A5063759157- Birth, Development, and Health
- Neonatal Respiratory Health Research
- Infant Nutrition and Health
- Metabolism and Genetic Disorders
- Pregnancy and preeclampsia studies
- Infant Development and Preterm Care
- Congenital Diaphragmatic Hernia Studies
- Cytomegalovirus and herpesvirus research
- Neonatal and fetal brain pathology
- Neonatal and Maternal Infections
- Sepsis Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Streptococcal Infections and Treatments
- Adipose Tissue and Metabolism
- Neuroscience of respiration and sleep
- Liver Disease Diagnosis and Treatment
- Renal and related cancers
- Fatty Acid Research and Health
- Diet and metabolism studies
- Growth Hormone and Insulin-like Growth Factors
- Respiratory Support and Mechanisms
- Preterm Birth and Chorioamnionitis
- Bone Metabolism and Diseases
- COVID-19 Impact on Reproduction
- MicroRNA in disease regulation
Second Xiangya Hospital of Central South University
2015-2024
Central South University
2015-2024
Shanghai Children's Medical Center
2023
Shanghai Jiao Tong University
2023
Children's Hospital of Fudan University
2022
Network Group (Czechia)
2021
<h3>Importance</h3> The Chinese Neonatal Network was established in 2018 and maintains a standardized national clinical database of very preterm or low-birth-weight infants tertiary neonatal intensive care units (NICUs) throughout China. National-level data on outcomes practices (VPIs) China are lacking. <h3>Objective</h3> To assess the NICUs among VPIs <h3>Design, Setting, Participants</h3> A cohort study conducted comprising 57 hospitals from 25 provinces All with gestational age (GA) less...
Metabolic bone disease of prematurity (MBDP) is a systemic with reduction in mineral content due to disorder calcium and phosphorus metabolism. There still lack in-depth research systematic understanding MBDP China, there are many irregularities clinical management this disease. Based on relevant studies China overseas, Grading Recommendations Assessment, Development Evaluation was used develop the expert consensus MBDP, which provides recommendations from following five aspects: high-risk...
Abstract Background Caffeine citrate is used to prevent apnea in premature infants and help extubation of invasive ventilation, but the optimal dose remains undetermined. Methods Neonates born at less than 30 weeks gestation who had received ventilation for least 48 hours a loading 20 mg/kg caffeine were randomly assigned into high (10 daily) or low (5 maintenance groups. The drug was discontinued if no occurred 7 consecutive days. Results A total 111 (54) (57) Extubation failure (16.7% vs...
Intrauterine growth restriction is a condition that prevents normal fetal development, and previous studies have reported intrauterine caused by adverse factors. This affects both short- long-term neurodevelopmental disorders. Studies revealed disorders can contribute to gray white matter damage decrease the brain volume of affected individuals. Further, these are associated with increased risks mental retardation, cognitive impairment, cerebral palsy, which seriously affect quality life....
In humans, malnutrition during pregnancy results in intrauterine growth restriction (IUGR) and an increased risk of neurological morbidities; altered miRNA characteristics have been suggested to contribute IUGR pathogenesis. A microarray was used identify differentially expressed molecules the hippocampi rats with IUGR. Five question were selectively validated using real-time PCR We then investigated role miR-199a-5p hippocampal pathology. Bioinformatics analysis that TNF-α, caspase-3 SIRT1...
Abstract Objective We aimed to assess whether serum 25‐hydroxyvitamin D (25(OH)D) levels at birth are associated with pulmonary disease morbidities in very preterm infants. Methods This prospective cohort analysis included 93 infants born before 32 weeks of gestation the Second Xiangya Hospital Central South University between March 2016 and February 2017. Participants were classified into three groups according their 25(OH)D birth. The compared terms demographic variables morbidities....
<b><i>Background/Aims: </i></b>The objective of this study was to examine the responses p53 promoter methylation involved in kidney structure and function early weaning intrauterine growth retarded (IUGR) rats dietary folic acid supplementation. <b><i>Method: </i></b>Sprague-Dawley were fed isocaloric diets containing either 21% protein diet (normal feed) or 10% throughout pregnancy normal feed during lactation. After weaning, Offspring then...
Epidemiological studies have shown that low birth weight (LBW) is associated with a higher incidence of hypertension in adulthood. LBW may affect the kidney development, which turn leads to impaired renal function and hypertension.Sprague-Dawley rats were fed isocaloric diets containing either 21% (w/w) (control group) or 10% (LBW protein throughout pregnancy chow during lactation. Renal structure offspring measured from 3 months.At weeks 2 months, there was no difference volume 24 h urine...
