A5003291607- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Liver Disease Diagnosis and Treatment
- Stress Responses and Cortisol
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Electrocatalysts for Energy Conversion
- MicroRNA in disease regulation
- Genetics and Neurodevelopmental Disorders
- Nerve injury and regeneration
- Neuroendocrine regulation and behavior
- Cancer, Stress, Anesthesia, and Immune Response
- Aldose Reductase and Taurine
- Liver Disease and Transplantation
- Circular RNAs in diseases
- Dermatology and Skin Diseases
- Advanced battery technologies research
- Mechanisms of cancer metastasis
- Hepatitis B Virus Studies
- Tryptophan and brain disorders
- Advanced Photocatalysis Techniques
- Copper-based nanomaterials and applications
- Genomics, phytochemicals, and oxidative stress
- Cancer-related cognitive impairment studies
- Milk Quality and Mastitis in Dairy Cows
Air Force Medical University
2014-2024
Xijing Hospital
2012-2024
First Affiliated Hospital of Xi'an Jiaotong University
2022
Sun Yat-sen University
2022
Patients with neuropathic pain often experience comorbid psychiatric disorders. Cellular plasticity in the anterior cingulate cortex (ACC) is assumed to be a critical interface for perception and emotion. However, substantial efforts have thus far been focused on intracellular mechanisms of rather than extracellular alterations that might trigger facilitate changes. Laminin, key element matrix (ECM), consists one α-, β-, γ-chain implicated several pathophysiological processes. Here, we...
The anterior cingulate cortex (ACC) is a critical hub for nociceptive perception and pain-related anxiety. Long-term synaptic plasticity in ACC was found to be important chronic inflammatory pain As short-term plasticity, depolarization-induced suppression of excitation (DSE) involved several conditions, such as stress, epilepsy, autism. However, it still unknown whether DSE the central sensitization Using whole-cell patch clamp, calcium imaging, western blot, behavioral testing, we that...
Transjugular intrahepatic portosystemic shunt (TIPS) represents a major advance in the treatment of complications portal hypertension. However, this procedure is contraindicated hepatocellular carcinoma (HCC) patients with vein tumor thrombosis (PVTT). This study aims to evaluate safety and efficacy TIPS these hypertension determine predictors survival after creation.Between 2005 2011, 58 consecutive HCC symptomatic concomitant PVTT underwent placement. Procedure-related complications, were...
Glutamate is a prominent neurotransmitter responsible for excitatory synaptic transmission and taken up by sodium-dependent amino acid transporters (EAATs) on astrocytes to maintain homeostasis. Here, we report that N-myc downstream regulated gene 2 (NDRG2), known tumor suppressor, required facilitate astroglial glutamate uptake protect the brain from excitotoxicity after ischemia. NDRG2 knockout (Ndrg2−/−) mice exhibited an increase in cerebral interstitial reduction into astrocytes. The...
Pain and itch are intricately entangled at both circuitry behavioral levels. Emerging evidence indicates that parvalbumin (PV)-expressing neurons in zona incerta (ZI) critical for promoting nocifensive behaviors. However, the role of these modulation remains elusive. Herein, by combining FOS immunostaining, fiber photometry, chemogenetic manipulation, we reveal ZI PV act as an endogenous negative diencephalic modulator processing. Morphological data showed histamine chloroquine stimuli...
Paclitaxel is widely used as a first-line chemotherapy agent to treat malignant tumors. However, paclitaxel causes peripheral nerve fiber damage and neuropathic pain in some patients. In addition, patients received are often accompanied by negative emotions such anxiety. The amygdala critically involved regulating signals, well purpose of this study clarify the role Ca2+/calmodulin-dependent protein kinase II (CaMKII)-positive glutamatergic neurons paclitaxel-induced affective symptoms....
Bone cancer pain (BCP) is one of the most difficult and intractable tasks for management, which associated with spinal 'neuron-astrocytic' activation. The activation c-Jun N-terminal kinase (JNK)/chemokine (C-C motif) ligand (CCL2) signaling pathway has been reported to be critical neuropathic pain. Rolipram (ROL), a selective phosphodiesterase 4 inhibitor, possesses potent anti-inflammatory anti-nociceptive activities. present study aimed investigate whether intrathecal administration ROL...
