A5100356837- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Chemokine receptors and signaling
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Immune cells in cancer
- Circular RNAs in diseases
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Cytokine Signaling Pathways and Interactions
- Extracellular vesicles in disease
- Cancer-related gene regulation
- Immunotherapy and Immune Responses
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- Retinoids in leukemia and cellular processes
- NF-κB Signaling Pathways
- Estrogen and related hormone effects
Nanjing Medical University
2017-2025
BeiGene (China)
2019-2025
Henan University
2024-2025
Qilu University of Technology
2025
Shandong Academy of Sciences
2025
First Affiliated Hospital of Henan University
2025
Wannan Medical College
2025
Wuxi People's Hospital
2018-2025
Guiyang Medical University
2018-2025
Affiliated Hospital of Guizhou Medical University
2018-2025
Abstract Purpose: This study assessed the safety and efficacy of SHR-1210 (anti-PD-1 antibody) apatinib (VEGFR2 inhibitor) as combination therapy in patients with advanced hepatocellular carcinoma (HCC), gastric, or esophagogastric junction cancer (GC/EGJC). Patients Methods: was an open-label, dose-escalation (phase Ia) expansion Ib). In phase Ia, (n = 15) received 200 mg every 2 weeks 125–500 once daily until unacceptable toxicity disease progression. Ib, 28) at Ia–identified recommended...
Abstract Triple-negative breast cancers (TNBC) are aggressive with no effective targeted therapies. A combined database analysis identified 32 inflammation-related genes differentially expressed in TNBCs and 10 proved critical for anchorage-independent growth. In TNBC cells, an LPA-LPAR2-EZH2 NF-κB signaling cascade was essential expression of interleukin (IL)-6, IL-8, CXCL1. Concurrent inhibition IL-6 IL-8 dramatically inhibited colony formation cell survival vitro stanched tumor...
Transition nuclear proteins (TPs), the major found in chromatin of condensing spermatids, are believed to be important for histone displacement and condensation during mammalian spermatogenesis. We generated mice lacking TP, TP1, by targeted deletion Tnp1 gene mouse embryonic stem cells. Surprisingly, testis weights sperm production were normal mutant mice, only subtle abnormalities observed morphology. Electron microscopy revealed large rod-like structures step 13 contrast fine fibrils wild...
TGFB2-OT1 (TGFB2 overlapping transcript 1) is a newly discovered long noncoding RNA (lncRNA) derived from the 3'UTR of TGFB2. It can regulate autophagy in vascular endothelial cells (VECs). However, mechanisms action are unclear, and whether it involved VECs dysfunction needs investigation. Here, level was markedly increased by lipopolysaccharide oxidized low-density lipoprotein, 2 inflammation triggers. A chemical small molecule, 3-benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2(3H)-one...
Significance Immunotherapy, especially blockade of the PD-1/PD-L1 and CTLA-4 axes, has resulted in durable responses a range cancers. However, remain heterogeneous among patients. Treatment outcome results from changes tumor microenvironment imposed by such blockade. Here, we use immuno-PET single-cell RNA sequencing to increase our understanding dynamics immune cells their functional status response PD-1 Our data provide insights into CD8 + T myeloid compartment
Epithelial cells line the intestinal mucosa and form an important barrier to a wide array of noxious substances in lumen. Disruption integrity occurs commonly various pathologies. Long noncoding RNAs (lncRNAs) control diverse biological processes, but little is known about role lncRNAs regulation gut permeability. Here we show that lncRNA SPRY4-IT1 regulates epithelial function by altering expression tight junction (TJ) proteins. silencing led dysfunction cultured decreasing stability mRNAs...
Single-cell genomics is rapidly advancing our knowledge of the diversity cell phenotypes, including both types and states. Driven by single-cell/-nucleus RNA sequencing (scRNA-seq), comprehensive atlas projects characterizing a wide range organisms tissues are currently underway. As result, it critical that transcriptional phenotypes discovered defined disseminated in consistent concise manner. Molecular biomarkers have historically played an important role biological research, from defining...
