A5101912553- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- Flowering Plant Growth and Cultivation
- Bariatric Surgery and Outcomes
- Stress Responses and Cortisol
- Anesthesia and Neurotoxicity Research
- Neurogenesis and neuroplasticity mechanisms
- Biochemical effects in animals
- Diet and metabolism studies
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Neurobiology and Insect Physiology Research
- Intensive Care Unit Cognitive Disorders
- Dermatology and Skin Diseases
- Diabetes Treatment and Management
- Anesthesia and Sedative Agents
- Cholesterol and Lipid Metabolism
- Tryptophan and brain disorders
- Genetic Neurodegenerative Diseases
- Ion Channels and Receptors
- Neuroendocrine regulation and behavior
- Retinal Development and Disorders
Air Force Medical University
2013-2025
Children's Hospital of Philadelphia
2025
University of Pennsylvania
2017-2025
Nova Southeastern University
2023
Chinese People's Liberation Army
2023
Chung Shan Medical University
2023
Guangzhou University of Chinese Medicine
2019
Army Medical University
2013-2018
National Institute of Dental and Craniofacial Research
2018
Xinqiao Hospital
2013-2018
The role of apoptosis in the pathogenesis intervertebral disc degeneration (IDD) remains enigmatic. Accumulating evidence has shown that apoptotic machinery is regulated by miRNAs. We hypothesized miRNAs might contribute to IDD. have found 29 were differentially expressed and miR-155 was down-regulated degenerative nucleus pulposus (NP). deregulation further verified using real-time PCR (0.56 fold, p < 0.05). Bioinformatics target prediction identified FADD caspase-3 as putative targets...
The dorsal medial prefrontal cortex (dmPFC) has been recognized as a key cortical area for nociceptive modulation. However, the underlying neural pathway and function of specific cell types remain largely unclear. Here, we show that lesions in dmPFC induced an algesic anxious state. Using multiple tracing methods including rabies-based transsynaptic method, outlined excitatory descending from to ventrolateral periaqueductal gray (vlPAG). Specific activation dmPFC/vlPAG by optogenetic...
Spinocerebellar ataxia (SCA) type 7 is an inherited neurodegenerative disorder caused by expansion of a polyglutamine tract within the ataxin-7 protein. To determine molecular basis neurotoxicity in this and other related disorders, we produced SCA7 transgenic mice that express with 24 or 92 glutamines all neurons CNS, except for Purkinje cells. Transgenic expressing (92Q) developed dramatic neurological phenotype presenting as gait culminating premature death. Despite absence expression...
Neutrophil infiltration has been linked to worse clinical outcomes after ischemic stroke. Microglia, a key type of immune-competent cell, engage in cross-talk with the infiltrating immune cells inflamed brain area, yet molecular mechanisms involved remain largely unexplored. In this study, we investigated how canonical transient receptor potential 1 (TRPC1) modulated neutrophil male mouse cerebral ischemia and reperfusion injury (CIRI) models. Our findings revealed notable upregulation TRPC1...
Microglial canonical transient receptor potential channel 1 (TRPC1) has been proposed to influence neuroinflammation after cerebral ischemia and reperfusion injury (CIRI), however, the underlying mechanism remains poorly understood. This study demonstrates that TRPC1 is modified by small ubiquitin-related modifier (SUMO)ylation. Our findings suggest a notable increase in microglial SUMOylation within both middle artery occlusion (MCAO/R) model vitro oxygen-glucose deprivation/regeneration...
Pulpitis is a common oral disease associated with severe pain, which often accompanied by sleep disturbances and anxiety-like symptoms. There currently no specific analgesic medication available to alleviate pulpitis-induced pain. In the current study, we applied transcriptomics conduct bioinformatics screening of trigeminal ganglion (TG) medullary dorsal horn (MDH) over 7-day period pulp exposure, aiming identify key differentially expressed genes (DEGs). We identified three DEGs in TG MDH,...
Variability in the interpretation of videourodynamics studies limits reliable classification kidney injury risk for patients with spina bifida. We developed machine learning models to predict incident hydronephrosis bifida using data. trained data from performed between 2016 and 2022 on aged 2 months 42 years. evaluated performance four following an index study: 1) random survival forest model prospectively abstracted by urologists, 2) bladder volume-pressure data, 3) utilizing deep features...
Pain and itch are intricately entangled at both circuitry behavioral levels. Emerging evidence indicates that parvalbumin (PV)-expressing neurons in zona incerta (ZI) critical for promoting nocifensive behaviors. However, the role of these modulation remains elusive. Herein, by combining FOS immunostaining, fiber photometry, chemogenetic manipulation, we reveal ZI PV act as an endogenous negative diencephalic modulator processing. Morphological data showed histamine chloroquine stimuli...
Paclitaxel is widely used as a first-line chemotherapy agent to treat malignant tumors. However, paclitaxel causes peripheral nerve fiber damage and neuropathic pain in some patients. In addition, patients received are often accompanied by negative emotions such anxiety. The amygdala critically involved regulating signals, well purpose of this study clarify the role Ca2+/calmodulin-dependent protein kinase II (CaMKII)-positive glutamatergic neurons paclitaxel-induced affective symptoms....
Mitochondria play an important role in pathophysiology of inflammatory and neuropathic pain but the mechanism is unclear. So far no comprehensive study exists that evaluates changes mitochondrial dynamics following pain. In this study, we detected distribution subcellular morphology by using intrathecal injection marker, Mitotracker Red® CM-H2XRox (Mito-Red) confocal microscopic analysis models formalin-induced acute pain, Complete Freund's Adjuvant (CFA)-induced persistent spared nerve...
Previous evidence has suggested that dietary supplementation with a bioactive polyphenol preparation (BDPP) rescues impairment of hippocampus-dependent memory in mouse model sleep deprivation (SD). In the current study, we extend our previous and demonstrate mechanism by which BDPP protects against SD-mediated cognitive is via mechanisms involve phosphorylation mammalian target rapamycin complex 1 its direct downstream targets, including eukaryotic translation initiation factor 4E...
Neutrophils plays a crucial role in acute ischemic brain injury and have emerged as potential treatment targets to mitigate such injuries. Lysine-specific demethylase 4 A (KDM4A), member of the histone lysine family enzymes involved transcriptional regulation gene expression, is upregulated during hypoxic events. However, exact KDM4A pathological process stroke remains largely unexplored. Our findings reveal that there was an upregulation levels reactive astrocytes within both mouse models...