Lei Cao

ORCID: 0000-0002-0535-0937
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Research Areas
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Cancer Immunotherapy and Biomarkers
  • CAR-T cell therapy research
  • Lung Cancer Treatments and Mutations
  • Birth, Development, and Health
  • Neonatal and fetal brain pathology
  • Immunotherapy and Immune Responses
  • Stress Responses and Cortisol
  • Banking stability, regulation, efficiency
  • Orthopaedic implants and arthroplasty
  • Hip disorders and treatments
  • Bacillus and Francisella bacterial research
  • Reproductive System and Pregnancy
  • Neuroscience and Neuropharmacology Research
  • Community-based Tourism Development and Sustainability
  • Geotourism and Geoheritage Conservation
  • Blood Coagulation and Thrombosis Mechanisms
  • Inflammatory Biomarkers in Disease Prognosis
  • Tryptophan and brain disorders
  • Genetically Modified Organisms Research
  • Surgical Sutures and Adhesives
  • Protease and Inhibitor Mechanisms
  • Anesthesia and Neurotoxicity Research
  • Surgical site infection prevention
  • Epigenetics and DNA Methylation

TianjinSino-German University of Applied Sciences
2025

Shanghai Jiao Tong University
2024

Songjiang District Central Hospital
2024

University of Electronic Science and Technology of China
2024

Tianjin University
2024

Anhui Medical University
2009-2022

Peking Union Medical College Hospital
2004-2022

Chinese Academy of Medical Sciences & Peking Union Medical College
2004-2022

Second Hospital of Anhui Medical University
2009-2022

Huazhong University of Science and Technology
2017

We investigate the role of multiple large shareholders in risk-taking behaviour commercial banks by analysing a sample Chinese for period 2010–2021. The findings suggest that with have lower than those single shareholder. monitoring power other is inversely related to bank risk-taking. Furthermore, moderating impact characteristics on relationship between and significant.

10.1080/13504851.2024.2446482 article EN Applied Economics Letters 2025-01-06

Cerebral ischemia is caused by various disorders, such as stroke, myocardial infarction, or peripheral vascular disease. The purpose of this paper was to investigate the effects glycyrrhizic acid (GA) on cerebral ischemia/reperfusion (I/R) injury. Middle artery occlusion established evaluate GA ischemia. In study, our results showed that could dramatically decrease edema, reduce neurological deficits, and smaller brain infarct volume found in treatment group. serum tissue, also increased...

10.1002/bab.1825 article EN Biotechnology and Applied Biochemistry 2019-09-23

Chimeric antigen receptor-T (CAR-T) cells have limited therapeutic efficacy against solid tumors, partially due to their ability reach and invade into the neoplastic foci. By gene expression profiling interactive analysis, we identified that C-C motif chemokine ligand (CCL) 20 is highly expressed in lung other most incidence and/or mortality cancers such as colon, rectum, stomach, liver cancers. Forced of receptor 6 (CCR6), biunique CCL20, results robust trafficking CAR-T toward...

10.1016/j.scib.2020.12.027 article EN cc-by-nc-nd Science Bulletin 2020-12-29

Objective To evaluate long-term radiographic and functional outcomes between dynamic hip screw (DHS) proximal femoral nail antirotation (PFNA) fixation for treatment of osteoporotic type 31-A1 intertrochanteric fractures (IFFs) among elderly patients Methods A retrospective comparative study was carried out. Follow-up performed at 1, 3, 6, 9, 12 months postoperatively yearly thereafter. The primary outcome the outcome, secondary outcome. Results significant difference in complications...

10.1177/0300060517703277 article EN cc-by-nc Journal of International Medical Research 2017-04-18

Lung cancer is the leading cause of cancer-related deaths worldwide, and its occurrence related to accumulation gene mutations immune escape tumor. Sequencing T-cell receptor (TCR) repertoire can reveal immunosurveillance status tumor microenvironment, which immunotherapy. This study aimed determine characteristics clinical significance TCR in lung cancer. To comprehensively profile repertoire, results from high-throughput sequencing samples 93 Chinese patients with were analyzed. We found...