Down syndrome (DS), or trisomy 21, is one of the critical risk factors for early-onset Alzheimer's disease (AD), implicating key roles chromosome 21-encoded genes in pathogenesis AD. We previously identified a role deubiquitinase USP25, encoded on regulating microglial homeostasis AD brain; however, whether USP25 affects amyloid pathology remains unknown. Here, by crossing 5×FAD and Dp16 DS mice, we observed that 21 exacerbated brain. Moreover, bacterial artificial (BAC) transgene-mediated...
Abstract Colorectal cancer (CRC) is a usual and kind of lethiferous cancer. Cuproptosis-related gene ferredoxin 1 (FDX1) has been discovered to act as suppressor, thereby suppressing some cancers’ progression. But, the regulatory functions FDX1 in CRC progression keep vague. In this work, at first, through TCGA database, it was revealed that exhibited lower expression COAD (colon adenocarcinoma) tissues, patients with had worse prognosis. Furthermore, verified be down-regulated tissues ( n =...
Because of the potential role histone ubiquitination in altering chromatin structure, we characterized levels specific histones meiotic and postmeiotic germ cells rat testes by two-dimensional gel electrophoresis. The major ubiquitinated forms, mono- poly-ubiquitinated H2A, were highest pachytene spermatocyte stage, declined thereafter through round spermatid reached their lowest elongating spermatids. Three additional species, besides detected using anti-ubiquitin antibodies specifically...
// Xiao-ming Meng 1,2 , Yun Zhang 1,3 Xiao-Ru Huang 1 Gui-ling Ren 2 Jun Li and Hui Yao Lan Department of Medicine Therapeutics, Ka Shing Institute Health Sciences, Shenzhen Research Institute, The Chinese University Hong Kong, Kong SAR School Pharmacy, Anhui Medical University, An Hui, China 3 Dermatology, Foshan Hospital TCM, Foshan, Correspondence to: Lan, email: Keywords : treatment for fibrosis, TGF-β/Smads, asiatic acid, naringenin, Pathology section Received July 08, 2015...
Cancer stem-like cells (CSC) are thought to drive tumor initiation, metastasis, relapse, and therapeutic resistance, but their specific pathogenic characters in many cancers, including non-small cell lung cancer (NSCLC), have yet be well defined. Here, we develop findings that the growth factor HGF promotes CSC sphere formation NSCLC populations. In patient-derived sphere-forming assays (PD-SFA) with HGF, CD49f CD104 were defined as novel markers of (LCSC). particular, isolated a...
Biological markers that can be used to predict the risk of intracranial aneurysms (IAs) are not available.To clarify whether circulating microRNAs could as biomarkers for IA, we carried out microarray assays in a screening cohort 40 IA patients (20 unruptured and 20 ruptured) healthy volunteers. We identified were unanimously changed both ruptured patients. confirmed 60% these by separate test with an independent validation (n=143 including 93 patients). To identify potential biomarkers,...
Recent evidence indicates that cancer cells, even in the absence of a primary tumor, recirculate from established secondary lesions to further seed and colonize skeleton soft tissues, thus expanding metastatic dissemination precipitating clinical progression terminal disease. Recently, we reported breast cells utilize chemokine receptor CX3CR1 exit blood circulation lodge experimental animals. Now, show is overexpressed human tumors skeletal metastases. To assess potential targeting cancer,...
Abstract RNA methylation can reverse the modification at level, which is an extremely important epigenetic modification. The function and mechanism of YTHDF2, as a reader m6A modification, in epithelial ovarian cancer (EOC) have not been elucidated so far. This study aimed to investigate how YTHDF2 miR-145 modulated EOC progression through It demonstrated that was significantly upregulated tissues compared with normal tissues. Further functional studies confirmed promoted proliferation...