A5101862731- Prenatal Substance Exposure Effects
- Birth, Development, and Health
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Neonatal and fetal brain pathology
- Neuroscience and Neuropharmacology Research
- Amyotrophic Lateral Sclerosis Research
- Immunotherapy and Immune Responses
- Stress Responses and Cortisol
- Glioma Diagnosis and Treatment
- Bacteriophages and microbial interactions
- CNS Lymphoma Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Urological Disorders and Treatments
- Ultrasound and Hyperthermia Applications
- SARS-CoV-2 and COVID-19 Research
- MicroRNA in disease regulation
- CAR-T cell therapy research
- Groundwater flow and contamination studies
- Ureteral procedures and complications
- Alcohol Consumption and Health Effects
- Nanoparticle-Based Drug Delivery
- Cholinesterase and Neurodegenerative Diseases
- Immune cells in cancer
- Psychosomatic Disorders and Their Treatments
Lallemand (Canada)
2024
PerkinElmer Biosignal
2024
National Research Council Canada
2020-2024
University of Agriculture Faisalabad
2023
Icahn School of Medicine at Mount Sinai
2020-2023
University of Florida
2021
Farooq Hospital
2020
National Academies of Sciences, Engineering, and Medicine
2013
University of Ottawa
2010
Institute for Biological Sciences
2010
Chimeric antigen receptor (CAR-) T cell therapies targeting B-cell restricted antigens CD19, CD20, or CD22 can produce potent clinical responses for some malignancies, but relapse remains common. Camelid single domain antibodies (sdAbs nanobodies) are smaller, simpler, and easier to recombine than single-chain variable fragments (scFvs) used in most CARs, fewer sdAb-CARs have been reported. Thus, we sought identify a therapeutically active sdAb-CAR human CD22. Immunization of an adult Llama...
Abstract When utilized in therapeutic applications, synthetic self-amplifying RNA (saRNA) can lead to higher and more sustained expression than standard messenger (mRNA). This feature is particularly important for gene replacement therapy applications where prolonged could reduce the dose frequency of treatments. The inclusion modified nucleotides non-amplifying mRNA has been shown increase stability, immune activation enhance expression. Preclinical clinical studies with saRNA have so far...
Focusing on the Lower Bari Doab Canal (LBDC) command area, characterized by its heavy reliance agriculture, this study addresses critical issue of groundwater table fluctuations in response to diverse pumping scenarios. Herein, we comprehensively evaluated dynamic interplay between crop water requirements and within expansive canvas LBDC, which is facing shortages. Using Penman–Monteith equation, calculated annual average evapotranspiration for major crops—wheat, maize, cotton, rice,...
Archaeosomes are liposomes formulated using total polar lipids (TPLs) or semi-synthetic glycolipids derived from archaea. Conventional archaeosomes with entrapped antigen exhibit robust adjuvant activity as demonstrated by increased antigen-specific humoral and cell-mediated responses enhanced protective immunity in various murine infection cancer models. However, entrapment efficiency can vary greatly resulting loss during formulation variable antigen:lipid ratios. In order to circumvent...
Exposure to high cortisol concentration can injure the developing brain, possibly via an excitotoxic mechanism involving glutamate (Glu). The present study tested hypothesis that chronic prenatal ethanol exposure (CPEE) activates foetal hypothalamic-pituitary-adrenal axis produce in compartment and alters sensitivity glucocorticoid-induced Glu release hippocampus. Pregnant guinea pigs received daily oral administration of (4 g/kg maternal body weight/day) or isocaloric-sucrose/pair-feeding...
Abstract Background Standard MRI has been used for high-grade gliomas detection, albeit with limited success as it does not provide sufficient specificity and sensitivity to detect complex tumor structure. Therefore targeted contrast agents based on iron oxide, that shorten mostly T2 relaxation time, have recently applied. However pulse sequences molecular imaging in animal models of yet fully studied. The aim this study was therefore compare contrast-to-noise ratio (CNR) explain its origin...
