A5074295469- Viral Infections and Immunology Research
- Monoclonal and Polyclonal Antibodies Research
- Gout, Hyperuricemia, Uric Acid
- Rheumatoid Arthritis Research and Therapies
- Pharmacological Effects of Natural Compounds
- Cardiac Fibrosis and Remodeling
- Liver Disease Diagnosis and Treatment
- Neonatal Respiratory Health Research
- interferon and immune responses
- Atherosclerosis and Cardiovascular Diseases
- Cytokine Signaling Pathways and Interactions
- Spondyloarthritis Studies and Treatments
- Hearing Loss and Rehabilitation
- Hepatitis B Virus Studies
- Glioma Diagnosis and Treatment
- Healthcare and Venom Research
- Ideological and Political Education
- Salivary Gland Disorders and Functions
- Hearing, Cochlea, Tinnitus, Genetics
- Inflammasome and immune disorders
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Toxin Mechanisms and Immunotoxins
- Ear Surgery and Otitis Media
- Medical Imaging and Pathology Studies
Capital Medical University
2014-2025
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2011-2025
Beijing Children’s Hospital
2020-2025
Beijing Shijitan Hospital
2025
Center for Children
2025
Saarland University
2025
Shuguang Hospital
2024
Shanghai University of Traditional Chinese Medicine
2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2024
Huazhong University of Science and Technology
2006-2024
Some patients with COVID-19 pneumonia also present kidney injury, and autopsy findings of who died from the illness sometimes show renal damage. However, little is known about clinical characteristics kidney-related complications, including hematuria, proteinuria, AKI.
Cerebral vasospasm (CVS) and early brain injury remain major causes of morbidity mortality after aneurysmal subarachnoid hemorrhage (SAH). Hydroxymethylglutaryl coenzyme A reductase inhibitors, also known as statins, has the neuroprotective effects ameliorating CVS SAH. This study was designed to explore apoptosis inhibiting atorvastatin its potential apoptotic signal pathway Preserving blood-brain-barrier permeability, decreasing edema, increasing neurological scores cerebral were obtained...
The goal of cancer immunotherapy is the generation an effective, stable, and self-renewing antitumor T-cell population. One such approach involves use high-affinity cancer-specific receptors in gene-therapy protocols. Here, we present functional tumor-specific human T cells vivo from genetically modified hematopoietic stem (hHSC) using a human/mouse chimera model. Transduced hHSC expressing HLA-A*0201–restricted melanoma-specific receptor were introduced into humanized mice, resulting...
OBJECTIVE To determine the relationship between subclinical hypothyroidism (SCH) and prevalence of diabetic retinopathy in type 2 patients. RESEARCH DESIGN AND METHODS A total 1,170 patients were screened for thyroid function. There 127 with SCH 200 randomly selected euthyroid selected. Those more severe than moderate nonproliferative classified as having sight-threatening (STDR). RESULTS The trend was significantly higher group (χ2 = 20.43, P 0.000). associated greater retinopathy,...
Acute Gouty Arthritis (AGA) is characterized by a rapid inflammatory reaction caused the build-up of monosodium urate (MSU) crystals in tissues surrounding joints. This condition often associated with hyperuricemia, distinguished its symptoms intense pain, active inflammation, and swelling Traditional approaches AGA management fall short desired outcomes clinical settings. However, recent ethnopharmacological investigations have been focusing on potential Herbal Medicine (THM) various forms,...
Circulating tumor stem cells (CTSC), a subpopulation of circulating (CTC), may lead to recurrent diseases. The aim this study was detect CTC (CD45−EpCAM+) and CTSC (CD45−EpCAM+CD44+CD24−) breast cancer (BC) patients, as well explore their clinical relevance. in peripheral blood (PB) 45 female BC patients were detected by using flow cytometry (FCM). SKBR-3 mixed with MNC four healthy volunteers at different ratios order evaluate the sensitivity FCM. Real-time quantitative polymerase chain...