Aim: This study investigated the mechanisms involved in intrauterine growth restriction (IUGR). Methods: The IUGR model was established by feeding pregnant SD rats a low-protein diet. Protein expression and phosphorylation were detected using Western blot and/or immunohistochemistry. Cell apoptosis TUNEL staining. MDM2 mRNA measured real-time PCR. Results: Pups from group had significantly lower body (7th day, 2 months) kidney weights (1st 7th compared to pups control (p < 0.01). glomeruli...
Intrauterine growth restriction (IUGR) is defined as the failure of a fetus to reach its genetic potential in utero resulted by maternal, placental, fetal, and factors. Previous studies have reported that IUGR associated with high incidence neurological damage, although precise causes such damage remain unclear. We aimed investigate whether cognitive impairment rats related pyroptosis hippocampal neurons determine effect early intervention docosahexaenoic acid (DHA).Learning memory function...
The present study aimed to investigate the response of phosphatidylinositol 3-kinase (PI3K) signaling pathway and gluconeogenic enzymes in intrauterine growth-restricted rats dietary L-arginine (L-Arg) supplementation during lactation period early life. Pregnant Sprague-Dawley were randomly divided into a control group (CON), an growth restriction (IUGR) L-Arg (LA). pregnant CON fed 21% protein diet, those IUGR LA groups 10% low all diet after delivery. Water was available ad libitum 21-day...
Intrauterine growth retardation (IUGR) can affect kidney development, leading to reduction in glomerular number. However, the associated cellular and molecular mechanisms have not been fully elucidated. This study investigated cell apoptosis Bcl-2 Bax expression of IUGR pups.The model was established pregnant rats with 10% low-protein diet. Renal detected using TUNEL staining. Ki67 protein measured by immunohistochemistry. mRNA real-time polymerase chain reaction (PCR).Significant decreases...
To investigate serum bone biomarkers in rats with intrauterine growth restriction (IUGR) order to determine the effects of puerarin on metabolism. A rat model IUGR was induced using a low protein diet during pregnancy. The offspring were given or an identical volume saline via subcutaneous abdominal injection. All studied at 1,3, and 8 weeks age. Serum formation, including insulin-like factor-1 (IGF-1), bone-specific alkaline phosphatase (BALP), osteocalcin (OC), osteoprotegerin (OPG),...
The prevalence of preterm birth has been rising, and there is a paucity nationwide data on the perinatal characteristics neonatal outcomes twin deliveries very infants (VPIs) in China. This study compared singletons twins admitted to intensive care units (NICUs) China.The population comprised all born before 32 weeks Chinese Neonatal Network (CHNN) between January 2019 December 2019. Three-level population-average generalized estimating equation (GEE)/alternating logistic regression (ALR)...
With the development of perinatal and neonatal intensive care medicine, survival rate very premature infants increases year by year. However, incidence bronchopulmonary dysplasia (BPD) year, which seriously affects prognosis infants. How to prevent treat BPD effectively has become focus neonatologists. This study aims provide ideas for prevention treatment in preterm via analyzing clinical characteristics BPD.
Intrauterine growth retardation (IUGR) impairs immune function in children. IUGR is associated with an imbalance of oxidative stress and abnormal apoptosis. Therefore, rats model was established to determine the antioxidant capacity apoptosis newborn explored whether these effects were regulated after Docosahexaenoic acid (DHA) supplementation rat pups. First, eight normal-birth-weight (NBW) neonatal (a 10% low-protein diet) used obtain Then, 32 randomly assigned normal birth weight (NBW),...
To investigate the expression of gluconeogenic enzymes phosphoenolpyruvate carboxykinase (PEPCK) and G-6-Pase mRNA hepatic tissue in rats with intrauterine growth retardation (IUGR) to explore molecular mechanism insulin resistance IUGR rats.Pregnant were randomly divided into 2 groups: a normal group model group. The fed 21% protein forage 10% low obtain pup rats. introduced prospectively. At 1, 3 8 weeks, body weight, blood glucose, concentration index measured. Expression PEPCK detected...
Neonatal sepsis, as a significant cause of various complications and adverse outcomes in neonates, remains serious health burden both domestically internationally. Strategies such antibiotic prophylaxis during delivery, the utilization early-onset sepsis risk calculators, quality improvement initiatives neonatal wards are beneficial alleviating disease sepsis. This paper provides review epidemiology, factors, recent advances clinical management