Background: Cancer stem cells (CSCs) possess the characteristics associated with normal and are responsible for cancer initiation, recurrence, metastasis. CD133 is regarded as a CSCs marker of osteosarcoma, which most common primary bone malignancy in childhood adolescence. Salinomycin, polyether ionophore antibiotic, has been shown to kill various CSCs, including osteosarcoma CSCs. However, salinomycin displayed poor aqueous solubility that hinders its clinical application. The objective...

Conversion to total hip arthroplasty (CTHA) is a relatively common procedure after failed dynamic screw (DHS) or proximal femoral nail anti-rotation (PFNA) fixation of intertrochanteric fractures, but there have been far fewer reports specifically describing the long-term results CTHA treatments stable fractures with DHS PFNA. The aim present study was compare clinical and radiological outcomes PFNA fixations minimum follow-up 3 years.Between January 2005 April 2014, we retrospectively...

Osteosarcoma is a common childhood bone cancer with poor survival rate. stem cells (CSCs) contribute to the recurrence, drug resistance and metastasis of this disease. Previous evidence suggested that are able spontaneously turn into CSCs, thus it crucial simultaneously target osteosarcoma CSCs. Our previous studies have demonstrated salinomycin preferably eliminated In addition, amplification epidermal growth factor receptor (EGFR) genetic aberration in osteosarcoma, EGFR promising...

Objectives To compare the long-term functional and radiographic outcomes of proximal femoral nail antirotation-Asia (PFNA-II) INTERTAN (IT) in management intertrochanteric fractures (IFFs) (AO/OTA Type 31A1.1-A2.3) elderly patients with primary osteoporosis. Methods A retrospective comparative study was performed our institution. From January 2009 to March 2012, 243 osteoporosis (243 hips) IFFs 3.1A1.1-A2.3) underwent repair either a PFNA-II or IT. Follow-up assessments were 1, 3, 6, 9, 12...

The purpose of this study was to evaluate whether PFNA-II (Asia proximal femoral nail anti-rotation) and DHS (dynamic hip screw) carry substantial post-operative hidden blood loss compare with in terms elderly high-risk patients intertrochanteric femur fractures(IFFs). clinical data from Jan 2005 Apr 2015 186 177 were analyzed retrospectively. Indexes including pre- routine, intra- transfusion situation analyzed. perioperative (visible hidden) assessed. intra-operative the group 34.7 ± 2.5...

Objective To evaluate long-term radiographic and functional outcomes between dynamic hip screw (DHS) proximal femoral nail antirotation (PFNA) fixation for treatment of osteoporotic type 31-A1 intertrochanteric fractures (IFFs) among elderly patients Methods A retrospective comparative study was carried out. Follow-up performed at 1, 3, 6, 9, 12 months postoperatively yearly thereafter. The primary outcome the outcome, secondary outcome. Results significant difference in complications...

Many studies aimed at investigating bone repair have been conducted through animal models in recent years. However, limitations do exist these due to varying regeneration potential among different species. Even using the same animal, big differences size of critical defects (CSD) involving region. This study investigate standardization radial defect rabbits and further establish more reliable CSD data. A total 40 6-month-old New Zealand white clean grade totaling 80 bones were prepared for...

A unique structural transition from pomegranate-like monodisperse mesoporous silica microspheres (M-MSMs) with tunable mesopores to microcapsules has been reported. The evolution occurred together varying the cross-linking degrees (CLDs) of templates. Herein, using sulfonated cross-linked polystyrene (S-CLPS) as templates, S-CLPS/SiO2 composite were synthesized by sol–gel method. Subsequently, templates removed calcination obtain M-MSMs or microcapsules. pore sizes could be tailored 3.2 7.4...

In high-frequency over-the-horizon radar (OTHR), it is a challenging work to detect targets in the nonhomogeneous range-Doppler (RD) map with multitarget interference and sharp/smooth clutter edges. The intensity transition of edge may be sharp or smooth due coexistence atmospheric noise, sea clutter, ionospheric OTHR. analysis RD shows spatial correlation among neighboring cell-under-test (CUT) that varies from clutter. This article proposes an algorithm uses relationship estimate...

Cyclophilin A (CyPA) is a cytosolic receptor of immunosuppressive drug cyclosporin (CsA) which possesses peptidyl-prodyl cis/trans isomerase (PPIase) activity. The recombinant human CyPA (rhCyPA) gene has been expressed in E. coli M15. Purification was performed using salting-out, as well Sephacryl S-100 and DEAE-Sepharose CL-6B column chromatography. molecular weight about 18 kDa, confirmed by SDS-PAGE mass spectrum. results Native-PAGE immunoblotting showed the existence three bands,...

Abstract: Acute unstable complex radial head and neck fractures in adults are seldom reported the literature. Early recognition appropriate management essential to prevent long-term consequences of loss elbow function, forearm rotation, chronic pain. Here, we describe an unusual case a 20-year-old man who exhibited acute right radius without other injuries or comorbidity. An open reduction mini T-shaped plate fixation were performed within 3 hours after injury, results satisfactory. A long...

Objective This study was performed to compare the clinical outcomes of traditional three-dimensional (3D) printing technology and 3D mirror model in treatment isolated acetabular fractures. Methods Prospectively maintained databases were reviewed retrospectively patients with an fracture who treated (Group T) or M) from 2011 2017. In total, 146 advanced-age (146 hips) T, n = 72; Group M, 74) assessed for a mean follow-up period 29 months (range, 24–34 months). The primary endpoint...

Accurate merchandise sales forecasts increase the turnover rate for merchants' benign inventory stocking, formulate cost budget items, effective strategies according to time and local conditions, provide theoretical basis reasonable strategies. However, traditional methods of forecasting are not comprehensive actual effect is ideal. Use ARIMA model fit original product series, extract main deterministic information in series through factor decomposition method, subtract or remove trend...

Introduction: The aim of this retrospective study was to evaluate the outcomes older patients with 2-part proximal humerus fractures (PHFs) medial column disruption stabilized using a humeral internal locking system (PHILOS) plate plus oblique insertion autologous fibula as primary procedure. Materials and Methods: Data involving 112 (112 shoulders) sustaining PHFs treated PHILOS procedure during 2012-2019 were identified. median follow-up 36 months (range: 11.2-43.5 months). endpoint...