A5025945798- Wound Healing and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Burn Injury Management and Outcomes
- Single-cell and spatial transcriptomics
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Mesenchymal stem cell research
- Neuroendocrine Tumor Research Advances
- Cancer Cells and Metastasis
- Surgical Sutures and Adhesives
- Orthopedic Surgery and Rehabilitation
- Tracheal and airway disorders
- Breast Implant and Reconstruction
- Reconstructive Facial Surgery Techniques
- Urinary Bladder and Prostate Research
- Urological Disorders and Treatments
- Surgical site infection prevention
- COVID-19 and healthcare impacts
- Prostate Cancer Diagnosis and Treatment
- Algebraic Geometry and Number Theory
- Diabetic Foot Ulcer Assessment and Management
- Bone fractures and treatments
- Angiogenesis and VEGF in Cancer
- Urologic and reproductive health conditions
Weizmann Institute of Science
2020-2025
Georg Speyer Haus
2025
Medical University of South Carolina
2018-2022
Stoke Mandeville Hospital
2010-2021
Buckinghamshire Healthcare NHS Trust
2012-2021
University of Exeter
2021
Saint John's Health Center
2018
SUNY Downstate Health Sciences University
2017
Kings County Hospital Center
2017
New York Proton Center
2015
Background: The association between scarring and the depth of dermal injury or burn is clinically recognized but not quantified. authors tested hypothesis that there a critical beyond which fibrous scar develops. Methods: A novel jig produced wound was deep at one end superficial other. Pilot studies in cadaveric ex vivo breast skin confirmed injury. Healthy volunteers had standardized made on lateral aspect hip. Digital photography recorded surface appearance healing development....
Abstract Epithelial-to-mesenchymal transition (EMT) is the most commonly cited mechanism for cancer metastasis, but it difficult to distinguish from profiles of normal stromal cells in tumour microenvironment. In this study we use published single cell RNA-seq data directly compare mesenchymal signatures and cells. Informed by these comparisons, developed a computational framework decouple two sources expression using bulk datasets. This deconvolution offers opportunity characterise EMT...
Bone marrow-derived endothelial progenitor cells (EPCs) have been detected in the peripheral blood of patients following thermal injury. EPCs migrate to sites active neovascularization response mediators released after trauma, contributing wound healing. The aim was characterize levels and kinetics burned patients, then relate these key mobilizing factors, vascular growth factor (VEGF) chemokine (C-X-C motif) ligand 12 (CXCL 12), compare them with those healthy subjects.The study included 19...
We measured grip and pinch strengths in non-manual, light manual heavy workers using a Jamar dynamometer measuring device. Heavy had the strongest grips with least difference between sides. Office weakest greatest Light were these two groups. Consequently, occupation of patient must be taken into account when strength measurements to assess need for rehabilitation medicolegal reports.
In order to assess the influence of vertebral heart scale (VHS) on accuracy radiographic diagnosis cardiac disease, thoracic radiographs 50 dogs with proven 26 other diseases, and no clinical signs cardiovascular or respiratory disease were mixed examined by three independent, blinded observers chosen represent a range abilities. They first all without making measurements VHS made diagnosis. then re‐examined radiographs, measured both lateral dorsoventral ventrodorsal before again recording...
Abstract Background Burn injuries are a major cause of morbidity and mortality worldwide. Cooling is widely practised as first aid measure, but the efficacy cooling burns in human skin has not been demonstrated. A safe, consistent, ethically acceptable model burning live vivo was developed, used to quantify effects cooling. Methods Novel apparatus manufactured create cool women who were anaesthetized for breast reconstruction surgery using deep inferior epigastric artery perforator flap....
Abstract Each tumor contains malignant cells that differ in genotype, phenotype, and their interactions with the micro-environment (TME). This results distinct integrated cellular states govern intra-tumor heterogeneity (ITH), a central challenge of cancer therapeutics. Dozens recent studies have begun to describe ITH by single cell RNA-seq, but each study typically profiledonly small number tumors provided narrow view transcriptional ITH. Here, we curate, annotate integrate data from 77...
Revascularization of the damaged tissue is pivotal to repair. Here, by bringing together two in vitro model systems, we have been able examine (1) ability human umbilical vein endothelial cells (HUVEC) containing a complete hierarchy progenitors derived from cord generate vascular tubules within stromal niche and (2) effects exposure low oxygen tensions on progenitor cell proliferation tubule formation vitro. Our results demonstrate that high proliferative potential colony forming (HPP-ECFC)...
Approximately 45,000 women are diagnosed with breast cancer in the UK each year. The success of screening and introduction adjuvant therapies have meant that prognosis is improving an increasing number patients seeking reconstruction following mastectomy. purpose this study was to evaluate deep inferior epigastric perforator (DIEP) flap reconstructions performed Stoke Mandeville Hospital and, through analysis complications, detail evolution current care pathway.A retrospective all DIEP by...
Abstract Single-cell RNA-seq (scRNA-seq) has transformed the study of cancer biology. Recent years have seen a rapid expansion in number single-cell studies, yet most these studies profiled few tumours, such that individual datasets limited statistical power. Combining data and results across holds great promise but also involves various challenges. We recently began to address challenges by curating large collection scRNA-seq datasets, leveraging it for systematic analyses tumor...
A 23 year old male kick boxer presented with a 24 hour history of pain and being unable to extend the interphalangeal joint left thumb. There was no trauma or any other risk factor for spontaneous rupture extensor pollicis longus tendon. On previous day, he had been doing reverse press ups on dorsum his hands wrists hyperflexed as part training boxing. At operation tendon found be divided at level dorsal tubercle radius not directly repairable. The treatment an indicis proprius transfer. We...
To compare the surgical outcomes of men with bladder outlet obstruction (BOO) due to benign prostatic (BPO) those detrusor underactivity (DU) or acontractile (DA).This retrospective, IRB approved study included who underwent BPO surgery for refractory LUTS urinary retention. Patients were grouped based on videourodynamic (VUDS) findings: 1) BOO, 2) DU and 3) DA. The primary outcome measure was Patient Global Impression Improvement (PGII). Secondary measures uroflow (Qmax), post-void residual...
Abstract A study was carried out to determine the incidence of increased serum amylase activity in patients with ruptured aortic aneurysm during 48 h after presentation and assess its clinical significance. In a prospective series 25 patients, hyperamylasaemia occurred ten significantly associated poor outcome (P=0·005). who died or had major complication, higher than those an uncomplicated postoperative recovery (P<0·05). There correlation between preoperative length stay intensive...
Abstract Background The Department of Health in the UK has developed new consent guidance but without clear recommendations on how incidence and severity a given risk should influence its discussion during process obtaining informed consent. Plastic surgery is litigation-prone specialty that offers paradigm for assessing attitudes to Methods A questionnaire was sent all surgeons at six plastic reconstructive units within UK. It enquired what relatively frequent minor such as wound infection,...