A5102862041- Liver Disease Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Circular RNAs in diseases
- Spine and Intervertebral Disc Pathology
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Osteoarthritis Treatment and Mechanisms
- Diet, Metabolism, and Disease
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Vitamin C and Antioxidants Research
- Colorectal Cancer Surgical Treatments
- Cancer, Hypoxia, and Metabolism
- Neurogenesis and neuroplasticity mechanisms
- Extracellular vesicles in disease
- Diet and metabolism studies
- Folate and B Vitamins Research
- Alcohol Consumption and Health Effects
- Hepatitis B Virus Studies
- Nerve injury and regeneration
- Hepatitis C virus research
- Colorectal and Anal Carcinomas
- Nanoparticle-Based Drug Delivery
State Key Laboratory of Biotherapy
2022-2025
West China Hospital of Sichuan University
2022-2025
Sichuan University
2022-2025
Meizhou City People's Hospital
2024
West China Second University Hospital of Sichuan University
2024
Peking University Shougang Hospital
2017-2023
Jinshan Hospital of Fudan University
2014-2023
Soochow University
2022
King University
2022
Peking University
2015-2022
Background: Cancer stem cells (CSCs) possess the characteristics associated with normal and are responsible for cancer initiation, recurrence, metastasis. CD133 is regarded as a CSCs marker of osteosarcoma, which most common primary bone malignancy in childhood adolescence. Salinomycin, polyether ionophore antibiotic, has been shown to kill various CSCs, including osteosarcoma CSCs. However, salinomycin displayed poor aqueous solubility that hinders its clinical application. The objective...
ABSTRACT Diabetes mellitus (DM) is an important factor in intervertebral disc degeneration (IDD). Apoptosis of cartilage endplate (CEP) cells one the initiators IDD. However, effects high glucose on CEP are still unknown. Therefore, we conducted present study to evaluate and identify mechanisms those effects. Rat were isolated cultured 10% foetal bovine serum (FBS, normal control) or high‐glucose medium (10% FBS + 0.1 M 0.2 glucose, experimental conditions) for 1 3 days. In addition, treated...
Abstract Background Patients with nonalcoholic fatty liver disease (NAFLD) are reported to have a higher risk of osteoporosis/fractures; however, the causal relationship remains unclear. Methods Publicly available genome‐wide association studies (GWASs) were used for Mendelian randomization (MR) analysis. GWASs NAFLD and fractures obtained from FinnGen Consortium. bone mineral density (BMD) derived meta‐analysis. obesity, diabetes, function, serum lipid‐related metrics clarify whether...
There's a scarcity of drugs effective against nonalcoholic steatohepatitis (NASH). Exosomes from Human umbilical cord mesenchymal stem cells (huc-MSCs) show potential in managing glycolipid metabolism and the immune response. Therefore, further investigations are required to explore their application NASH underlying mechanisms. C57BL/6J mice were fed with western diet for 12 weeks induce NASH, huc-MSCs exosomes (MSCs-exo) administered during feeding period. The effect MSCs-exo was evaluated...
Osteoarthritis (OA) is a common degenerative joint disease. Effective drugs that can halt or decelerate osteoarthritis progression are still lacking. Omaveloxolone semisynthetic oleanane triterpenoid exerting antioxidative and anti-inflammatory effects. The present study aims to determine whether omaveloxolone has therapeutic effect on OA. Chondrocytes were treated with interleukin (IL)-1β establish an OA cell model in vitro. Indicators of viability, oxidative stress, inflammation, apoptosis...
Colorectal cancer (CRC) caused more than 65,000 mortalities worldwide per year. It is a result of one or combination chromosomal instability, CpG island methylator phenotype, and microsatellite instability. SNRPA1 (small nuclear ribonucleoprotein polypeptide A) subunit spliceosome complex that involved in the RNA processing. Overexpression has been implicated variety cancers including CRC. Besides from its role mediating processing, other aspects regarding function progression colorectal...
Epidemiological studies support the association between inadequate vitamin C (Vc) intake and non-alcoholic fatty liver disease (NAFLD). However, intervention dose of Vc, prophylactic therapeutic effects on NAFLD are unclear. This study aimed to investigate low (LVc), medium (MVc) high (HVc) doses Vc NAFLD. C57BL/6 mice were randomly assigned groups (mice received a high-fat diet (HFD) concomitant with different Vc) (HFD-induced treated Vc). Results showed that LVc MVc administration reduced...
Abstract Objective The aim of the study is to evaluate impact application surgical strategies at different cancer stages on survival gallbladder (GBC) patients. Methods patients with GBC were divided into 3 groups according their received strategies: simple resection (full-thickness cholecystectomy for removal primary tumor site), radical (gallbladder bed combined partial hepatectomy), and palliative surgery (treatment advanced stages). overall (OS) who was compared. Results Survival...
