A5057386480- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Amyotrophic Lateral Sclerosis Research
- Stress Responses and Cortisol
- T-cell and B-cell Immunology
- Neuroscience and Neuropharmacology Research
- Immunotherapy and Immune Responses
- Genetic Neurodegenerative Diseases
- Multiple Sclerosis Research Studies
- Mitochondrial Function and Pathology
- Gut microbiota and health
- Cholinesterase and Neurodegenerative Diseases
- Anesthesia and Neurotoxicity Research
- Photoreceptor and optogenetics research
- Biochemical Analysis and Sensing Techniques
- Macrophage Migration Inhibitory Factor
- Cholesterol and Lipid Metabolism
- Probiotics and Fermented Foods
- Cytomegalovirus and herpesvirus research
- Genetic and phenotypic traits in livestock
- Parkinson's Disease Mechanisms and Treatments
- Neurogenetic and Muscular Disorders Research
- Muscle Physiology and Disorders
- Peripheral Neuropathies and Disorders
The University of Texas Southwestern Medical Center
2023-2024
Icahn School of Medicine at Mount Sinai
2018-2023
Southwestern Medical Center
2023
The University of Texas at Dallas
2013-2015
Southern Methodist University
2015
DuPont (United States)
1986
Dietary polyphenols promote memory in models of sleep deprivation (SD), stress, and neurodegeneration. The biological properties dietary greatly depend upon the bioavailability their phenolic metabolites derivatives, which are modulated by gut microbiota. We recently demonstrated that supplementation with grape-derived bioactive polyphenol preparation (BDPP) improves SD-induced cognitive impairment. This study examined role microbiota ability BDPP to prevent impairment response SD. C57BL6/J...
Huntington9s disease (HD) is caused by a polyglutamine expansion within the huntingtin (Htt) protein. Both loss of function normal Htt and gain toxic polyglutamine-expanded mutant protein have been proposed to be responsible for HD, although molecular mechanisms involved are unclear. We show that neuroprotective in both HD-related unrelated model systems. Neuroprotection mediated its sequestration histone deacetylase-3 (HDAC3), known promote neuronal death. In contrast Htt, interacts poorly...
Abstract Sleep deprivation is a form of stress that provokes both inflammatory responses and neuropsychiatric disorders. Because persistent inflammation implicated as physiological process in anxiety disorders, we investigated the contributions NLRP3 inflammasome signaling to anxiolytic properties flavanol diets model chronic sleep deprivation. The results show flavanol-rich dietary preparation (FDP) exhibits by attenuating markers neuroimmune activation, which included IL-1β upregulation,...
Previous evidence has suggested that dietary supplementation with a bioactive polyphenol preparation (BDPP) rescues impairment of hippocampus-dependent memory in mouse model sleep deprivation (SD). In the current study, we extend our previous and demonstrate mechanism by which BDPP protects against SD-mediated cognitive is via mechanisms involve phosphorylation mammalian target rapamycin complex 1 its direct downstream targets, including eukaryotic translation initiation factor 4E...
Major depressive disorder (MDD) is a leading cause of disability, and there an urgent need for new therapeutics. Stress-mediated induction pro-inflammation in the periphery contributes to depression-like behaviors both humans experimental models. Inflammatory cytokine interleukin-6 (IL-6) has emerged as potential therapeutic target. Our studies demonstrated that metabolism flavanol rich cocoa preparation (FRP) led accumulation select phenolic acids may contribute its anti-inflammatory...
Grape-derived polyphenols have been investigated for their role in promoting memory model systems of stress, but little is known about select subpopulations neurons that are influenced by to improve performance. Granule the hippocampal dentate gyrus vulnerable stressors impair contextual function and can be dietary polyphenols. We utilized a c-fos-tTA/TRE-ChR2 optogenetics which activated during fear learning labeled with ChR2-mCherry optically reactivated different context recapitulate...
