A5101971434- Retinoids in leukemia and cellular processes
- Child Nutrition and Water Access
- Birth, Development, and Health
- Antioxidant Activity and Oxidative Stress
- Vitamin C and Antioxidants Research
- Iron Metabolism and Disorders
- Obesity, Physical Activity, Diet
- Neuroscience and Neuropharmacology Research
- Pregnancy and preeclampsia studies
- Sperm and Testicular Function
- Mitochondrial Function and Pathology
- Folate and B Vitamins Research
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Mesenchymal stem cell research
- Neonatal and fetal brain pathology
- Nutritional Studies and Diet
- Reproductive System and Pregnancy
- Human Health and Disease
- Anesthesia and Neurotoxicity Research
- Receptor Mechanisms and Signaling
- Nuclear Receptors and Signaling
- Trace Elements in Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Neurogenesis and neuroplasticity mechanisms
Hunan University of Traditional Chinese Medicine
2024-2025
Shandong University
2003-2024
Baoding People's Hospital
2024
China Resources (China)
2023
Northwest A&F University
2023
Weifang Medical University
2023
Chongqing Medical University
2010-2020
Children's Hospital of Chongqing Medical University
2008-2020
China International Science and Technology Cooperation
2014-2020
Institute of Zoology
2003-2016
Vitamin A (VA) is important for postnatal brain development, and VA deficiency (VAD) can cause learning spatial memory deficits in rats. Most of the biological functions are mediated by retinoic acid (RA). To investigate mechanisms underlying deficits, mother rats were fed elemental diets to achieve blood levels classified as normal, deficient or severely deficient. Shuttle box Morris water maze tests revealed impairments ability memory, respectively, adolescent VAD (p 30-35)....
Abstract Our previous work identified NHA1, a testis-specific sodium–hydrogen exchanger, is specifically localized on the principal piece of mouse sperm flagellum. subsequent study suggested that number newborns and fertility rate NHA1-vaccinated female mice are significantly stepped down. In order to define physiological function NHA1 in spermatozoa, we generated Nha1 Fx/Fx , Zp3 -Cre (hereafter called cKO) found cKO males were viable subfertile with reduced motility. Notably, cyclic AMP...
Background Oxidative stress is linked to cognitive decline in the elderly. Diet, as a key energy source, affects brain function and serves modifiable risk factor for decline. Objective This study investigates relationship between Balance Score (OBS), which reflects diet lifestyle impact on oxidative stress, older adults. Methods utilized data from National Health Nutrition Examination Survey (NHANES) 2011–2014, including 2716 participants aged 60 older. Cognitive outcomes measured were...
To assess the impact of urbanisation on prevalence metabolic syndrome in Chinese adults.As part a community-based cross-sectional survey conducted 2002, sample from rural and urban populations East China was obtained. The is defined by National Cholesterol Education Program Adult Treatment Panel III criteria (ATP III) modified ATP III, which recommended lower waist circumference cut-off for Asians. Setting Field sites Jiangxi Anhui provinces Jing'an District Shanghai, China.A total 529...
The aim of our study was to examine the association vitamin A status with obesity and metabolic syndrome (MS) in school-age children Chongqing, China. cross-sectional conducted 1,928 aged 7~11 years from 5 schools Body height, weight, waist circumference (WC) blood pressure were measured. Blood glucose, lipids determined. Overall prevalences for overweight, MS 10.1%, 6.7% 3.5%, respectively. There 274 (14.2%) marginally deficient (MVAD) 53 (2.8%) (VAD) children, Serum obese group...
Mesenchymal stem cells (MSCs) can differentiate into neurons in an appropriate cellular environment. Retinoid signaling pathway is required neural development. However, the effect and mechanism through retinoid regulates neuronal differentiation of MSCs are still poorly understood. Here, we report that all‐trans‐retinoic acid (ATRA) pre‐induction improved rat MSCs. We found that, when were exposed to different concentrations ATRA (0.01–100 μmol/L) for 24 h then cultured with modified...