Pelvic floor dysfunction (PFD) is a group of clinical conditions including stress urinary incontinence (SUI) and pelvic organ prolapse (POP). The abnormality collagen elastin metabolism in connective tissues implicated SUI POP.To reconstitute the with normal distribution elastin, we transduced to bone marrow-derived mesenchymal stem cells (BMSC). Elastin-expressing BMSCs were then differentiated fibroblasts using bFGF, which produced elastin. To achieve sustained release formulated bFGF poly...
Background . Huangqi Guizhi Wuwu Decoction (HGWD) has been applied in the treatment of joint pain for more than 1000 years China. Currently, most physicians use HGWD to treat rheumatoid arthritis (RA), and it proved have high efficacy. Therefore, is necessary explore potential mechanism action RA based on network pharmacology molecular docking methods. Methods The active compounds were collected, their targets identified from Traditional Chinese Medicine Systems Pharmacology Database (TCMSP)...
Ankylosing spondylitis (AS) is a chronic autoimmune disease characterized by inflammation of the sacroiliac joints and spine. Cuproptosis newly recognized copper-induced cell death mechanism. Our study explored novel role cuproptosis-related genes (CRGs) in AS, focusing on immune infiltration molecular clustering. By analyzing peripheral blood gene expression datasets obtained from GSE73754, GSE25101, GSE11886, we identified patterns cellular factors related to cuproptosis. Subsequently,...
Purpose: Baicalin is a flavonoid of Scutellaria baicalensis Georgi. It possesses antipyretic, analgesic, and anti-inflammatory effects. has great potential to treat gout. A network pharmacology approach, molecular docking experimental validation were applied investigate the pharmacological mechanisms baicalin in treating Methods: The targets retrieved from TCMSP, PharmMapper, STITCH, Swiss Target Prediction databases. gout-related DrugBank, TTD, Genecards Then, signaling pathways acquired...
Backgrounds It remains unclear whether LVAS pediatric patients experience more severe subjective symptoms after surgery compared to other patients, their objective vestibular function is worse, and the underlying reasons for poorer experience.
This study aimed to explore the relationship between endometrial thickness and lesions in asymptomatic postmenopausal women identify diagnostic thresholds for lesions. A total of 279 aged 40 years or older with ≥ 4 mm were retrospectively selected our hospital, from January 2018 June 2023, there 33 cases's operations which failed due cervical stenosis, 8cases who used hormone replacement therapy within past year, 7 cases hysteromyoma that affect shape uterine cavity line, 5cases's...
To analyse the quantitative morphology of menisci, their roots and relations with a focus on medial meniscus anterior root (MAR) as basis for preclinical model. Data was obtained from 24 tibial plateaus skeletally mature, female Merino ewes. The MAR attachment (MARA) scanned micro-computed tomography stained hematoxylin eosin. relevant anatomical structures subjected to principal component analysis (PCA) Spearman correlations. osteo-ligamentous junction MARA represents classical enthesis...
Abstract Background In Traditional Chinese Medicine (TCM) theory, cold dampness obstruction is one of the common syndromes osteoarthritis. Therefore, in clinical practice, main treatment methods are to dispel wind, remove dampness, and dissipate cold, used treat knee osteoarthritis (KOA). This report describes a mulitercenter study assess Zhuifeng Tougu Capsule’s efficacy safety patients who syndrome KOA, provide evidence-based medical for rational use Capsules practice. Methods randomized,...
Abstract The role of KIAA0040 in glioma development is not yet understood despite its connection to nervous system diseases. In this study, expression levels were evaluated using qRT‐PCR, WB and IHC, functional assays conducted assess impact on progression, along with animal experiments. Moreover, was used examine the JAK2/STAT3 signalling pathway. Our study found that increased linked tumour grade poor clinical outcomes, serving as an independent prognostic factor. Functional showed...
Abstract Background Pelvic floor dysfunction (PFD) is a condition affecting many women worldwide, with symptoms including stress urinary incontinence (SUI) and pelvic organ prolapse (POP). We have previously demonstrated stable elastin-expressing bone marrow-derived mesenchymal stem cells (BMSCs) attenuated PFD in rats, aim to further study the effect of microRNA-29a-3p regulation on elastin expression efficacy BMSC transplantation therapy. Methods inhibited endogenous BMSCs investigated its...