A5101839321- Viral-associated cancers and disorders
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Histiocytic Disorders and Treatments
- Cancer therapeutics and mechanisms
- Glycosylation and Glycoproteins Research
- Gastric Cancer Management and Outcomes
- interferon and immune responses
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Lymphoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Herpesvirus Infections and Treatments
- Circular RNAs in diseases
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Research Studies
- Extracellular vesicles in disease
- Cytomegalovirus and herpesvirus research
- Lung Cancer Diagnosis and Treatment
Jiangsu Province Hospital
2011-2017
Abstract Background Kaposi's sarcoma-associated herpesvirus (KSHV) is causally linked to several acquired immunodeficiency syndrome-related malignancies, including sarcoma (KS), primary effusion lymphoma (PEL) and a subset of multicentric Castleman's disease. Regulation viral lytic replication critical the initiation progression KS. Recently, we reported that herpes simplex virus type 1 (HSV-1) was an important cofactor activated cycle KSHV. Here, further investigated possible signal...
// Yang Wang 1, 2, * , Ning Shao Xueying Mao 3, Minmin Zhu Weifei Fan 4, Zhixiang Shen Rong Xiao 5, Chuncai 5 Wenping Bao Xinyu Xu 1 Chun Jian Dong Deshui Yu Yan Wu Caixia Liting Wen Xiaojie Lu 6, # Yong-Jie Ninghan Feng Department of Urology, Affiliated Wuxi No. 2 Hospital Nanjing Medical University, Wuxi, China School, Jiangnan 3 Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University London, United Kingdom 4 Jiangsu Province Geriatric Nanjing, College Clinical...
Pemetrexed (PEM), a multi-targeted antifolate, has promising clinical activity in non-squamous non-small cell lung cancer. However, the majority of patients eventually acquire resistance to PEM. To evaluate resistant mechanisms, A549 adenocarcinoma line was exposed stepwise increasing PEM concentrations 1.6, 6.4 and 16 μM establish three PEM-resistant cancer lines, A549/PEM-1.6, -6.4 -16. Growth inhibition determined by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay....
The human oncogenic virus Kaposi's sarcoma-associated herpesvirus (KSHV) is linked to sarcoma (KS), a tumor of endothelial cells characterized by angiogenesis and invasiveness. KSHV genome encodes 25 mature microRNAs (miRNAs), but their roles in KSHV-induced dissemination are not fully understood. In this study, we constructed the sensor reporters miRNAs used luciferase reporter assay demonstrate function mimics miRNAs. Then, examined expression matrix metalloproteinases (MMPs)...
Pemetrexed continuation maintenance therapy has been proven to be beneficial for patients with advanced non-squamous non-small cell lung cancer (NSCLC). However, the eligibility criteria treatment are too simple. This study sought evaluate thymidylate synthase (TS) as a predicting biomarker pemetrexed in NSCLC. Specimens were collected from 87 treated before and after four-cycle induction chemotherapy. Real-time quantitative PCR was used detect TS expression tissues. The level correlated...
Background: To evaluate the clinical efficacy and toxicity of single pemetrexed treatment compared with platinum-based doublet pemetrexed-based as first-line for advanced nonsquamous nonsmall cell lung cancer (NS-NSCLC) in elderly Chinese patients. Methods: The study retrospectively reviewed 175 patients NS-NSCLC from June 2010 to September 2013: 90 received treatment, 45 plus oxaliplatin, 40 carboplatin. Clinical was assessed using disease control rate (DCR), overall survival (OS),...
e20085 Background: Melanoma-associated antigen A1 (MAGE-A1) has been reported to perform oncogenically and act as an ideal candidate in tumor immunotherapy. Methods: One-step quantitative real-time polymerase chain reaction (qPCR) test immunohistochemistry (IHC) analysis were used detect the relationship between MAGE-A1 expression clinicopathological characteristics of lung adenocarcinoma (LAC). Then a novel IgG antibody was constructed on previous scFv by eukaryotic vectors. CCK-8, wound...