Cancer stem cells (CSC) maintain both undifferentiated self-renewing CSCs and differentiated, non-self-renewing non-CSCs through cellular division. However, molecular mechanisms that self-renewal in versus are not yet clear. Here, we report a transgenic mouse model of MYC-induced T-cell leukemia, MYC, maintains Sca1+ Sca-1- non-CSCs. MYC preferentially bound to the promoter activated hypoxia-inducible factor-2α (HIF2α) Sca-1+ only. Furthermore, reprogramming factors, Nanog Sox2, facilitated...

The rapid and label-free diagnosis of malignancies in ex vivo breast biopsy tissues has significant utility pathology laboratories operating rooms. We report a MEMS-based platform integrated with microchips that performs phenotyping using electrothermal sensing. microchip, fabricated on silicon substrate, incorporates platinum microheater, interdigitated electrodes (IDEs), resistance temperature detectors (RTDs) as on-chip sensing elements. are onto the slide-fit contact enabling quick...

There have been substantial advancements in optical spectroscopy-based imaging techniques recent years. These developments can potentially herald a transformational change the diagnostic pathway for diseases such as cancer. In this paper, we review clinical and engineering aspects of novel tools. We provide comprehensive analysis non-optical breast cancer diagnosis vis-à-vis current standard X-Ray mammography, ultrasonography, tissue biopsy. The systems Transillumination Imaging (TI) various...

Gallbladder cancer (GBC) is an aggressive malignancy, with gallstone disease (GSD) recognized as the primary risk factor. Although precise mechanism linking GSD to GBC remains unclear, evidence suggests that characteristics play a significant role. This study investigates physicochemical of gallstones critical for development. We analyzed 40 samples from 30 and 10 (GBCGS) patients using advanced spectroscopic imaging techniques such fourier transform infrared (FTIR), powder X-ray diffraction...

Currently, the confirmation of diagnosis breast cancer is made by microscopic examination an ultra-thin slice a needle biopsy specimen. This conventionally formalin-fixed and stained with hematoxylin-eosin visually examined under light microscope. process labor-intensive requires highly skilled doctors (pathologists). In this paper, we report novel tool based on near-infrared spectroscopy (Spectral-IRDx) which portable, non-contact, cost-effective system could provide rapid accurate cancer....

Abstract Cancer stem cells (CSCs) constitute a minority cell population characterized by unbounded proliferative potential in both solid and hematological cancers. Despite sharing key attributes, CSCs possess unique traits, including the initiation propagation of tumors resistance to conventional therapies. The purpose this review is delve into origins fundamental characteristics CSCs, emphasizing their role tumor growth metastasis. focus extends unraveling cellular signaling pathways...

While performing surgical excision for breast cancer (lumpectomy), it is important to ensure a clear margin of normal tissue around the achieve complete resection. The current standard histopathology; however, time-consuming and labour-intensive requiring skilled personnel.We describe Hybrid Spectral-IRDx - combination previously reported tool with multimodal ultrasound NIR spectroscopy techniques. We show how this portable, cost-effective, minimal-contact could provide rapid diagnosis using...

There are various patient and professional factors responsible for the delay in start of treatment (SOT) head neck cancers (HNC).This retrospective study was conducted on data HNC patients registered at hospital cancer registry North-East India. All cases diagnosed during period January 2010 to December 2012 were considered present analysis. Educational levels all clustered into 3 groups; illiterates (unable read or write), qualified (school high school level education), highly (college...

Paragangliomas are rare neuroendocrine neoplasms arising in extra-adrenal chromaffin cells of autonomic nervous system and histologically akin to chemodectomas. They rare, affecting about 1 2,000,000 population. It is a generic term applied tumors paraganglia regardless the location. In instances, paragangliomas present around involve pancreas, thereby mimicking any one more common primary pancreatic lesions. Pancreatic paraganglioma an extremely tumor. grows slowly, so radical resection...

This study aimed at analysing the effects of coconut (

Profile of molecular subtypes breast cancer with special reference to triple negative:A study from Northeast India therapy.Current routine clinical management BC relies on the availability robust and pathological prognostic predictive factors support patient decision-making in which potentially suitable treatment options are increasingly available.The traditional staging basis tumor size lymph node status remains cornerstone outcome indicators; it has become clear that not all s presenting...