Archaeosomes, composed of sulfated lactosyl archaeol (SLA) glycolipids, have been proven to be an effective vaccine adjuvant in multiple preclinical models infectious disease or cancer. They classically prepared using a thin-film hydration method with average particle size 100-200 nm. In this study, we developed methods generate SLA archaeosomes at different sizes, i.e., 30 nm and 100 nm, via microfluidic mixing technology evaluated their physicochemical characteristics, as well activity...
The prevalence of depression significantly increases during puberty and adolescence. Puberty is the period which sexual maturity attained, while adolescence persists beyond includes physiological, social, emotional, cognitive maturation. A stressor that has been shown previously to induce chronic sleep disruption. Probiotics can prevent stress-induced depression. However, it was unclear whether probiotics could following disruption what mechanism may be involved. Therefore, we investigated...
Background: The superfamily of glutamate‐gated ion channels mediates fast excitatory synaptic transmission in the central nervous system and is composed NMDA, AMPA, kainate receptors. Binding studies have shown that chronic prenatal and/or neonatal ethanol exposure produces persistent effects on numbers some these channels. However, whether or not this long‐lasting expression specific ionotropic receptor subunits remains an open question. Methods: Timed pregnant Dunkin‐Hartley strain guinea...
The superfamily of glutamate-gated ion channels mediates fast excitatory synaptic transmission in the central nervous system and is composed NMDA, AMPA, kainate receptors. Binding studies have shown that chronic prenatal and/or neonatal ethanol exposure produces persistent effects on numbers some these channels. However, whether or not this long-lasting expression specific ionotropic receptor subunits remains an open question.Timed pregnant Dunkin-Hartley strain guinea pigs received oral...
SARS-CoV-2 the causative agent of COVID-19 displays a broad range pathophysiology. Cytokine storms associated with damage blood-brain barrier (BBB) and allow pro-inflammatory factors to invade brain, further promoting neurodegeneration. While viral RNA proteins have been detected in brain tissues, mechanisms neuroinvasion remain unknown. has had disproportionate impact on those suffering from neurodegenerative disorders such as Alzheimer's disease (AD). Understanding is crucial study...
This study intended to explore the effect of T regulatory cells (Tregs) in perinatal liver against LPS-induced inflammation a preterm birth mouse model. Moreover, role adoptive Tregs on inflammatory response induced by LPS was also studied.Female BALB/C mice were injected intraperitoneally (IP) with dissolved normal saline solution at dose 50 µg/kg. Spleens from pregnant used obtain Tregs. The expression Forkhead family transcription factor-3 (Foxp3), Interleukin-6 (IL-6), Toll-like...
Abstract Intronic G 4 C 2 hexanucleotide repeat expansions (HRE) of C9orf72 are the most common cause familial variants frontotemporal dementia/amyotrophic lateral sclerosis (FTD/ALS). HREs in undergo non-canonical repeat-associated translation, producing dipeptide (DPR) proteins, with various deleterious impacts on cellular homeostasis. While five different DPRs produced, poly(glycine-arginine) (GR) is amongst toxic and only DPR to accumulate associated clinically relevant anatomical...
You have accessJournal of UrologyBladder Cancer: Invasive V (PD59)1 Sep 2021PD59-11 URETERO-ENTERIC STRICTURES AFTER ROBOT ASSISTED RADICAL CYSTECTOMY: PREVALENCE AND PREDICTORS Umar Iqbal, Holly Houenstein, Zhe Jing, Nighat Sofi, Gaybrielle James, Ahmed S. Elsayed, Qiang Li, A. Hussein, and Khurshid Guru Iqbal More articles by this author , HouensteinHolly Houenstein JingZhe Jing SofiNighat Sofi JamesGaybrielle James ElsayedAhmed Elsayed LiQiang Li HusseinAhmed Hussein GuruKhurshid View All...
The most common monogenic cause of frontotemporal dementia and amyotrophic lateral sclerosis (FTD/ALS) are G4 C2 repeat expansions in the c9orf72 gene. Aggregations dipeptide proteins (DPR) produced by these have toxic effects on cellular homeostasis, coinciding with neuroinflammation cell death. Glycine-Arginine (GR) aggregates significantly present regions brain impacted FTD/ALS. Here, we demonstrate causal role microglia mediated innate immune responses pathogenesis FTD/ALS identify NLRP3...