Abnormal amino acid metabolism in neural cells is involved the occurrence and development of major depressive disorder. Taurine an important required for brain development. Here, microdialysis combined with metabonomic analysis revealed that level taurine extracellular fluid cerebral medial prefrontal cortex (mPFC) was significantly reduced mice chronic social defeat stress (CSDS)-induced depression. Therefore, supplementation may be usable intervention We found effectively rescued...
Chronic sleep deprivation (SD) is a common problem for humans and can lead to many deleterious effects, including depression, anxiety, stroke, permanent cognitive deficits, stress, other physiological diseases. It vital acquire information about the relevant neural activities at whole-brain level systematically explore mechanisms of brain dysfunction related SD. Expression immediate-early gene (IEG)
Background . Acute variceal bleeding is a major cause of death in liver cirrhosis. This large scale retrospective cohort study aims to analyze the prognosis patients with cirrhosis and acute validate current prognostic models. Methods Patients were enrolled from Jan 2019 March 2020. The independent factors for in-hospital identified by logistic regression analyses. Area under curves (AUCs) was compared among Child-Pugh, gastrointestinal (CAGIB) score, model end-stage disease (MELD)...
Brain edema is a grave complication of brain ischemia and the main cause herniation death. Although astrocytic swelling contributor to cytotoxic edema, molecular mechanism involved in this process remains elusive. N-myc downstream-regulated gene 2 (NDRG2), well-studied tumor suppressor gene, mainly expressed astrocytes mammalian brains. Here, we found that NDRG2 deficiency leads worsened cerebral imbalanced Na+ transfer, astrocyte after ischemia. We also deletion dramatically changed...
Abstract The recurrence rate of lymphoma is very high, and tumor stem cells may be an important mechanism. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) can inhibit antitumor immunity promote cancer progression, but its role mechanism in are still unclear. Here we collected tissue peripheral blood from patients with diffuse large B-cell (DLBCL). Results showed that CTLA-4 expression CD44+ cell the high-risk group were significantly higher than low-risk group. Correlation analysis...
Neuropathic pain (NP) is a complex, chronic condition caused by injury or dysfunction affecting the somatosensory nervous system. This study aimed to identify crucial mRNAs and microRNAs (miRNAs) in prelimbic cortex (PL) of NP rats. mRNA miRNA microarrays were applied present study. The miRNA-mRNA regulatory network was constructed using ingenuity pathway analysis (IPA). A total 35 differentially expressed (DE) RNAs (24 miRNAs 10 mRNAs) identified spared nerve (SNI) group compared with...
Astrocytic glycogen plays an important role in brain energy metabolism. However, the contribution of metabolism to stress-induced depression remains unclear. Chronic social defeat stress was used induce depression-like behaviors mice, assessed with behavioral tests. Glycogen concentration medial prefrontal cortex (mPFC) and expression key enzymes were investigated using Western blots, immunofluorescent staining, electron microscopy, biochemical assays. Stereotaxic surgery viral-mediated gene...
Reward system has been proved to be important nociceptive behavior, and the nucleus accumbens (NAc) is a key node in reward circuitry. It further revealed that dopamine modulates NAc influence pain sensation, whereas role of glutamatergic projection modulation chronic still elusive. In this study, we used complete Freund’s adjuvant-induced inflammatory model explore changes terminals NAc, found following inflammation, protein level vesicular glutamate transporter1 (VGLUT1) was significantly...
Although several studies have found that metabotropic glutamate 5 receptor (mGluR5) may play an important role in autism spectrum disorders (ASD), the mechanisms remain unclear. Here, we used a Shank3 gene complete knockout mouse model (Shank3B-/-) to explore change mGluR5 brain. To assess whether deletion of mice results ASD-like behavior, conducted battery behavioral experiments characterize Shank3B-/- mice, including repetitive grooming behavior tests, three-chamber tests and...
Abstract Despite remarkable progress in understanding the fundamental bases of itching, its cortical mechanisms remain poorly understood. Herein, causal contributions defined anterior cingulate cortex (ACC) neuronal populations to acute itch modulation mice are established. Using cell type‐specific manipulations, opposing functions ACC glutamatergic and GABAergic neurons regulating itching demonstrated. Photometry studies indicated that activated during scratching induced by both histamine...