A5100379350- Retinoids in leukemia and cellular processes
- Acute Myeloid Leukemia Research
- Advanced biosensing and bioanalysis techniques
- Cancer, Lipids, and Metabolism
- Antioxidant Activity and Oxidative Stress
- Protein Degradation and Inhibitors
- Acute Lymphoblastic Leukemia research
- Single-cell and spatial transcriptomics
- Muscle Physiology and Disorders
- Arsenic contamination and mitigation
- Chronic Myeloid Leukemia Treatments
- Pluripotent Stem Cells Research
- Nutrition and Health in Aging
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- Molecular Biology Techniques and Applications
- Drug-Induced Ocular Toxicity
- Frailty in Older Adults
- GDF15 and Related Biomarkers
- Vascular Tumors and Angiosarcomas
- Pregnancy and Medication Impact
- Temporomandibular Joint Disorders
- Neurogenesis and neuroplasticity mechanisms
- Histone Deacetylase Inhibitors Research
- Moyamoya disease diagnosis and treatment
Shanghai Jiao Tong University
2015-2025
Shanghai Sixth People's Hospital
2009-2025
Ruijin Hospital
2017-2024
Shanghai Institute of Hematology
2008-2024
Second Affiliated Hospital of Xi'an Jiaotong University
2024
Fuzhou Second Hospital
2024
Shanghai Ninth People's Hospital
2023
Second Military Medical University
2013-2014
Changhai Hospital
2013-2014
Renji Hospital
2014
Significance The APL2012 trial is currently the largest randomized, multicenter clinical study of APL based on ATRA-ATO treatment with risk stratification. We enrolled 855 newly diagnosed patients during December 2012 to 2017 for careful follow-up. All received ATRA-ATO–based protocols remission induction. At consolidation phase, key part trial, ATO was used replace or reduce chemotherapy in a risk-stratified way. Patients were then treated as maintenance. results indicated not only...
Vitamin A (VA) is important for postnatal brain development, and VA deficiency (VAD) can cause learning spatial memory deficits in rats. Most of the biological functions are mediated by retinoic acid (RA). To investigate mechanisms underlying deficits, mother rats were fed elemental diets to achieve blood levels classified as normal, deficient or severely deficient. Shuttle box Morris water maze tests revealed impairments ability memory, respectively, adolescent VAD (p 30-35)....
Acute promyelocytic leukemia (APL) is a model for synergistic target cancer therapy using all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), which yields very high 5-year overall survival (OS) rate of 85 to 90%. Nevertheless, about 15% APL patients still get early death or relapse. We performed this study address the possible impact additional gene mutations on outcome APL.We included consecutive series 266 cases as training group, then validated results in testing group 269...
Skeletal muscle wasting is a feature of cancer cachexia that increases patient morbidity and mortality. Matrine, the main bioactive component Sophora flavescens, has been approved for prevention therapy in China. However, to best our knowledge, its mechanism improving remains unknown. The present study demonstrated matrine fiber size mass an vivo CT26 colon adenocarcinoma mouse model. Concurrently, other symptoms, including body organ weight loss, were alleviated. In vitro experiments,...
The purpose of this study was to evaluate the effect reverse pull headgear (RPHG) in treatment Class III malocclusions late mixed and early permanent dentition its long-term stability at time when facial growth close completion. group comprised 22 subjects (12 males 10 females, mean age: 11.38 ± 0.69 years). control included 17 (7 11.54 1.07 RPHG 1.5 0.95 years observation for 1.75 0.83 years. For each subject, lateral cephalograms were obtained before (T1) after (T2) or observation. These...
Genetic alternations can occur at noncoding regions, but how they contribute to cancer pathogenesis is poorly understood. Here, we established a mutational landscape of cis-regulatory regions (CREs) in acute promyelocytic leukemia (APL) based on whole-genome sequencing analysis paired tumor and germline samples from 24 patients epigenetic profiling 16 patients. Mutations occurring CREs preferentially active enhancers bound by the complex master transcription factors APL. Among significantly...
Abstract Purpose: The current stratification system for acute promyelocytic leukemia (APL) is based on the white blood cell (WBC) and platelet counts (i.e., Sanz score) over past two decades. However, borderlines among different risk groups are sometimes ambiguous, some patients, early death relapse remained challenges. Besides, with evolving of treatment strategy from all-trans-retinoic acid (ATRA) chemotherapy to ATRA–arsenic trioxide-based synergistic targeted therapy, precise molecular...
