induced to differentiate into neuronal under appropriate cellular conditions and transplanted in brain injury neurodegenerative diseases animal models for neuroregeneration studies. In contrast the embryonic (ESCs), MSCs are easily subject aging senescence because of their finite ability self-renewal. seriously affected theirs application prospects as a promising tool cell-based regenerative medicine tissue engineering. present study,...
Our previous studies demonstrated that vitamin A deficiency (VAD) can impair the postnatal cognitive function of rats by damaging hippocampus. The present study examined effects retinoic acid (RA) on apoptosis induced hypoxic-ischemic damage in vivo and vitro, investigated possible signaling pathway involved neuroprotective anti-apoptotic RA. Flow cytometry, immunofluorescence staining behavioral tests were used to evaluate protein mRNA levels RARα, PI3K, Akt, Bad, caspase-3, caspase-8,...
BACKGROUND Mesenchymal stromal/stem cells (MSCs) are broadly used for many diseases, but the efficacy of MSC engraftment is very low due to viability and high cell death rate under a stressful microenvironment. The present study aimed investigate whether microRNA-34a (miR-34a), which downstream target P53, involved in H2O2-induced death. MATERIAL AND METHODS Human bone marrow MSCs (hMSCs) were purchased from Lonza cultured as previously described. hMSCs transfected with miR-34a inhibitor...
Background. Increasing evidence has revealed that mesenchymal stromal cell (MSC) transplantation alleviates hypoxic-ischemic brain damage (HIBD) induced neurological impairments via immunomodulating astrocyte antiapoptosis effects. However, it remains unclear whether MSCs regulate neuron autophagy following HIBD. Results. In the present study, MSC effectively ameliorated learning-memory function and suppressed stress-induced hippocampal in HIBD rats. Moreover, suppressive effects of on were...
Abstract DNA methylation is widely involved in the modification of intestinal function, but mechanism enteric nervous system has not been studied vitamin A deficiency (VAD). Herein, we firstly found that VAD group, gastrointestinal transit time was delayed compared with normal (VAN) group. RNA sequencing between and VAN rats identified enriched pathways associated nerves transferase complexes. Then expression levels methyltransferases (DNMT1, DNMT3a DNMT3b) were validated to significant...
Abstract Background Vitamin A deficiency (VAD) and sleep disturbances have been reported in children with autism spectrum disorder (ASD). The influence of vitamin (VA) levels on regulation ASD has garnered concern. present study aimed to characterize the association VA ASD. Methods This cross-sectional compared ( n = 856) typically developing (TDC; 316). We used Children’s Sleep Habits Questionnaire assess disturbances, Childhood Autism Rating Scale evaluate severity symptoms, Behavior...
The transplantation of human umbilical cord mesenchymal stem cells (hUC-MSCs) can promote hypoxic-ischemic brain damage (HIBD) nerve repair, but finding suitable seed to optimize and improve treatment efficiency is an urgent problem be solved. In this study, we induced hUC-MSCs into dedifferentiated (De-hUC-MSCs), the morphology, cell surface markers, proliferation tri-directional differentiation ability De-hUC-MSCs were detected. A whole-gene chip was utilized for genome cluster, gene...
Abstract Background: Genomic rearrangements involving EWSR1 and the CREB family of transcription factors are increasingly detected in an array mesenchymal neoplasms, including clear cell sarcoma-like tumors gastrointestinal tract (CCSLGT), a malignancy. Gastritis cystica profunda (GCP) is rare disease characterized by cystic dilatation gastric glands into submucosa generally regarded as precursor to tumor. Case presentation: Herein, we report peculiar case which EWSR1-CREM -rearranged tumor...