A5089092641- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- Intracranial Aneurysms: Treatment and Complications
- Viral gastroenteritis research and epidemiology
- Intracerebral and Subarachnoid Hemorrhage Research
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Ferroptosis and cancer prognosis
- Viral Infections and Vectors
- Epigenetics and DNA Methylation
- Hormonal Regulation and Hypertension
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- Bacteriophages and microbial interactions
- Nitric Oxide and Endothelin Effects
- Birth, Development, and Health
- Metabolomics and Mass Spectrometry Studies
- interferon and immune responses
- Vascular Malformations Diagnosis and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Cardiac Fibrosis and Remodeling
University of South Florida
2025
Université de Montréal
2025
Harbin Medical University
2010-2024
First Affiliated Hospital of Harbin Medical University
2010-2024
China Tobacco Guangxi Industrial (China)
2024
Nanjing University of Science and Technology
2024
Heilongjiang University
2023-2024
Honghu People’s Hospital
2024
Soochow University
2023
University of Macau
2022
Cereals are a major dietary source of the toxic metal cadmium (Cd). Reducing Cd accumulation in cereal crops such as wheat (Triticum aestivum) is important for food safety and human health. In this study, we show that three diverse cultivars had high translocation from roots to shoots, similar rice (Oryza sativa) cultivar possessing nonfunctional tonoplast transporter OsHMA3. We investigated function TaHMA3 genes wheat. Three were identified wheat, all which encode tonoplast-localized...
Phaeodactylum tricornutum is considered a potential lipid production platform due to its high growth rates and elevated natural neutral polyunsaturated fatty acid (PUFA) contents. Furthermore, microalgae are emerging as promising sources of docosahexaenoic (DHA) eicosapentaenoic (EPA). In this study, phosphomolybdic (PMo 12 ), photocatalyst, can enhance the synthesis lipids PUFAs by influencing expression metabolism-related genes photosynthesis in P. tricornutum. We also observed contents...
Cerebral vasospasm (CVS) and early brain injury remain major causes of morbidity mortality after aneurysmal subarachnoid hemorrhage (SAH). Hydroxymethylglutaryl coenzyme A reductase inhibitors, also known as statins, has the neuroprotective effects ameliorating CVS SAH. This study was designed to explore apoptosis inhibiting atorvastatin its potential apoptotic signal pathway Preserving blood-brain-barrier permeability, decreasing edema, increasing neurological scores cerebral were obtained...
The newly highlighted research into programmed cell death (PCD), autophagy dependent and pyroptotic death, has shown that these processes are both strongly correlated with the pathological progression of traumatic brain injury (TBI). However, their cross-talk in TBI remains unclear. Here, a moderate model was established to explore relationship between pyroptosis. Rapamycin used activate process autophagy, which impaired model, this treatment reversed expression pyroptosis associated...
Interleukin-33 (IL-33) is a member of the interleukin-1 (IL-1) cytokine family and an extracellular ligand for orphan IL-1 receptor ST2. Accumulated evidence shows that IL-33/ST2 axis plays crucial role in pathogenesis central nervous system (CNS) diseases injury, including traumatic brain injury (TBI). However, roles molecular mechanisms after TBI remain poorly understood. In this study, we investigated signaling mouse TBI-induced edema neurobehavioral deficits, further exploited underlying...
5-hydroxymethylcytosine, also known as the sixth DNA base of genome, plays an important role in brain aging and neurological disorders such Alzheimer's disease. However, little is about its genome-wide distribution association with disease pathology. Here, we report a profiling 5-hydroxymethylcytosine 1079 autopsied brains (dorsolateral prefrontal cortex) older individuals assess multiple measures pathologies, including pathological diagnosis disease, amyloid-β load, PHFtau tangle density....
Hydrogen sulfide (H2S), an important endogenous signaling molecule, has a significant neuroprotective role in the central nervous system. In this study, we examined protective effects of exogenous H2S against intracerebral hemorrhage (ICH), as well its underlying mechanisms. We investigated on ICH using Western blotting, injury volume, measurement brain edema, propidium iodide (PI) staining, and behavior assessment, respectively. found that production was downregulated after ICH, which is...
In patients with traumatic brain injury (TBI) combined long bone fracture, the fracture healing is always faster than that of single which characterized by more callus growth at site and even ectopic ossification. Exosomes are nanoscale membrane vesicles secreted cells, contain cell-specific proteins, miRNAs, mRNAs.In this study, we used exosomes as entry point to explore mechanism trauma promoting healing. We established a model tibia TBI in mice observe expression osteogenic factors site....
Experimental autoimmune myocarditis (EAM) in rats is a T-cell-mediated disorder and has been shown to involve immune imbalance. The aim of this study was examine the immunomodulatory effects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitor, atorvastatin, on expression MHC class II molecules myocardium with EAM, its therapeutic potential for EAM. EAM induced Lewis by injection porcine cardiac myosin. High-dosage (10 mg/kg per day) or low-dosage (1 atorvastatin vehicle given orally 3...