A5100339427- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Cancer Research and Treatments
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Advanced biosensing and bioanalysis techniques
- Protease and Inhibitor Mechanisms
- Angiogenesis and VEGF in Cancer
- Lipid metabolism and disorders
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Virus-based gene therapy research
Harbin Medical University
2025
North China University of Science and Technology
2025
Fudan University
2012-2024
Capital Medical University
2024
Qingdao University
2017-2024
Affiliated Hospital of Qingdao University
2017-2024
Suzhou Municipal Hospital
2022-2024
Xuzhou Medical College
2021-2024
Guangdong University of Technology
2024
Nanjing Medical University
2017-2024
In this paper, a novel graphene oxide (GO)/sodium alginate (SA)/polyacrylamide (PAM) ternary nanocomposite hydrogel with excellent mechanical performance has been fabricated through free-radical polymerization of acrylamide (AAm) and SA in the presence GO an aqueous system followed ionically crosslinking calcium ions. As-prepared GO/SA/PAM (weight ratio : AAm = 1 2) 5 wt% displays compressive stress as high 1.543 MPa at deformation 70%. The tensile strength modulus achieved ∼201.7 ∼30.8 kPa,...
Abstract Cancer results from the concerted performance of malignant cells and stromal cells. Cell types populating microenvironment are enlisted by tumor to secrete a host growth-promoting cues, thus upholding initiation progression. Platelet-derived growth factors (PDGF) support formation prominent compartment as yet unidentified molecular effectors. Whereas PDGF-CC induces fibroblast reactivity fibrosis in range tissues, little is known about function shaping tumor-stroma interplay....
Angiopoietin-like protein 4 (ANGPTL4) plays complex and often contradictory roles in vascular biology tumor metastasis, but little is known about its function hepatocellular carcinoma (HCC) metastasis. In the present study, we showed that hypoxia-inducible factor 1α (HIF-1α) directly up-regulates ANGPTL4, stableness positively correlates with ANGPTL4 expression HCC tissue. Overexpression of significantly increased cell transendothelial migration vitro intrahepatic distal pulmonary metastasis...
HYPB is a human histone H3 lysine 36 (H3K36)-specific methyltransferase and acts as the ortholog of yeast Set2. This study explored physiological function mammalian using knockout mice. Homozygous disruption Hypb impaired H3K36 trimethylation but not mono- or dimethylation, resulted in embryonic lethality at E10.5-E11.5. Severe vascular defects were observed Hypb(-/-) embryo, yolk sac, placenta. The abnormally dilated capillaries mutant embryos sacs could be remodeled into large blood...
Lung fibrosis is a major medical problem for the aging population worldwide. Fibroblast migration plays an important role in fibrosis. Focal Adhesion Kinase (FAK) senses extracellular stimuli and initiates signaling cascades that promote cell migration. This study first examined dose time responses of FAK activation human lung fibroblasts treated with platelet derived growth factor BB (PDGF-BB). The data indicate directly recruited by integrin β1 subsequent required fibroblast on...
GLP and G9a are major H3K9 dimethylases essential for mouse early embryonic development. both harbor ankyrin repeat domains that capable of binding methylation. However, the functional significance their recognition methylation is unknown. Here, we report histone methyltransferase activities stimulated by neighboring nucleosomes premethylated at H3K9. These stimulation events function in cis dependent on G9a. Disruption methylation-binding activity mice causes growth retardation embryos,...
TCF12, which is known to be involved in the regulation of cell growth and differentiation, has been reported function as an oncogene or a tumor suppressor gene progression various malignant tumors. However, its molecular mechanism hepatocellular carcinoma (HCC) remain unclear. Methods: Stable ectopic TCF12 expression knockdown HCC lines was established by lentiviral infection. Then, MTT, colony formation, migration, invasion HUVECs tube formation assays well orthotopic xenograft model were...
Cancer stem cells (CSC) maintain both undifferentiated self-renewing CSCs and differentiated, non-self-renewing non-CSCs through cellular division. However, molecular mechanisms that self-renewal in versus are not yet clear. Here, we report a transgenic mouse model of MYC-induced T-cell leukemia, MYC, maintains Sca1+ Sca-1- non-CSCs. MYC preferentially bound to the promoter activated hypoxia-inducible factor-2α (HIF2α) Sca-1+ only. Furthermore, reprogramming factors, Nanog Sox2, facilitated...
