A5100412745- Ferroptosis and cancer prognosis
- Neonatal Respiratory Health Research
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Congenital Diaphragmatic Hernia Studies
- RNA modifications and cancer
- Pregnancy and preeclampsia studies
- MicroRNA in disease regulation
- Birth, Development, and Health
- Reproductive System and Pregnancy
- Epigenetics and DNA Methylation
- Anesthesia and Neurotoxicity Research
- Cancer, Lipids, and Metabolism
- Preterm Birth and Chorioamnionitis
- Neuroscience of respiration and sleep
- Infant Development and Preterm Care
- Long-Term Effects of COVID-19
- Inflammasome and immune disorders
- Immune Response and Inflammation
- RNA Interference and Gene Delivery
- Bladder and Urothelial Cancer Treatments
- Tryptophan and brain disorders
- RNA Research and Splicing
- Tracheal and airway disorders
Chongqing Medical University
2024
Northwest A&F University
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
First Affiliated Hospital of Xi'an Jiaotong University
2016-2023
Burning Rock Biotech (China)
2023
Background: Immune checkpoint inhibitors (ICIs) have shown efficacy in patients with metastatic urothelial cancer (mUC), however, only a small subset of could benefit from ICIs. Identifying predictive biomarkers ICIs mUC is clinical meaningful for patient stratification and administration. Methods: Clinical transcriptomic data treated cohort (IMvigor210 study) was utilized to explore the biomarkers. LASSO Cox regression performed construct model. The model trained tested cohort, then...
We previously demonstrated that a transforming growth factor β type II receptor (TGFBR2) mutation can predict resistance to immune checkpoint inhibitors (ICIs) in patients with advanced non-small cell lung cancer (NSCLC), based on publicly available immunotherapeutic cohorts. However, the efficacy of ICI-based regimens NSCLC harboring TGFBR2 mutations real-world setting is rarely reported. The present study describes case patient who harbors mutation. was treated ICI monotherapy and...
Hepatocellular carcinoma (HCC) is one of the most invasive cancers with a low 5-year survival rate. Pyroptosis, specialized form cell death, has shown its association cancer progression. However, role in prognosis HCC not been fully understood.In our study, clinical information and mRNA expression for 1076 patients were obtained from five public cohorts. Pyroptotic clusters generated by unsupervised clustering based on 40 pyroptosis-related genes (PRGs) TCGA ICGC cohort. A signature was...
To evaluate the effect of regulatory T cells (Tregs) on inflammation resulting from lipopolysaccharide (LPS) challenge in prenatal brain tissue, Tregs isolated pregnant mice were transferred into model mice, and expression levels fork head family transcription factor (Foxp3), interleukin-6 (IL-6), CD68 (a marker microglia), toll-like receptor 4 (TLR-4) assessed fetal tissue. Foxp3, IL-6, TLR-4 detected by polymerase chain reaction Western blot; level was using immunochemical analysis. TLR-4,...
A thorough assessment of lactate-related genes (LRGs) in different types human cancers is currently lacking. To elucidate the molecular landscape LRGs, we conducted a comprehensive analysis using genomic, mRNA, and microRNA expression profiles developed lactate score model least absolute shrinkage selection operator (LASSO) algorithm. We found that our could be prognostic marker instead LDHA for several cancer patients who possess high-frequency variants LRGs. The also demonstrated an...
Esophageal atresia (EA) is a life-threatening congenital malformation in newborns, and the traditional repair approaches pose technical challenges are extremely invasive. Therefore, surgeons have been actively investigating new minimally invasive techniques to address this issue. Magnetic compression anastomosis has reported several studies for its potential repairing EA. In paper, primary of EA with magnetic under thoracoscopy was reported.
Abstract Background Home oxygen therapy (HOT) is indicated upon discharge in some preterm infants with severe bronchopulmonary dysplasia (BPD). There a lack of evidence-based consensus on the indication for HOT among these infants. Because wide variation institutional use exists, little known about role regional social-economic level HOT. Methods This was secondary analysis Chinese Neonatal Network (CHNN) data from January 1, 2019 to December 31, 2019. Infants at gestational ages < 32...
This study intended to explore the effect of T regulatory cells (Tregs) in perinatal liver against LPS-induced inflammation a preterm birth mouse model. Moreover, role adoptive Tregs on inflammatory response induced by LPS was also studied.Female BALB/C mice were injected intraperitoneally (IP) with dissolved normal saline solution at dose 50 µg/kg. Spleens from pregnant used obtain Tregs. The expression Forkhead family transcription factor-3 (Foxp3), Interleukin-6 (IL-6), Toll-like...