A5100444063- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Neurological Disorders and Treatments
- Tryptophan and brain disorders
- Neurogenesis and neuroplasticity mechanisms
- Magnetism in coordination complexes
- Luminescence Properties of Advanced Materials
- Acute Ischemic Stroke Management
- Crystal Structures and Properties
- Advanced Chemical Physics Studies
- Solid-state spectroscopy and crystallography
- Electronic and Structural Properties of Oxides
- Immune cells in cancer
- Functional Brain Connectivity Studies
- Migraine and Headache Studies
- Cancer-related molecular mechanisms research
- Mosquito-borne diseases and control
- Stress Responses and Cortisol
- Barrier Structure and Function Studies
- Cerebrovascular and Carotid Artery Diseases
- ZnO doping and properties
- Advanced Condensed Matter Physics
- Glass properties and applications
- Lanthanide and Transition Metal Complexes
- Ginkgo biloba and Cashew Applications
Southwest Minzu University
2025
State Ethnic Affairs Commission
2025
University of Electronic Science and Technology of China
2015-2024
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2019-2024
Wuhan University
2024
Harbin Medical University
2024
Second Affiliated Hospital of Harbin Medical University
2024
Anhui University of Traditional Chinese Medicine
2024
State Key Laboratory of Medical Neurobiology
2021-2023
Fudan University
2021-2023
Adult neurogenesis in the dentate gyrus of hippocampus is regulated by specific microglia groups and functionally implicated behavioral responses to stress. However, role hippocampal stress resilience remains unclear. We identified interleukin 4 (IL4)-driven characterized high expression Arg1, which critical maintaining resistance. Decreasing Arg1+ knocking down microglial IL4R suppressed enhanced vulnerability. Increasing enhancing IL4 signaling restored stress-induced depression....
Human granulocytic anaplasmosis (HGA) is an emerging tick-borne disease in China. A cluster of cases among health care workers and family members following exposure to a patient with fulminant consistent HGA prompted investigation.To investigate the origin transmission apparent nosocomial febrile illness Anhui Province.After index whose fatal was characterized by fever hemorrhage at primary hospital regional tertiary hospital's isolation ward, secondary who were suspected being exposed...
Neuroinflammation driven by interferon-gamma (IFN-γ) and microglial activation has been linked to neurological disease. However, the effects of IFN-γ-activated microglia on hippocampal neurogenesis behavior are unclear. In present study, IFN-γ was administered mice via intracerebroventricular injection. Mice received intraperitoneal injection ruxolitinib inhibit JAK/STAT1 pathway or minocycline activation. During a 7-day period, were assessed for depressive-like behaviors cognitive...
Anti-inflammatory approaches are emerging as a new strategy for the treatment of depressive disorders. Ginsenoside Rb1 (GRb1), major component Panax ginseng, can inhibit inflammatory cascade and alleviate depressive-like behaviors. Microglia promote or adult hippocampal neurogenesis according to their functional phenotypes. Here, we examine whether GRb1 may exert antidepressant effects by promoting pro-neurogenic phenotype microglia thereby increasing neurogenesis.The licensed imipramine...
Abstract Background and aims Recent studies have shown that intestinal flora are involved in the pathological process of ischemic stroke (IS). The potential protective effect traditional Chinese prescription, Tao Hong Si Wu Decoction (THSWD), against inflammatory injury after IS its underlying mechanisms action were investigated current study. Methods Fifty SPF(Specefic pathogen Free) male C57 mice randomly assigned to sham operation, model, THSWD low-dose (6.5 g/kg), medium-dose (13 g/kg)...
Background COVID-19 is generally believed to increase the risk of nosocomial infections, however, there a gap in relevant researches on critically ill patients cardiac care units (CCU). Method This cross-sectional research was conducted tertiary-level non-epidemic hospital Beijing, capital China. The infection rates CCU were assessed prior and during outbreak. Results During pandemic, overall incidence infections decreased by 20.6-percent compared with pre - pandemic period. Specifically,...
Background and objective: Vascular dementia (VaD) Alzheimer's disease (AD) could be characterized by the same syndrome of dementia. This study aims to assess whether multi-parameter features derived from structural MRI can serve as informative biomarker for differential diagnosis VaD AD using machine learning. Methods: A total 93 patients imaged with brain including 58 35 confirmed two chief physicians were recruited in this June 2013 July 2019. Automated tissue segmentation was performed...
Abstract High‐resolution fluid dispensing techniques play a critical role in modern digital microfluidics, micro‐biosensing, and advanced fabrication. Though most of existing dispensers can achieve precise high‐throughput dispensing, they suffer from some inherent problems, such as specially fabricated micronozzles/microtips, large operating systems, low volume tunability, poor performance for surface tension liquids containing solid/liquid additives. Herein, the authors propose facile,...
We aimed to investigate the effects of Panax notoginseng saponins (PNS) on proliferation, differentiation and self-renewal rat hippocampal neural stem cells (NSCs) in vitro. Rat NSCs were isolated from post-natal day 1 (P1) rats cultured a serum-free medium. The neurospheres identified by expressions nestin, class III β-tublin (Tuj-1) glial fibrillary acid protein (GFAP). given PNS subjected oxygen glucose deprivation (OGD) as an vitro model brain ischemia reperfusion. proliferation was...
The morphology of microglial cells is often closely related to their functions. mechanisms that regulate ramification are not well understood. Here we reveal the biological by which astrocytes ramification. Morphological variation in mouse cultures was measured terms cell area as branch number and length. Effects on were analyzed after microinjecting toxin L-alpha-aminoadipic acid (L-AAA) cortex or hippocampus ablate astrocytes, culturing microglia own an astrocyte-conditioned medium (ACM)...
Microglia cells (MGCs) play a key role in scavenging pathogens and phagocytosing cellular debris the central nervous system retina. Their activation, however, contributes to progression of multiple degenerative diseases. Given potential damage created by MGCs, it is important better understand their mechanism activation. Here, we explored MGCs context retinitis pigmentosa (RP) using four independent preclinical mouse models. For therapeutic modeling, tamoxifen-inducible CreER was introduced...
Abstract Adult neurogenesis in the dentate gyrus of hippocampus is regulated by specific groups microglia and functionally implicated behavioral responses to stress. However, role modulating hippocampal stress remains poorly understood. Here we investigated effects IL4-driven Arg1 + restoration conferment resilience. We found that low IL4 levels mice was associated with greater vulnerability and, conversely, overexpression induced a large number ameliorated stress-induced depressive-like...