A5101868865- Acute Myeloid Leukemia Research
- Retinoids in leukemia and cellular processes
- Epigenetics and DNA Methylation
- Antioxidant Activity and Oxidative Stress
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Cancer Treatment and Pharmacology
- Drug-Induced Ocular Toxicity
- Cancer, Hypoxia, and Metabolism
- Kruppel-like factors research
- Cancer Mechanisms and Therapy
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Pharmacovigilance and Adverse Drug Reactions
- Drug-Induced Adverse Reactions
- Nanoplatforms for cancer theranostics
- Advanced Photonic Communication Systems
- Berberine and alkaloids research
- Lymphoma Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- RNA modifications and cancer
- Circular RNAs in diseases
- Chemotherapy-related skin toxicity
- CNS Lymphoma Diagnosis and Treatment
- Optical Coherence Tomography Applications
- PARP inhibition in cancer therapy
Huashan Hospital
2017-2025
Fudan University
2017-2025
Huazhong University of Science and Technology
2014-2024
Tongji Hospital
2020-2024
North Sichuan Medical University
2019-2024
Nanchong Central Hospital
2019-2024
Ruijin Hospital
2012-2024
Shanghai Jiao Tong University
2008-2024
Shanghai Institute of Hematology
1997-2024
University of Science and Technology of China
2021
HYPB is a human histone H3 lysine 36 (H3K36)-specific methyltransferase and acts as the ortholog of yeast Set2. This study explored physiological function mammalian using knockout mice. Homozygous disruption Hypb impaired H3K36 trimethylation but not mono- or dimethylation, resulted in embryonic lethality at E10.5-E11.5. Severe vascular defects were observed Hypb(-/-) embryo, yolk sac, placenta. The abnormally dilated capillaries mutant embryos sacs could be remodeled into large blood...
Significance The APL2012 trial is currently the largest randomized, multicenter clinical study of APL based on ATRA-ATO treatment with risk stratification. We enrolled 855 newly diagnosed patients during December 2012 to 2017 for careful follow-up. All received ATRA-ATO–based protocols remission induction. At consolidation phase, key part trial, ATO was used replace or reduce chemotherapy in a risk-stratified way. Patients were then treated as maintenance. results indicated not only...
Cefiderocol is a new drug class, which approved to treat Gram-negative bacteria infection. Its approval for marketing has provided clinicians with additional options treating antimicrobial resistant gram-negative infections. The aim of our study was assess the safety profiles cefiderocol in real-world through data mining United States Food and Drug Administration Adverse Event Reporting System (FAERS). We included adverse event (AE) reports regarding submitted FAERS from 2019 quarter 4...
Based on the wavelength transparency of Butler matrix (BM) beamforming network, we demonstrate a multi-beam optical phased array (MOPA) with an emitting aperture composed grating couplers at 1.55 μm pitch for wavelength-assisted two-dimensional beam-steering. The device is capable simultaneous operation in field view (FOV) 60° × 8° phased-array scanning axis and wavelength-tuning axis, respectively. typical beam divergence about 4° both axes. Using multiple linearly chirped lasers,...
A previous study by our group suggested that testis expressed 10 (Tex10) contributes to tumor progression promoting stem cell‑like features in hepatocellular carcinoma. However, the relevance of pluripotency factor Tex10 esophageal squamous cell carcinoma (ESCC) has remained elusive. The objective present was investigate role ESCC. For this purpose, mRNA and protein expression detected reverse transcription‑quantitative PCR, western blot analysis immunohistochemistry. In a loss‑of‑function...
Highlights•Huaier can be an effective drug to reduce oxaliplatin-induced hepatotoxicity.•ROS-mediated oxidative stress is involved in hepatotoxicity.•Huaier relieves liver stress.•Inhibition of PI3K pathway reverses the hepatoprotective effect Huaier.AbstractHepatotoxicity caused by anticancer medication oxaliplatin (OXA) significantly restricts its clinical use and raises risk damage. Huaier, a fungus found China, has been demonstrated have various beneficial effects adjuvant therapy for...
Bone marrow mesenchymal stem cells (BM‑MSCs) are important for postnatal angiogenesis and suitable use in construction of blood vessels by tissue engineering. The present study aimed to investigate the influence recombination signal binding protein immunoglobulin kappa J region (RBP‑JK) on differentiation BM‑MSCs into vascular endothelial cells, assess underlying mechanisms. were isolated identified flow cytometry. Lentiviral vectors encoding RBP‑JK shRNA (shRBPJK) constructed knockdown...
// Ni Fan 1,* , Lu Zhang Xiaoping Xu 1 Bobin Chen Zhu Pei Li Zi Tianling Ding Yan Ma Yuan and Zhiguang Lin Department of Hematology, Huashan Hospital, Fudan University, Shanghai, China Correspondence to: Xu, email: Chen, Keywords : PCNSL, methotrexate, idarubicin, PFS Received September 06, 2016 Accepted February 07, 2017 Published March 04, Abstract Primary central nervous system lymphoma (PCNSL) is a rare form non-Hodgkin with poor long-term survival. This study assessed methotrexate (MTX)...
Abstract Upon progression to the metastatic stage, prostate tumors commonly exhibit multi‐drug resistance. Combining multiple treatment protocols can be beneficial in overcoming this resistance, which is often attributed tumor heterogeneity. Recently, nano‐photosensitizer‐mediated photothermal therapy shown inhibit growth through pathways, including thermal ablation and activation of antitumor immune response. In study, gold nanoparticles (Au) are selected as core photosensitizer. Then,...
Hepatic sinusoidal obstruction syndrome (HSOS) is a serious side effect of oxaliplatin (OXA) treatment. The present study aimed to establish reproducible mouse model OXA‑induced HSOS and preliminarily explore the underlying molecular mechanisms using mRNA microarray analysis. A total 45 C57BL/6 male mice were randomly divided into five groups: Control, 5 mg/kg OXA, 10 15 OXA 20 OXA. respectively injected intraperitoneally with 5% glucose solution, or 5, 10, solution once week for 6...
Abstract ObjectivesSteroid-induced osteoporosis (SIOP) is a secondary osteoporosis, which systemic bone disease characterized by low mass, microstructure damage, increased fragility, and easy fracture. However, the specific mechanism remains unclear. Glucocorticoid-induced death of osteoblasts marrow mesenchymal stem cells (BMSCs) an important factor in SIOP. Ferroptosis iron-dependent programmed cell that differs from apoptosis, necrosis, autophagy, can be induced many factors. Herein, we...