A5091793839- CAR-T cell therapy research
- Intracranial Aneurysms: Treatment and Complications
- Virus-based gene therapy research
- Metabolomics and Mass Spectrometry Studies
- Epigenetics and DNA Methylation
- Dental materials and restorations
- Genetic Syndromes and Imprinting
- Neurological Disease Mechanisms and Treatments
- Nitric Oxide and Endothelin Effects
- Photosynthetic Processes and Mechanisms
- RNA modifications and cancer
- Robotic Mechanisms and Dynamics
- Tea Polyphenols and Effects
- Pregnancy and preeclampsia studies
- Pelvic and Acetabular Injuries
- Cryptography and Data Security
- Food Quality and Safety Studies
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Endodontics and Root Canal Treatments
- vaccines and immunoinformatics approaches
- Telecommunications and Broadcasting Technologies
- Phytase and its Applications
- Digital Media Forensic Detection
- Insect and Pesticide Research
Yanan University Affiliated Hospital
2023
Sun Yat-sen University
2017-2022
Shanghai Cell Therapy Research Institute
2018-2022
Sixth Affiliated Hospital of Sun Yat-sen University
2021-2022
Second Hospital of Shandong University
2022
The First Affiliated Hospital, Sun Yat-sen University
2017-2021
China University of Mining and Technology
2017-2021
China Tobacco
2016-2021
Tea Research Institute
2018-2019
Northwest Normal University
2019
Abstract Mesothelin (MSLN) is an attractive antigen for chimeric receptor (CAR) T therapy and the epitope selection within MSLN essential. In this study, we constructed two types of CARs targeting either region I (meso1 CAR, also known as a membrane-distal region) or III (meso3 membrane-proximal using modified piggyBac transposon system. We reported that, compared with meso1 CAR cells, meso3 cells express higher levels CD107α upon activation produce increased interleukin-2, TNF-α, IFN-γ...
Cerebral vasospasm (CVS) and early brain injury remain major causes of morbidity mortality after aneurysmal subarachnoid hemorrhage (SAH). Hydroxymethylglutaryl coenzyme A reductase inhibitors, also known as statins, has the neuroprotective effects ameliorating CVS SAH. This study was designed to explore apoptosis inhibiting atorvastatin its potential apoptotic signal pathway Preserving blood-brain-barrier permeability, decreasing edema, increasing neurological scores cerebral were obtained...
Vibrio fischeri bioluminescence inhibition has been widely used to test acute toxicities of metals and organics contaminants. However, the differences V. have not compared. Here, four heavy (Zn2+, Cu2+, Cd2+, Cr6+) five (phenol, benzoic acid, p-hydroxy nitro-benzene benzene) were investigated. Heavy increased along with reaction time, while kept same level in different times. In order explain difference, relative cell death rate was detected. tests, found be significantly higher than...
Nonviral transposon piggyBac (PB) and lentiviral (LV) vectors have been used to deliver chimeric antigen receptor (CAR) T cells. To understand the differences in effects of PB LV on CAR T-cell functions, a targeting CD19 was cloned into vectors, resulting pbCAR lvCAR were delivered cells generate CD19pbCAR CD19lvCAR Both CD19CAR types strongly cytotoxic secreted high IFN-γ levels when incubated with Raji TNF-α increased cells, whereas IL-10 showed similar strong anti-tumor activity...
To investigate the placental characteristics in selective intrauterine growth restriction (sIUGR) using gradient angiography and three-dimensional (3D) reconstruction from computed tomography (CT) scan data.This study included 23 sIUGR cases 16 monochorionic twin-pregnancies without sIUGR. We injected nonionic iodinated contrast agents into umbilical arteries veins. Placental were analyzed after CT scanning 3D reconstruction.73.9% of smaller twins had marginal or velamentous cord insertions...
Scientists have developed smart shape memory materials that can adapt their structure or function to external stimuli. The demand for dynamic oral bone tissue repair is driven by continuous changes in and surrounding tissues during the process, such as tooth growth, movement, reconstruction of soft tissues, well skeletal differences alveolar craniofacial bones. These challenge mechanical stability implants precision printing. Consequently, 4D printing technology introduces "time", allowing...
As non-viral transgenic vectors, the piggyBac transposon system represents an attractive tool for gene delivery to achieve a long-term expression in immunotherapy applications due its large cargo capacity, lack of trace and genotoxic potential, highly engineered structure. However, further improvements transpose activity are required industrialization clinical applications. Herein, we established one-plasmid effective screening two-step high-throughput process yeast isolate hyperactive...
Phytosterols have been demonstrated to be precursors of polycyclic aromatic hydrocarbons (PAHs) formed during biomass pyrolysis. Here, a novel Paenibacillus sp. was evaluated for its ability degrade phytosterols in tobacco waste extract (TWE). The optimal conditions cell growth and stigmasterol (a representative phytosterols) degradation were 37 °C, pH 7.0, 1.0 g/L yeast extract, 6.0 glucose. could under high concentrations glucose (up 130 g/L) tolerate wide (5.0-9.0) temperature (25-42 °C)...
CDKN1C and KCNQ1OT1 are imprinted genes that might be potential regulators of placental development. This study investigated expressions in monozygotic twins with without selective intrauterine growth restriction (sIUGR). Seventeen sIUGR fifteen normal monozygotic(MZ) twin pairs were examined. Placental mRNA detected by real-time fluorescent quantitative PCR. protein expression was immunohistochemical assay Western-blotting. In the group, smaller fetuses had a share placenta, significantly...
Aberrant DNA methylation pattern plays an indispensable role in the initiation and development of head neck squamous cell carcinoma (HNSCC). It is well recognized that lymph node metastasis closely with unfavorable prognosis HNSCC. Therefore, exploring events accounting for HNSCC very important improving clinical outcome Methylation data, RNA-seq data were downloaded from The Cancer Genome Atlas (TCGA) processed using R package TCGA-Assembler. MethylMix was use analysis by integrating both...
Abstract In this present study, silver nanoparticles (AgNPs) immobilized hydrochar was prepared through a facile one-pot co-hydrothermal carbonization of tobacco stem and nitrate. The effect concentration precursor, hydrothermal temperature reaction time on the chemical compositions, structural property, combustion performance, as well gaseous products release behavior resultant AgNPs were evaluated. treatment decreased volatile matter while increased ash content hydrochar. Single-phase...
Currently, the choice of treatment for individuals with metastatic soft tissue sarcomas (MSTS) presents a significant challenge to clinicians. The aim this retrospective study was assess efficacy and safety nivolumab plus ipilimumab (NPI) versus alone (NIV) in treatment-naive programmed death-ligand 1 (PD-L1) positive MSTS.Prospectively maintained databases were reviewed from 2013 2018 PD-L1 MSTS who received NPI (nivolumab 3 mg/kg every weeks 4 doses followed by 2 weeks) or NIV (3 until...