A5023778284- Cancer-related molecular mechanisms research
- Traditional Chinese Medicine Analysis
- Advanced Photocatalysis Techniques
- Metabolomics and Mass Spectrometry Studies
- 2D Materials and Applications
- Immune Response and Inflammation
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Glycation End Products research
- Chronic Kidney Disease and Diabetes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Perovskite Materials and Applications
- Plant-based Medicinal Research
- Mycobacterium research and diagnosis
- Inflammasome and immune disorders
- Computational Drug Discovery Methods
- Catalytic Processes in Materials Science
- Ferroptosis and cancer prognosis
- Medicinal Plant Pharmacodynamics Research
- Neurological Disease Mechanisms and Treatments
- Bioinformatics and Genomic Networks
- RNA modifications and cancer
- Natural product bioactivities and synthesis
- Gout, Hyperuricemia, Uric Acid
- Electromagnetic wave absorption materials
- Dermatological and Skeletal Disorders
Anhui University of Traditional Chinese Medicine
2009-2025
Sichuan University
2025
West China Hospital of Sichuan University
2025
Nanjing University of Chinese Medicine
2024
Barro Colorado Island
2023
Hunan University
2020-2022
Fudan University
2015-2022
Pudong Medical Center
2022
Nanjing University of Aeronautics and Astronautics
2019-2020
Wuhan Polytechnic University
2020
LncRNA OIP5-AS1 has a common gene imbalance in various cancers and tumours, which plays an important role regulating its biological function. However, there are few studies on lncRNA rheumatoid arthritis (RA). The purpose of the present study was to investigate pathogenesis RA. In study, we established adjuvant (AA) rat model obtain primary fibroblast-like synoviocytes (FLSs);The subcellular localisation detected by fluorescence situ hybridisation (FISH) assay; Cell proliferation FLSs...
Abstract Background and aims Recent studies have shown that intestinal flora are involved in the pathological process of ischemic stroke (IS). The potential protective effect traditional Chinese prescription, Tao Hong Si Wu Decoction (THSWD), against inflammatory injury after IS its underlying mechanisms action were investigated current study. Methods Fifty SPF(Specefic pathogen Free) male C57 mice randomly assigned to sham operation, model, THSWD low-dose (6.5 g/kg), medium-dose (13 g/kg)...
We report a patient diagnosed for SFM with variant in the FEFR2 gene. The clinical presentation of skin fold changes was different from that other gene variants causing disease, showing specific changes. In patients folds, evaluation FGFR2 should be considered.
Taohong Siwu decoction (THSWD) is a classic traditional Chinese medicine (TCM) prescription that widely used in the clinical treatment of gynecological and cerebrovascular diseases. Here we method coupled ultra-performance liquid chromatography to quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) which both positive negative ion modes were established investigate major constituents THSWD. A Waters ACQUITY UPLC BEH C18 column (2.1 mm×100 mm, 1.7 μm) was separate aqueous extract The...
Abstract Taohong Siwu Decoction is a classic Chinese medicine prescription for treatment of cerebral ischemia and gynecological diseases. However, the active ingredients have not been identified. In this study, ultra performance liquid chromatography quadrupole time‐of‐flight mass system was used to analyze components metabolites absorbed into blood brain. A total 39 compounds 90 were identified in brain by comparing retention times, accurate masses, fragmentation patterns, literature data....
Cell necrosis and neuroinflammation play an important role in brain injury induced by ischemic stroke. Previous studies reported that Taohong Siwu decoction (THSWD)can reduce heart muscle cell has anti-inflammatory properties. In this study, we investigated the effects of THSWD on a rat model middle cerebral artery occlusion (MCAO). Thirty-six male Sprague-Dawley (SD) rats were randomly divided into three groups with 12 each group. They sham operation group, MCAO + We used ELISA to determine...
Bronchial asthma (BA) is a chronic inflammatory disease of the airway. Previous research has shown that Yanghe Pingchuan granules (YPGs) exert precise therapeutic effect on BA. In our previous work, we showed YPGs improved inflammation airways in rat models Other studies have pathogenesis BA closely related to pyroptosis and TOLL-like receptor pathway plays key role mediation pyroptosis. Therefore, present study, established model by applying concept used TLR4/NF-κB/NRLP3 signaling as target...
Tao Hong Si Wu Decoction (THSWD) is a well-known traditional Chinese medicine used clinically alone or combined with drugs to treat breast cancer. However, there has been no study date on the underlying mechanisms of its therapeutic effects.
Abstract Ferroelectric photovoltaic materials have attracted great attention because of their unique photoelectric conversion mechanism, high photo-generated voltage, and adjustable polarization intensity. Traditional ferroelectric oxide perovskites such as BaTiO 3 , BiFeO Pb(ZrTi)O much but they are not suitable light absorbing layers in solar cells, due to the large optical bandgap, low absorption rate, small photogenerated current. Therefore, it is necessary seek prominent with both band...
Diabetes mellitus is related to low-grade chronic inflammation and oxidative stress. Bupleurum Polysaccharides (BPs), isolated from smithii var. parvifolium has anti-inflammatory anti-oxidative properties. However, little known about its therapeutic effects on diabetes. In this experiment, the of BPs alleviation diabetes underlying mechanisms were investigated. Diabetic mice model was established via successive intraperitoneal injections streptozotocin (100 mg/kg body weight) for two days....
Rheumatoid arthritis (RA) is the most common autoimmune disease and affects multiple joints. Previous studies have shown that total saponins of Radix clematidis (TSC) a clear therapeutic effect on RA, but specific mechanism has not yet been clarified. Literature screening previous research suggest lncRNA OIP5-AS1/miR-410-3p/Wnt7b signaling pathway exerts regulatory pathogenesis RA. In this study, we examined whether TSC treatment RA pathway.Freund's complete adjuvant was used to create an...
Abstract Background Yanghe Pingchuan decoction (YPD) has been used for asthma treatment many years in China. We sought to understand the mechanism of YPD, and find more potential targets YPD-based asthma. Methods An ovalbumin-induced model rats was created. Staining (hematoxylin eosin, Masson) evaluate effect YPD. RNA-sequencing carried out analyze global gene expression, differentially expressed genes (DEGs) were identified. Analysis functional enrichment done using Gene Ontology database...
Previously, we demonstrated that Rhizoma Paridis saponins (RPS), the major active component of Paridis, may exhibit hepatoprotective effects. The present study aimed to identify potential mechanism RPS on hepatic injury and improvement in fibrosis (HF). A HF model was created Sprague‑Dawley rats by administration carbon tetrachloride. administered for treatment following creation model. protein mRNA expression vascular endothelial growth factor (VEGF), platelet‑derived (PDGF), extracellular...
Abstract For epidemic prevention and control, the identification of SARS-CoV-2 subpopulations sharing similar micro-epidemiological patterns evolutionary histories is necessary for a more targeted investigation into links among COVID-19 outbreaks caused by with genetic backgrounds. Genomic sequencing analysis has demonstrated ability to uncover viral diversity. However, an objective subpopulations. Herein, we detected all mutations in 186 682 isolates. We found that GC content genome had...
The three-dimensional (3D) organic-inorganic halide perovskite MAPbI3 has excellent light-harvesting properties but is unstable. However, the newly synthesized two-dimensional (2D) all-inorganic Ruddlesden-Popper (RP) Cs2PbI2Cl2 superior stability adverse photoelectric properties. Therefore, constructing a 2D Cs2PbI2Cl2/3D heterostructure expected to combine superstability of material and high efficiency 3D one. charge transfer heterostructures are investigated using density functional...