Abstract Background Pediatric acute transverse myelitis (ATM) accounts for 20–30% of children presenting with a first acquired demyelinating syndrome (ADS) and may be the clinical presentation relapsing ADS such as multiple sclerosis (MS). B cells have been strongly implicated in pathogenesis adult MS. However, little is known about pediatric MS, even less so ATM. Our lab previously showed that plasmablasts (PB), earliest cell subtype producing antibody, are expanded ATM, these PBs produce...
Multiple sclerosis is an inflammatory degenerative condition of the central nervous system that may result in debilitating disability. Several studies over past twenty years suggest multiple manifests with a rapid, more disabling disease course among individuals identifying Black or Latin American ethnicity relative to those White ethnicity. However, very little known about immunologic underpinnings contribute this ethnicity-associated discordant clinical severity. Given importance B cells...
Abstract The purpose of this study was to determine if inhibitors innate immunity in microglia could attenuate sleep deprivation (SD)-induced psychological impairment, which involve the assembly and activation NLRP3 inflammasome. In study, CD-1 mice were immune-primed with chronic corticosterone treatment (20 mg/kg IP) for two weeks subsequently subjected one bout 6 hr SD. Mice sacrificed immediately afterward measure cytokine concentrations caspase-1 activity. We found a significant...
Abstract Intronic G 4 C 2 hexanucleotide repeat expansions (HRE) of C9orf72 are the most common cause familial variants frontotemporal dementia/amyotrophic lateral sclerosis (FTD/ALS). HREs in undergo non-canonical repeat-associated translation, producing dipeptide (DPR) proteins, with various deleterious impacts on cellular homeostasis. While five different DPRs produced, poly(glycine-arginine) (GR) is amongst toxic and only DPR to accumulate associated clinically relevant anatomical...
Abstract Pediatric and adult autoimmune encephalitis (AE) are often associated with Abs to the NR1 subunit of N-methyl-d-aspartate (NMDA) receptor (NMDAR). Very little is known regarding cerebrospinal fluid humoral immune profile Ab genetics pediatric anti–NMDAR-AE. Using a combination cellular, molecular, immunogenetics tools, we collected from subjects generated 1) flow cytometry data calculate frequency B cell subtypes in anti–NMDAR-AE controls, 2) panel recombinant human case that was...
Abstract Background Alzheimer’s disease (AD) is a multifaceted disorder and recent advancements suggest that the gut microbiota its metabolites play critical role in progression potential treatment of AD. Synbiotics, combination probiotics prebiotics, can be designed to produce specific bioavailable penetrate blood‐brain‐barrier actively reduce neuropathologies associated with Recently, we an vitro model human gastrointestinal tract used optimize production from synbiotic formulations using...
Abstract Background Familial frontotemporal dementia (FTD) has been associated with mutations in the G 4 C 2 promoter of C9orf72 leading to production dipeptide protein repeats (DPRs), most neurotoxic being Glycine‐Arginine (GR). Previous studies have found a parallel relationship accumulation DPRs and neuroinflammatory response. Specifically, determined microglia proliferation persistent activation plays role disease progression neurodegeneration. The current study investigated effect...
Abstract Background Frontotemporal dementia (FTD) is a neurodegenerative disorder with various genetic etiologies, the most prevalent of which include G 4 C 2 expansions in c9orf72 gene. Expansions produce dipeptide repeat proteins (DPR), forming aggregates deleterious impacts on cellular processes and correlating neuroinflammation. Glycine‐Arginine (GR) are only significantly correlated DPR found clinically relevant neuroanatomical regions brain. Our current study investigates contribution...
Abstract Intronic G 4 C 2 hexanucleotide repeat expansions (HRE) of C9orf72 are the most common cause familial variants frontotemporal dementia/amyotrophic lateral sclerosis (FTD/ALS). HREs in undergo non-canonical repeat-associated translation, producing dipeptide (DPR) proteins, with various deleterious impacts on cellular homeostasis. While five different DPRs produced, poly(glycine-arginine) (GR) is amongst toxic and only DPR to accumulate associated clinically relevant anatomical...