A5067462572- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Plant-derived Lignans Synthesis and Bioactivity
- Polysaccharides and Plant Cell Walls
- Phytochemistry and Bioactive Compounds
- Traditional and Medicinal Uses of Annonaceae
- Bioactive natural compounds
- Immune Response and Inflammation
- Nephrotoxicity and Medicinal Plants
- Traditional Chinese Medicine Analysis
- Drug-Induced Hepatotoxicity and Protection
- X-ray Diffraction in Crystallography
- Pharmacological Effects of Natural Compounds
- Crystallization and Solubility Studies
- Bioactive Natural Diterpenoids Research
- Phytochemical Studies and Bioactivities
- Sphingolipid Metabolism and Signaling
- Biological Activity of Diterpenoids and Biflavonoids
- Plant Toxicity and Pharmacological Properties
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ginseng Biological Effects and Applications
- Toxin Mechanisms and Immunotoxins
- Glycosylation and Glycoproteins Research
- Plant-based Medicinal Research
- Phytochemical compounds biological activities
Fudan University
2016-2025
Jiangxi University of Traditional Chinese Medicine
2024
China Pharmaceutical University
1992-2023
Second People’s Hospital of Yibin
2022
Anqing Normal University
2009
Southeast University
2007
GTx (United States)
2005
Shanghai Institute of Materia Medica
1996
The mass spectrometric (MS) analysis of flavone di‐ C ‐glycosides has been a difficult task due to pure standards being unavailable commercially and that the reported relative intensities some diagnostic ions varied with MS instruments. In this study, five ‐glycoside from Viola yedoensis have systematically studied by high performance liquid chromatography‐electrospray ionization‐tandem ion trap spectrometry (HPLC‐ESI‐IT‐MS n ) in negative mode analyze their fragmentation patterns. A new 2 3...
Two new lignans, interiotherins A (1) and B (2), along with two known angeloylgomisin R (3) schisantherin D (4), were isolated from Kadsura interior. Their structures stereochemistries determined spectral data. Compounds 1 4 inhibit HIV replication EC50 values of 3.1 0.5 μg/mL, respectively.
Houttuynia cordata Thunb. is a traditional herb used for clearing heat and eliminating toxins, has also been the treatment of severe acute respiratory syndrome (SARS). In vitro, crude H. polysaccharides (CHCP) exhibited potent anti-complementary activity through both classical alternative pathways by acting on components C3 C4 complement system without interfering with coagulation system. This study was to investigate preventive effects CHCP lung injury (ALI) induced hemorrhagic shock plus...
Intestinal stem cell (ISC) is a promising therapeutic target for inflammatory bowel disease. Cholesterol availability critical ISC stemness. Low plasma cholesterol typical feature of Crohn's disease (CD); however, its impact on mucosal healing remains unclear. Here, we identified an essential role sorting nexin 10 (SNX10) in maintaining the stemness ISCs. SNX10 expression intestinal tissues positively correlates with severity human CD and mouse colitis. Conditional knockout epithelial cells...
Three new triterpene lactones, lancilactones A (1), B (2), and C (3), together with the known kadsulactone (4), were isolated from stems roots of Kadsura lancilimba. Their structures stereochemistries determined primarily mass NMR spectral data. Compound 3 inhibited HIV replication an EC50 value 1.4 μg/mL a therapeutic index greater than 71.4.