AKR1C3 is an enzyme belonging to the aldo-ketoreductase family, members of which catalyze redox transformations involved in biosynthesis, intermediary metabolism, and detoxification. plays important role tumor progression metastasis, however, little known about function molecular mechanism underlying hepatocellular carcinoma (HCC). In this study, we report that significantly upregulated HCC increased associated with poor survival. positively regulated cell proliferation metastasis
The damage of integrated epithelial epithelium is a key pathogenic factor and closely associated with the recurrence ulcerative colitis (UC). Here, we reported that vanillic acid (VA) exerted potent therapeutic effects on DSS-induced by restoring intestinal homeostasis via inhibition ferroptosis. By CETSA assay DARTS assay, identified carbonic anhydrase IX (CAIX, CA9) as direct target VA. binding VA to CA9 causes insulin-induced gene-2 (INSIG2) interact stromal interaction molecule 1...
Background Head and neck cancers harbor dormant cancer stem cells (CSCs). This study explores how platinum therapy impacts these in a non-genetic manner the role of hypoxia this process. Previously, we identified novel population CSCs exhibiting an “altruistic” phenotype, sacrificing self-renewal to promote niche defense (tumor stemness defense, TSD), potentially protecting subpopulation CSCs, reawakening CSC (R-CSC) retaining stress memory. TSD phenotype involves activation MYC-HIF2α...
Bullous impetigo due to Staphylococcus aureus is one of the most common bacterial infections man, and its generalized form, staphylococcal scalded skin syndrome (SSSS), a frequent manifestation epidemics in neonatal nurseries. Both diseases are mediated by exfoliative toxins (ETs), which show exquisite pathologic specificity blistering only superficial epidermis. We that these act as serine proteases with extremely focused molecular cleave mouse human desmoglein 1 (Dsg1) once after glutamic...
CD133+ cancer stem cells (CSC) contribute to hepatocellular carcinoma (HCC) progression and resistance therapy. Bone morphogenetic protein BMP4 plays an important role in hepatogenesis hepatic cell differentiation, but little is known about its function CSCs. In this study, we showed that high-dose exogenous promotes HCC CSC differentiation inhibits the self-renewal, chemotherapeutic resistance, tumorigenic capacity of these cells. Interestingly, found low-dose upregulated CD133 expression...
MicroRNA-21 (miR-21) is an oncomiR that frequently upregulated in human cancers. AntimiR-21 (AM-21) oligonucleotide complementary to miR-21 designed inhibit its gene silencing activities. To facilitate efficient delivery of AM-21, a novel lipid nanoparticle formulation called QTsome, based on combination quaternary amine and tertiary cationic lipids, with distinctive pH-responsive profile, was developed. QTsome/AM-21 comprising DODMA/DOTAP/DOPC/CHOL/mPEG-DPPE AM-21 exhibited mean particle...
Hepatocellular carcinoma (HCC) is one of the most common malignant cancers with a high incidence and mortality in East Asia. Identifying biomarkers clarifying regulatory mechanisms HCC are great importance. Herein, we report role mechanism activating transcription factor 3 (ATF3), member ATF/cAMP-responsive element-binding protein family factors HCC. ATF3 overexpression vector shRNAs were transfected into cancer cells to upregulate or downregulate expression. In vitro vivo assays performed...
Abstract More than half of non‐muscle‐invasive bladder cancer (NMIBC) patients eventually relapse even if treated with surgery and BCG without optional bladder‐preserving therapy. This study aims to investigate the antitumor activity safety a HER2‐targeted antibody‐drug conjugate, RC48‐ADC, intravesical instillation for NMIBC treatment. In this preclinical study, it is revealed that human epidermal growth factor receptor 2 (HER2) expression scores 1+, 2+, 3+ are recorded 16.7%, 56.2%, 14.6%...
// Ji Sun 1, 2, * , Hong Li Qi Huo 2 Meiling Cui Chao Ge Fangyu Zhao Hua Tian Taoyang Chen 3 Ming Yao Jinjun 1 Shanghai Medical College, Fudan University, Shanghai, China State Key Laboratrory of Oncogenes and Related Genes, Cancer Institute, Renji Hospital, Jiaotong University School Medicine, Dong Liver Dong, Jiangsu Province, These authors contributed equally to this work Correspondence to: Li, email: jjli@shsci.org Keywords: FoxN3/CHES1, E2F5, hepatocellular carcinoma Received: April 04,...