A5090495842- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Retinoids in leukemia and cellular processes
- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Eosinophilic Disorders and Syndromes
- Multiple Myeloma Research and Treatments
- Cancer Treatment and Pharmacology
- Platelet Disorders and Treatments
- Neutropenia and Cancer Infections
- Viral-associated cancers and disorders
- Antioxidant Activity and Oxidative Stress
- Protein Degradation and Inhibitors
- Advanced Graph Neural Networks
- Histone Deacetylase Inhibitors Research
- Hematological disorders and diagnostics
- Antifungal resistance and susceptibility
- Peptidase Inhibition and Analysis
- Lung Cancer Treatments and Mutations
- Drug-Induced Ocular Toxicity
- Immune Cell Function and Interaction
- Fungal Infections and Studies
- Cell death mechanisms and regulation
- Vascular Tumors and Angiosarcomas
University of Electronic Science and Technology of China
2023-2025
Shanghai Institute of Hematology
2010-2024
Wannan Medical College
2024
Ruijin Hospital
2013-2023
Shanghai Jiao Tong University
2010-2022
Fujian Provincial Cancer Hospital
2020
Nanjing University
2018
Jiangsu Provincial Hospital of Traditional Chinese Medicine
2017
Qilu Hospital of Shandong University
2015
Shanghai Third People's Hospital
2013
Treatment with dasatinib, a highly potent BCR-ABL kinase inhibitor, has resulted in high rates of complete cytogenetic response and progression-free survival among patients chronic myeloid leukemia (CML) the phase, after failure imatinib treatment. We assessed efficacy safety as compared imatinib, for first-line treatment chronic-phase CML.In multinational study, 519 newly diagnosed CML were randomly assigned to receive dasatinib at dose 100 mg once daily (259 patients) or 400 (260...
Both all-trans retinoic acid (ATRA) and arsenic trioxide (As(2)O(3)) have proven to be very effective in obtaining high clinical complete remission (CR) rates acute promyelocytic leukemia (APL), but they had not been used jointly an integrated treatment protocol for induction or maintenance among newly diagnosed APL patients. In this study, 61 subjects were randomized into three groups, namely by ATRA, As(2)O(3), the combination of two drugs. CR was determined hematological analysis, tumor...
Genomic landscapes of 92 adult and 111 pediatric patients with B-cell acute lymphoblastic leukemia (B-ALL) were investigated using next-generation sequencing copy number alteration analysis. Recurrent gene mutations fusions tested in an additional 87 93 patients. Among the 29 newly identified in-frame fusions, those involving MEF2D ZNF384 clinically relevant demonstrated to perturb differentiation, EP300-ZNF384 inducing mice. Eight expression subgroups associated characteristic genetic...
To explore the genetic abnormalities that cooperate with AML1-ETO ( AE ) fusion gene to cause acute myeloid leukemia (AML) t(8;21), we screened a number of candidate genes and identified 11 types mutations in C-KIT mC-KIT ), including 6 previously undescribed ones among 26 54 (48.1%) cases t(8;21). address possible chronological order between mC-KIT, showed that, patients , most leukemic cells at disease presentation harbored both alteration, whereas three such investigated during complete...
Unsupervised heterogeneous graph representation learning (UHGRL) has gained increasing attention due to its significance in handling practical graphs without labels. However, heterophily been largely ignored, despite ubiquitous presence real-world graphs. In this article, we define semantic and propose an innovative framework called latent guided unsupervised (LatGRL) handle problem. First, develop a similarity mining method that couples global structures attributes, enabling the...
Abstract Purpose: NOTCH signaling pathway is essential in T-cell development and NOTCH1 mutations are frequently present acute lymphoblastic leukemia (T-ALL). To gain insight into its clinical significance, mutation was investigated 77 patients with T-ALL. Experimental Design: Detection of done using reverse transcription-PCR amplification direct sequencing, thereby compared according to the clinical/biological data patients. Results: Thirty-two were identified 29 (with dual 3 cases),...
Highlights•Incidence of invasive fungal disease was 7.7% overall; 9.0% allogeneic hematopoietic stem cell transplantation and 4.3% autologous transplantation.•Cumulative incidence increased steeply the first month after transplantation.•Antifungal prophylaxis independently protective against disease.•Therapeutic antifungal rate 40.6% (36.7% treated in hospital, whom 82.3% received empirical treatment).•Invasive substantially mortality.AbstractThe China Assessment Antifungal Therapy...
Tourist marketers rely heavily on using visual stimuli in their advertising to attract attention and improve awareness interest of experience. This study used eye-tracking self-reported recall methods investigate online tourism advertisement effectiveness based the hierarchy effects model. A within-subjects experimental design ( n = 30) was examine mock advertisements (stimuli) containing various combinations image, text product price. Results show that both image price least effective,...
Acute promyelocytic leukemia (APL) is a model for synergistic target cancer therapy using all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), which yields very high 5-year overall survival (OS) rate of 85 to 90%. Nevertheless, about 15% APL patients still get early death or relapse. We performed this study address the possible impact additional gene mutations on outcome APL.We included consecutive series 266 cases as training group, then validated results in testing group 269...
Antide is the decapeptide N-Ac-D-Nal(2),D-Phe(pCl),D-Pal(3),Ser,Lys(Nic),D-Lys(Nic),Leu,Lys(iPr),P ro,D- Ala-NH2 [Nal(2) represents 3-(2-naphthyl)alanine; Phe(p-Cl) 3-(4-chlorophenyl)alanine; Pal(3) 3-(3-pyridyl)alanine; Lys(Nic) N epsilon-nicotinoyllysine; Lys-(iPr) epsilon-isopropyllysine], which an antagonist of luteinizing hormone-releasing hormone (LHRH), has high antiovulatory activity, releases negligible histamine, and scheduled for scale-up, safety testing, evaluation in...
Recent advances in CV and NLP have inspired researchers to develop general-purpose graph foundation models through pre-training across diverse domains. However, a fundamental challenge arises from the substantial differences topologies Additionally, real-world graphs are often sparse prone noisy connections adversarial attacks. To address these issues, we propose Multi-Domain Graph Foundation Model (MDGFM), unified framework that aligns leverages cross-domain topological information...
Nilotinib has shown favorable safety in patients with Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) (CML-CP) or accelerated phase (CML-AP) who failed prior imatinib, and superior efficacy over imatinib newly diagnosed Ph+ CML-CP. Reported here are the data for CML-AP (n = 181) blast crisis (CML-BC) 190; BC, 133; lymphoid 50; unknown, seven) enrolled an expanded access IIIb study. Non-hematologic adverse events were mostly mild to moderate. Drug-related...
// Yang Wang 1, 2, * , Ning Shao Xueying Mao 3, Minmin Zhu Weifei Fan 4, Zhixiang Shen Rong Xiao 5, Chuncai 5 Wenping Bao Xinyu Xu 1 Chun Jian Dong Deshui Yu Yan Wu Caixia Liting Wen Xiaojie Lu 6, # Yong-Jie Ninghan Feng Department of Urology, Affiliated Wuxi No. 2 Hospital Nanjing Medical University, Wuxi, China School, Jiangnan 3 Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University London, United Kingdom 4 Jiangsu Province Geriatric Nanjing, College Clinical...