Abstract Acute promyelocytic leukemia (APL) represents a paradigm for targeted differentiation therapy, with minority of patients experiencing treatment failure and even early death. We here report comprehensive single-cell analysis 16 APL patients, uncovering cellular compositions their impact on all-trans retinoic acid (ATRA) response in vivo unveil hierarchy within blasts, rooted leukemic stem-like cells. The oncogenic PML/RARα fusion protein exerts branch-specific regulation the...
Abstract The second polar body (PB2) transfer in assisted reproductive technology is regarded as the most promising mitochondrial replacement scheme for preventing disease inheritance owing to its less carryover and stronger operability. However, was still detectable reconstructed oocyte conventional scheme. Moreover, delayed operating time would increase DNA damage. In this study, we established a spindle‐protrusion‐retained separation technique, which allowed us perform earlier avoid...
Patients with newly diagnosed acute promyelocytic leukemia (APL) are often obese or overweight, accompanied by metabolic disorders, such as dyslipidemia. However, the link between dyslipidemia and is obscure. Here, we conducted a retrospective study containing 1,412 cases (319 APL patients, 393 non-APL myeloid 700 non-tumor controls) found that patients had higher triglyceride levels than non- control groups. Using clinical data, revealed hypertriglyceridemia served risk factor for early...
Abstract Mantle cell lymphoma (MCL) is a rare and aggressive type of B-cell non-Hodgkin's lymphoma. Patients become progressively refractory to conventional chemotherapy, their prognosis poor. However, 38% remission rate has been recently reported in MCL treated with temsirolimus, mTOR inhibitor. Here we had the opportunity study case who tumor regression two months after temsirolimus treatment, progression-free survival 10 months. In this case, lymph node biopsies were performed before six...
Background: Although clinical vitamin A deficiency (VAD), which is a public health problem developing throughout the world, has been well controlled, marginal (MVAD) far more prevalent, especially among pregnant women and preschool children in China. Increasing evidence suggests that VAD involved pathogenesis of Alzheimer's disease (AD). However, whether MVAD, beginning early life, increases risk AD yet to be determined. Keywords: disease, amyloid β , A, deficiency, memory deficits, retinoic...
Abstract Objectives For patients with acute promyelocytic leukaemia ( APL ), negative reading of a leukaemia/retinoic acid receptor‐alpha PML ‐ RAR α ) transcript after induction therapy correlates good prognosis. However, in the majority given all‐ trans retinoic ATRA )/anthracycline‐based therapy, remains even when haematologic complete remission is achieved. To facilitate maximal therapeutic efficacy for , this study tested whether addition arsenic trioxide ATO would increase rate...
Abstract Hepatic sinusoidal obstruction disease (HSOS) is a rare but life-threatening vascular liver disease. However, its underlying mechanism and molecular changes in HSOS are largely unknown, thus greatly hindering the development of effective treatment. endothelial cells (HSECs) primary essential target for HSOS. A tandem mass tag-based shotgun proteomics study was performed using cultured HSECs from mice with induced by senecionine, representative toxic pyrrolizidine alkaloid (PA)....
The arsenic trioxide (ATO) plus all-trans retinoic acid (ATRA) therapy has demonstrated a tremendous success in the first-line treatment of acute promyelocytic leukemia (APL). Actually, early death (ED) is currently thought as major challenge APL. ATO been reported to inhibit platelet function vitro, and whether it increases ED rate by exacerbating hemorrhagic symptoms remains be investigated.Effects on aggregation adhesion were evaluated vitro thirty-two complete remission (CR) four newly...
This study aimed to identify differentially expressed genes (DEGs) of unruptured intracranial aneurysms (IAs) and provide beneficial information for early diagnosis treatment IAs. The gene expression profile GSE26969 from the Gene Expression Omnibus database was downloaded, which included six human IA samples: three arterial aneurysm samples normal superficial temporal artery (control). Based on these data, we identified DEGs between disease with packages in R language. selected were further...
Abstract Background Arsenic trioxide [ATO, inorganic arsenite (iAs III ) in solution] plays an important role the treatment of acute promyelocytic leukemia (APL). However, long-term adverse effects (AEs) and retention arsenic among APL patients are rarely reported. In this study, we focused on methylation metabolism its relationship with chronic hepatic toxicity, as previously reported, who had finished ATO. Methods A total 112 de novo completed ATO-containing were enrolled study. species...