A5104283896- CRISPR and Genetic Engineering
- Genomics and Phylogenetic Studies
- Microbial Metabolic Engineering and Bioproduction
- Plant tissue culture and regeneration
- Silk-based biomaterials and applications
- Microbial Community Ecology and Physiology
- Weed Control and Herbicide Applications
- Legume Nitrogen Fixing Symbiosis
- Protein Interaction Studies and Fluorescence Analysis
- Bacterial Genetics and Biotechnology
- RNA and protein synthesis mechanisms
- Microbial Fuel Cells and Bioremediation
- Plant nutrient uptake and metabolism
- Wastewater Treatment and Nitrogen Removal
- Insect Resistance and Genetics
- Microbial bioremediation and biosurfactants
- Photosynthetic Processes and Mechanisms
- Invertebrate Immune Response Mechanisms
- COVID-19 Clinical Research Studies
- MicroRNA in disease regulation
- Plant Virus Research Studies
- Pesticide and Herbicide Environmental Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Plant-Microbe Interactions and Immunity
- Silkworms and Sericulture Research
Southwest University
2005-2025
Nanjing University of Chinese Medicine
2024-2025
Harbin Engineering University
2025
Zhejiang University
2005-2024
Shaanxi Normal University
2019-2024
Tiangong University
2024
Nanjing University of Science and Technology
2024
Shandong University
2024
Sir Run Run Shaw Hospital
2024
Hangzhou Normal University
2022-2024
Since December 2019, COVID-19 has occurred unexpectedly and emerged as a health problem worldwide. Despite the rapidly increasing number of cases in subsequent weeks, clinical characteristics pediatric are rarely described. A cross-sectional multicenter study was carried out 10 hospitals across Hubei province. total 25 confirmed were collected. The demographic data, epidemiological history, underlying diseases, manifestations, laboratory radiological treatments, outcomes analyzed. Of...
The capacity to fix nitrogen is widely distributed in phyla of Bacteria and Archaea but has long been considered be absent from the Pseudomonas genus. We report here complete genome sequencing nitrogen-fixing root-associated stutzeri A1501. consists a single circular chromosome with 4,567,418 bp. Comparative genomics revealed that, among 4,146 protein-encoding genes, 1,977 have orthologs each five other representative species sequenced date. contains genes involved broad utilization carbon...
CRISPR/Cas9, a bacterial adaptive immune system derived genome-editing technique, has become to be one of the most compelling topics in biotechnology. Bombyx mori is an economically important insect and model organism for studying lepidopteran arthropod biology. Here we reported highly efficient multiplex genome editing B. cell line heritable site-directed mutagenesis Bmku70, which required NHEJ pathway also related antigen diversity, telomere length maintenance subtelomeric gene silencing,...
The Hierarchical Taxonomy of Psychopathology (HiTOP) uses factor analysis to group people with similar self-reported symptoms (i.e., like-goes-with-like). It is hailed as a significant improvement over other diagnostic taxonomies. However, the purported advantages and fundamental assumptions HiTOP have received little, if any scientific scrutiny. We critically evaluated five claims about HiTOP. conclude that does not demonstrate high degree verisimilitude has potential hinder progress on...
Background Globally, about 20% of cultivated land is now affected by salinity. Salt tolerance a trait importance to all crops in saline soils. Previous efforts improve salt crop plants have met with only limited success. Bacteria the genus Deinococcus are known for their ability survive highly stressful conditions, and therefore possess unique pool genes conferring extreme resistance. In radiodurans, irrE gene encodes global regulator responsible radioresistance. Methodology/Principal...
Abstract Background Biological nitrogen fixation is highly controlled at the transcriptional level by regulatory networks that respond to availability of fixed nitrogen. In many diazotrophs, addition excess ammonium in growth medium results immediate repression nif gene transcription. Although cascades control transcription genes proteobacteria have been well investigated, there are limited data on kinetics ammonium-dependent fixation. Results Here we report a global profiling analysis and...
The desert is an excellent model for studying evolution under extreme environments. We present here the complete genome and ultraviolet (UV) radiation-induced transcriptome of Deinococcus gobiensis I-0, which was isolated from cold Gobi shows higher tolerance to gamma radiation UV light than all other known microorganisms. Nearly half genes in encode proteins unknown function, suggesting that resistance phenotype may be attributed pathways. D. also contains a surprisingly large number...
A key enzyme in the shikimate pathway, 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) is primary target of broad-spectrum herbicide glyphosate. Identification new aroA genes coding for EPSPS with a high level glyphosate tolerance essential development glyphosate-tolerant crops. In present study, five bacterial was evaluated E. coli aroA-defective strain ER2799 and transgenic tobacco plants. All could complement ER2799, AM79 showed highest tolerance. Although treatment inhibited growth...
Evolution has produced some remarkable creatures, of which silk gland is a fascinating organ that exists in variety insects and almost half the 34,000 spider species. The impressive ability to secrete huge amount pure protein, store proteins at an extremely high concentration (up 25%) make Bombyx mori hold great promise be cost-effective platform for production recombinant proteins. However, low yields numerous reported expression systems greatly hindered exploration application bioreactors....
Unlike most Pseudomonas, the root-associated bacterium Pseudomonas stutzeri A1501 fixes nitrogen after horizontal acquisition of a nitrogen-fixing (nif) island. A genome-wide search for small noncoding RNAs (ncRNAs) in P. identified novel stutzeri-specific ncRNA NfiS core genome, whose synthesis was significantly induced under fixation or sorbitol stress conditions. The expression RNA chaperone Hfq-dependent and activated by sigma factor RpoN/global activator NtrC/nif-specific NifA...
ABSTRACT Diabetes mellitus (DM) is an important factor in intervertebral disc degeneration (IDD). Apoptosis of cartilage endplate (CEP) cells one the initiators IDD. However, effects high glucose on CEP are still unknown. Therefore, we conducted present study to evaluate and identify mechanisms those effects. Rat were isolated cultured 10% foetal bovine serum (FBS, normal control) or high‐glucose medium (10% FBS + 0.1 M 0.2 glucose, experimental conditions) for 1 3 days. In addition, treated...
In their response to our article (both in this issue), DeYoung and colleagues did not sufficiently address three fundamental flaws with the Hierarchical Taxonomy of Psychopathology (HiTOP). First, HiTOP was created using a simple-structure factor-analytic approach, which does adequately represent dimensional space symptoms psychopathology. Consequently, is empirical structure Second, factor analysis ratings do fix problems inherent descriptive (folk) classification; self-reported are still...
As a central hub for metabolism, the liver exhibits strong adaptability to maintain homeostasis in response food fluctuations throughout evolution. However, mechanisms governing this resilience remain incompletely understood. In study, we identified Receptor interacting protein kinase 1 (RIPK1) hepatocytes as critical regulator preserving hepatic during metabolic challenges, such short-term fasting or high-fat dieting. Our results demonstrated that hepatocyte-specific deficiency of RIPK1...
As a central hub for metabolism, the liver exhibits strong adaptability to maintain homeostasis in response food fluctuations throughout evolution. However, mechanisms governing this resilience remain incompletely understood. In study, we identified Receptor interacting protein kinase 1 (RIPK1) hepatocytes as critical regulator preserving hepatic during metabolic challenges, such short-term fasting or high-fat dieting. Our results demonstrated that hepatocyte-specific deficiency of RIPK1...