Background: Cancers of the breast, uterine cervix and ovary are common cancers amongst females North East India. Not much is known about descriptive epidemiology these in our population. The present retrospective analysis was therefore performed. Materials Methods: data set available at hospital based cancer registry a regional center North-East India, containing information on patients registered during period January 2010 to December 2012, applied. A total 2,925 cases ovarian were...

Schwannomas constitute one of the most common benign peripheral nerve sheath tumors. can occur anywhere in body occasionally with unusual presentation. FNB does not appear to provide an accurate preoperative diagnosis. Complete excision mass should be goal surgical excision. In this case series, we studied various clinicomorphological features schwannomas for duration year. Immunostaining were done using anti-S100 protein and a panel antibody confirm diagnosis cases as well whose...

The main objective of this paper was to assess the influence educational level on survival uterine cervix cancer patients in our population. A total 224 were registered registry, which 178 had information stage and different levels. overall median (MS) 23 months, with values 18.5, 20.7 41.3 months for illiterate, literate qualified groups, respectively. In illiterate patients, I seen 2.6% IV 11.8%, while other 2 groups 10% 17% at time diagnosis. probability around 50 42%, 30% 26%...

Papillary carcinoma of the breast is a rare malignant tumor, constituting 1%-2% all carcinomas in women. We studied total 6 cases papillary cancer which five were female patients, and one was male patient. Three invasive while encapsulated without invasion, with invasion solid type carcinoma. The median age patients 45.5 years. All tumors except seen left breast. Grossly, size ranged from 2 cm × 1.5 to as large 10 4 cm. had positive axillary nodes. To conclude, tumor better prognosis...

Frontline healthcare workers (HCWs) are repeatedly exposed to SARS-CoV-2 and chance of exposure it invariably high than any other category population. In this study, we investigated suspected cases reinfection among eight HCWs involved in COVID-19 duty Dibrugarh, Assam. Diagnosis was done by Real Time RT-PCR or Rapid Antigen Detection Test at AMCH, Dibrugarh ICMR-RMRC, Dibrugarh. Cases who tested positive for RAT the second time with symptoms suggestive were included investigation as...

Adrenocortcal carcinoma is an extremely uncommon entity with incidence of two in one millionth population. Here we present a 60 year gentleman pain abdomen, nausea, and backache, weight loss. Contrast enhanced computed tomography (CECT) abdomen revealed heterogenous well defined mass measuring (15 × 10.3 13) cm(3) on the left suprarenal region central necrosis which extended medially up to midline. Locally, growth infiltrated upper pole kidney. Initially, differential diagnosis included that...

COVID-19 an infectious disease caused by the SARS-CoV-2 virus, started in late 2019 and became a pandemic within short period. To respond to vaccines like Covishield, Covaxin, Sputnik V, Covovax, etc., were developed rapidly. However, there raising concerns about development of immunity as well adverse events following vaccination.

Invasive lobular carcinoma (ILC) is the second most common special subtype of invasive breast comprising 5–15%. ILC defines as non-cohesive single-file linear pattern in fibrous stroma. The aim study was to evaluate histomorphological features and immunohistochemical analysis ILC. A total 19 cases were encountered from March 2020 February 2024 out 129 cancers. sociodemographic profiles clinicopathological parameters patients studied with emphasis on their morphology hormone receptor status....

Abstract: BACKGROUND: In India, cervical cancer is the second most prevalent among women, constituting 18.3% of all cases. Persistent high-risk human papillomavirus (HPV) infection a well-established risk factor for cancer. OBJECTIVES: This study aimed to assess prevalence 14 HPV subtypes and their association with abnormal cytology women in Upper Assam. MATERIALS AND METHODS: descriptive cross-sectional was conducted from February 2022 April 2023 at tertiary care center A total 100 aged...

Invasive lobular carcinoma (ILC) is the second most common special subtype of invasive breast comprising 5–15%. ILC defines as non-cohesive single-file linear pattern in fibrous stroma. The aim study was to evaluate histomorphological features and immunohistochemical analysis ILC. A total 19 cases were encountered from March 2020 February 2024 out 129 cancers. sociodemographic profiles clinicopathological parameters patients studied with emphasis on their morphology hormone receptor status....

Background: There are so many factors that cared of during the antenatal period, Jaundice is one them and very important one.Aim current study was to know etiological jaundice among pregnant patients, outcome their management.Methods: This done in Department Obstetrics & Gynaecology, Era's Lucknow Medical College Hospital patients with admitted obstetric wards labour room 6 months duration from January 2016 June 2016.Results: Among total admissions, 65 presented jaundice.Out all admissions...