Exosome-mediated microRNAs (miRNAs) are closely related to the occurrence, development, invasion, metastasis, therapeutic resistance, diagnosis and treatment of malignant tumors.Guide-strand miRNA passenger-strand (miRNA*) exist in processing, but function is often overlooked.In this study, we attempted identify functional miRNA*s exosomes derived from human colon cancer SW620 cells.miRNA expression profiles normal colonic epithelial cells NCM460 were compared by high-throughput...
The purpose of this study is to compare and evaluate the security efficacy 3D vs 2D laparoscopy in rectal cancer treatment. Forty-six patients who suffered from went on laparoscopic radical resection carcinoma Peking University Shougang Hospital Feb. 2015 Mar. 2016 were included study. They randomly divided into two groups. 23 operated with system compared by perioperative data. There no significant differences age, sex, pathological type, tumor differentiation, TNM staging, surgical...
Diabetes mellitus (DM) contributes to intervertebral disc degeneration (IDD). The long non‑coding RNA MALAT1 has been revealed play an important role in diabetes‑associated complications. However, the specific of IDD not determined. aim present study was evaluate roles apoptosis cartilage endplate (CEP) cells induced by high glucose and explore mechanisms underlying this effect. Rat CEP were cultured high‑glucose medium (25 mM glucose) for 24 or 72 h. Cells containing 5 used as a control....
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus (DM). Schwann cell (SC) apoptosis contributes to the occurrence and development DPN. Effective drugs prevent SC are required relieve reverse nerve injury caused by DM. Oltipraz [4-methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione], an agonist nuclear factor erythroid derived-2-related 2 (Nrf2), exerts strong effect against oxidative stress in animal models or clinical patients certain diseases, including heart...
Ectopic fat deposition in the liver, known as non-alcoholic fatty liver disease (NAFLD), affects up to 30% of worldwide population. miRNA-122, most abundant liver-specific miRNA, protects hepatic steatosis and inhibits cholesterol acid synthesis NAFLD. Previously, we have shown that compared with its expression healthy controls, miRNA-122 decreased tissue but gradually increased serum patients steatohepatitis, suggesting could been transported serum. Here, aimed confirm unravel mechanism...
Previous studies have indicated that cellular senescence is a critical underlying mechanism of intervertebral disc degeneration. However, the precise by which accelerates degeneration has not been fully elucidated. Caveolin‑1 recently emerged as an important regulator senescence. Therefore, aim present study was to investigate whether caveolin‑1 involved in nucleus pulposus (NP) during oxidative stress. PCR used detect mRNA expression and protein detected western blotting. at levels markedly...
Heregulin‑1β is capable of promoting the nerve regeneration acellular allografts with skin‑derived precursor differentiated Schwann cell (SC) therapy in peripheral injury. Long non‑coding RNAs (lncRNAs) serve important roles regulation gene transcription and trans-lation multiple biological processes, but its association repair injury unexplored. Therefore, present study, aim was to identify novel indicators for injury, detect whether there an between lncRNA expression treatment effect...
Approximately 30%-50% of colorectal cancers (CRCs) harbor the somatic mutated KRAS gene. G12V, one most common mutations in CRCs, is linked to increased tumor aggressiveness, less response anti-epidermal growth factor receptor (EGFR) therapy, and poor survival rate. In this study, we sought determine whether resistance EGFR inhibitors cancer cells harboring G12V mutation associated with hypoxia. Our data indicated that HIF-1α was induced by signaling at transcription level. Hypoxia or...
Abstract Background Circulating tumor DNA (ctDNA) detection following curative-intent surgery could directly reflect the presence of minimal residual disease, ultimate cause clinical recurrence. However, ctDNA is not postoperatively detected in ≥ 50% patients with stage I-III colorectal cancer (CRC) who ultimately recur. Herein we sought to improve recurrence risk prediction by combining clinicopathological factors CRC. Methods Two independent cohorts, both consisting early-stage CRC...
Background: A high prevalence of autoimmune thyroid disease (AITD) has been observed in patients with liver (AILD); however, data on the clinical relationship between AILD and AITD remain scant. We aimed to evaluate AITD.Methods: performed a retrospective study using medical records from 324 AILD, 113 whom had concurrent AITD.Results: Patients hepatitis (AIH) were more likely develop (45.8%), followed by hepatitis-primary biliary cholangitis overlap syndrome (AIH-PBC OS) (39.5%) PBC (22.6%)....