10.3389/fonc.2021.537735 article EN cc-by Frontiers in Oncology 2021-03-11

This study takes Cangshan UNESCO Global Geopark as an example, which the connection between tourism and economic departments starting point, adopts appropriate development methods, determines that tourists are one of most important stakeholder groups in development. Based on this, this aims to explore tourists' cognition support for sustainable Geopark. In study, a self-administered questionnaire survey method is used construct tourist satisfaction evaluation model Mount Cangshan, various...

10.5814/j.issn.1674-764x.2024.02.025 article EN Journal of Resources and Ecology 2024-03-26

The triglyceride glucose (TyG) index, defined as Ln [fasting (mg/dL) × fasting (mg/dL)/2], provides insights into overall metabolic status. However, the association between TyG index and gout has not been investigated. Therefore, this study explored correlation gout.

10.1186/s12902-024-01747-6 article EN cc-by-nc-nd BMC Endocrine Disorders 2024-10-16

Abstract Introduction Infections could contribute to Alzheimer's disease (AD) neuropathology in human. However, experimental evidence for a causal relationship between infections during the prenatal phase and onset of AD is lacking. Methods CD‐1 mothers were intraperitoneally received lipopolysaccharide (LPS) with two doses (25 50 μg/kg) or normal saline every day gestational days 15–17. A battery behavioral tasks was used assess species‐typical behavior, sensorimotor capacity, anxiety,...

10.1002/brb3.1546 article EN cc-by Brain and Behavior 2020-01-30

Age-associated impairment of spatial learning and memory ability (AISLM) presents substantial challenges to our health society. Increasing evidence indicates that embryonic exposures inflammation accelerate AISLM, which could be attributable changed synaptic plasticity associated various proteins at certain extent. However, it is still uncertain whether the factors social psychology affect this AISLM genes expression proteins. Synaptotagmin-1 (Syt-1) activity-regulated...

10.3389/fnagi.2020.00157 article EN cc-by Frontiers in Aging Neuroscience 2020-07-06

Gestational infection causes various neurological deficits in offspring, such as age-related spatial learning and memory (SLM) decline. How inflammation SLM dysfunction remains unknown. Previous research has indicated that histone modifications, phosphorylation of H3S10 (H3S10p) trimethylation H3K9 (H3K9me3) may be involved. In our study, pregnant mice received an intraperitoneal injection lipopolysaccharide (LPS, 50 or 25 μg/kg) normal saline during gestational days 15-17. After...

10.3389/fnagi.2019.00114 article EN cc-by Frontiers in Aging Neuroscience 2019-05-16

Purpose. Red blood cell distribution width (RDW) is increased in a variety of inflammatory-related diseases. However, there no report its clinical significance poststroke depression (PSD). This study explores the RDW PSD patients. Methods. A total 185 patients with first-ever acute ischaemic stroke (AIS) Second Hospital Anhui Medical University were chosen as subjects. retrospective observational was conducted from February 2019 to 2020. diagnosed at 6 months after based on Diagnostic and...

10.1155/2021/8361504 article EN Computational and Mathematical Methods in Medicine 2021-07-19

Previous studies have shown that gestational inflammation can accelerate age-associated cognitive decline (AACD) in maternal mice; enriched environments (EEs) been reported to protect normally aging mice from AACD and improve mitochondrial function. However, it is unclear whether the nitrosative stress-related proteins tet methylcytosine dioxygenase 1 (TET1) S-nitrosoglutathione reductase (GSNOR) are involved accelerated process of EEs slow this process.In study, CD-1 female on 15th day...

10.1002/brb3.2817 article EN cc-by Brain and Behavior 2022-11-21

Abstract This meta‐analysis systematically evaluates the impact of negative‐pressure wound therapy (NPWT) on surgical‐site infection after vascular surgery. A comprehensive computerized search was conducted, from database inception to November 2023, in PubMed, Embase, Google Scholar, Cochrane Library, China National Knowledge Infrastructure, and Wanfang databases for randomized controlled trials (RCTs) application NPWT Two researchers independently screened literature, extracted data,...

10.1111/iwj.14695 article EN cc-by-nc International Wound Journal 2024-01-31
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