A5006628583- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neurogenesis and neuroplasticity mechanisms
- Dermatology and Skin Diseases
- Neonatal and fetal brain pathology
- Maternal Mental Health During Pregnancy and Postpartum
- Pharmacological Effects of Natural Compounds
- Asthma and respiratory diseases
- Neuroendocrine regulation and behavior
- Pain Mechanisms and Treatments
- Gene expression and cancer classification
- Memory and Neural Mechanisms
- Infant Development and Preterm Care
- Prenatal Substance Exposure Effects
- Pregnancy and preeclampsia studies
- Ginseng Biological Effects and Applications
- Cell Image Analysis Techniques
- Pregnancy and Medication Impact
- Immune cells in cancer
- Genetics and Neurodevelopmental Disorders
- Single-cell and spatial transcriptomics
- Anesthesia and Neurotoxicity Research
- Reproductive System and Pregnancy
- Neuroscience and Neuropharmacology Research
Air Force Medical University
2022-2025
University of Southern California
2019-2024
University of California, Los Angeles
2024
University of Electronic Science and Technology of China
2011-2021
Chengdu University
2021
Adult neurogenesis in the dentate gyrus of hippocampus is regulated by specific microglia groups and functionally implicated behavioral responses to stress. However, role hippocampal stress resilience remains unclear. We identified interleukin 4 (IL4)-driven characterized high expression Arg1, which critical maintaining resistance. Decreasing Arg1+ knocking down microglial IL4R suppressed enhanced vulnerability. Increasing enhancing IL4 signaling restored stress-induced depression....
Discoveries that microglia-mediated neuroinflammation is involved in the pathological process of depression provided a new strategy for novel antidepressant therapy. Peroxisome proliferator-activated receptor γ (PPARγ) nuclear regulating inflammation and microglial polarization and, therefore, potential target resolving depressive disorders. Our hypothesis was effects could be achieved through anti-inflammatory neuroprotective activities by PPARγ-dependent microglia-modulating agents....
Abstract Despite the potential adverse effects of maternal sleep deprivation (MSD) on physiological and behavioral aspects offspring, mechanisms remain poorly understood. The present study was intended to investigate roles microglia neurodevelopment cognition in young offspring rats with prenatal deprivation. Pregnant Wistar received 72 h last trimester gestation their prepuberty male were given intraperitoneal injection or without minocycline. results showed number Iba1 + increased, that...
Anti-inflammatory approaches are emerging as a new strategy for the treatment of depressive disorders. Ginsenoside Rb1 (GRb1), major component Panax ginseng, can inhibit inflammatory cascade and alleviate depressive-like behaviors. Microglia promote or adult hippocampal neurogenesis according to their functional phenotypes. Here, we examine whether GRb1 may exert antidepressant effects by promoting pro-neurogenic phenotype microglia thereby increasing neurogenesis.The licensed imipramine...
Significance This study demonstrates that maternal inflammation during pregnancy perturbs blood–brain barrier formation via cyclooxygenase activation in fetal microglia, leading to abnormal cerebrovascular function and chronic brain persisting across the offspring life span. Therefore, developmental disruption of could be an important etiological factor contributing pathology neurodevelopmental disorders.
Pain and itch are intricately entangled at both circuitry behavioral levels. Emerging evidence indicates that parvalbumin (PV)-expressing neurons in zona incerta (ZI) critical for promoting nocifensive behaviors. However, the role of these modulation remains elusive. Herein, by combining FOS immunostaining, fiber photometry, chemogenetic manipulation, we reveal ZI PV act as an endogenous negative diencephalic modulator processing. Morphological data showed histamine chloroquine stimuli...
Natural products have been widely reported as effective therapeutic alternatives for treatment of depression. Sanyuansan is a compound recipe composed ginseng total saponins, fish oil, and valeriana. The aims this study were to validate whether has antidepressant-like effects through acute behavioral tests including the forced swimming test (FST), tail suspension (TST), locomotor activity test, chronic mild stress (CMS) mice model C57BL/6 given oral administration 30 mg/kg imipramine,...
Abstract Adult neurogenesis in the dentate gyrus of hippocampus is regulated by specific groups microglia and functionally implicated behavioral responses to stress. However, role modulating hippocampal stress remains poorly understood. Here we investigated effects IL4-driven Arg1 + restoration conferment resilience. We found that low IL4 levels mice was associated with greater vulnerability and, conversely, overexpression induced a large number ameliorated stress-induced depressive-like...
Human epidemiological and animal-model studies suggest that separate exposure to stress or serotonin-selective reuptake inhibitor (SSRI) antidepressants during pregnancy increases risks for neurodevelopmental disorders in offspring. Yet, little is known about the combined effects of maternal SSRIs with regard brain development utero. We found placenta highly permeable commonly prescribed SSRI (±)-citalopram (CIT) humans mice, allowing rapid fetal this drug. investigated chronic unpredictable...
Astrocytic glycogen plays an important role in brain energy metabolism. However, the contribution of metabolism to stress-induced depression remains unclear. Chronic social defeat stress was used induce depression-like behaviors mice, assessed with behavioral tests. Glycogen concentration medial prefrontal cortex (mPFC) and expression key enzymes were investigated using Western blots, immunofluorescent staining, electron microscopy, biochemical assays. Stereotaxic surgery viral-mediated gene...
Abstract Despite remarkable progress in understanding the fundamental bases of itching, its cortical mechanisms remain poorly understood. Herein, causal contributions defined anterior cingulate cortex (ACC) neuronal populations to acute itch modulation mice are established. Using cell type‐specific manipulations, opposing functions ACC glutamatergic and GABAergic neurons regulating itching demonstrated. Photometry studies indicated that activated during scratching induced by both histamine...
Abstract Genetic variation can alter brain structure and, consequently, function. Comparative statistical analysis of mouse brains across genetic backgrounds requires spatial, single-cell, atlas-scale data, in replicates—a challenge for current technologies. We introduce A tlas-scale T ranscriptome L ocalization using ggregate S ignatures (ATLAS), a scalable tissue mapping method. ATLAS learns transcriptional signatures from scRNAseq encodes them situ with tens thousands oligonucleotide...
Abstract BackgroundAnti-inflammatory approaches are emerging as a new strategy for treatment of depressive disorders. Ginsenoside Rb1 (GRb1), major component Panax ginseng, can inhibit inflammatory cascade and alleviate behaviors. Microglia promote or adult hippocampal neurogenesis according to their functional phenotypes. Here, we examined whether GRb1 may exert antidepressant effects by promoting pro-neurogenic phenotype microglia thereby increasing neurogenesis. MethodsThe the licensed...