Abstract Background Mesenchymal stem cells (MSCs) can be induced to differentiate into neuronal under appropriate cellular conditions and transplanted in brain injury neurodegenerative diseases animal models for neuroregeneration studies. In contrast the embryonic (ESCs), MSCs are easily subject aging senescence because of their finite ability self-renewal. seriously affected theirs application prospects as a promising tool cell-based regenerative medicine tissue engineering. present study,...
Embryo implantation, endometrial stromal cell decidualization and formation of a functional placenta are critical processes in the establishment maintenance pregnancy. Interleukin (IL)-11 signalling is essential for adequate mouse uterus IL-11 promotes human. action mediated via binding to specific receptor alpha (IL-11Ralpha). The present study examined immunoreactive IL-11Ralpha cycling rhesus monkey endometrium, at implantation sites cynomolgus monkeys human first trimester decidua...
The objectives of the present work were to a new reference for age at childhood onset growth and investigate secular trend in timing puberty community‐based normal population Sweden. A total 2432 children with longitudinal length/height data from birth adulthood used determine two measures by visual inspection measured attained change velocity displayed on computer‐generated infancy‐childhood‐puberty (ICP) based chart. series represents sample full‐term born around 1974 Göteborg, We found...
Preschool children in developing countries are likely to have multiple, concurrent micronutrient deficiencies. This study was designed evaluate the effectiveness of different combinations nutritional fortified diet improve blood levels iron, vitamin A and other essential micronutrients preschool population Banan District Chongqing, China. From December 2005 June 2006, a total 226 2-6 y old were recruited from three nurseries area, they randomly assigned groups for 6 mo. Group I with A; II...
T helper 17 (Th17) cells play important roles in adaptive immunity and are involved several inflammatory autoimmune diseases, but little is known about their role tumour immunity. The current study investigated the involvement of Th17 multiple myeloma.Flow cytometry was used to investigate frequencies peripheral blood mononuclear from 30 patients with myeloma 14 healthy control subjects. concentrations Th17-associated cytokines (interleukin [IL]-6, IL-17, IL-1β IL-23) were measured by...
Our previous studies demonstrated that vitamin A deficiency (VAD) can impair the postnatal cognitive function of rats by damaging hippocampus. The present study examined effects retinoic acid (RA) on apoptosis induced hypoxic-ischemic damage in vivo and vitro, investigated possible signaling pathway involved neuroprotective anti-apoptotic RA. Flow cytometry, immunofluorescence staining behavioral tests were used to evaluate protein mRNA levels RARα, PI3K, Akt, Bad, caspase-3, caspase-8,...
Information about the effect of antioxidant vitamins nutrition during pregnancy on offsprings intellectual development is extremely limited.To investigate correlation (Vitamin A, E and C) at delivery neurodevelopment early childhood.A total 158 paired maternal-neonatal subjects were recruited. The serum concentrations vitamin C in maternal cord blood after determined was evaluated by Gesell Development Schedule (GDS) two years old.After adjusting for potential confounders, A placental...
Mild or marginal vitamin A deficiency (MVAD) is still a serious and widespread public health problem in pregnant women children developing countries. This study investigated rat lung maturation from prenatal to adult stage during pregnancy postnatal MVAD the recovery after supplementation (VAS). Adult female rats their offspring were randomized into three groups. 1. Control: mothers received normal diet.2. MVAD: The diet.3. VAS: diet till parturition, then diet. of VAS group given low-dose...
Background Non-communicable diseases are leading causes of disease burden in middle income countries. Little evidence exists to determine if the primary healthcare system can effectively manage non-communicable diseases. The purpose this study was examine effectiveness hypertension and diabetes management by system. Methods We used individual level data from 2009 National Basic Public Health Services System assess interventions on fasting plasma glucose, blood pressure. analyzed associations...
A difference in length or height growth is observed between populations developing and developed countries and, within a country, well-off poor subpopulations. The aim of this community-based study was to identify possible risk factors for stunting early life using the infancy-childhood-puberty (ICP) model. periurban slum, village an urban plus local control group Lahore, Pakistan, were investigated. In total, there 425 infants born from September 1984 March 1987 study. Children followed...