A5100414293- Rheumatoid Arthritis Research and Therapies
- Bone and Dental Protein Studies
- dental development and anomalies
- Spondyloarthritis Studies and Treatments
- Osteoarthritis Treatment and Mechanisms
- Systemic Lupus Erythematosus Research
- Bone and Joint Diseases
- Oral microbiology and periodontitis research
- Monoclonal and Polyclonal Antibodies Research
- Autoimmune and Inflammatory Disorders Research
- Oral and Maxillofacial Pathology
- Natural product bioactivities and synthesis
- Traditional Chinese Medicine Analysis
- Xenotransplantation and immune response
- Enhanced Recovery After Surgery
- Eosinophilic Esophagitis
- Ocular Diseases and Behçet’s Syndrome
- Proteoglycans and glycosaminoglycans research
- Pelvic floor disorders treatments
- Cardiac Fibrosis and Remodeling
- GDF15 and Related Biomarkers
- Healthcare and Venom Research
- Omental and Epiploic Conditions
- Spine and Intervertebral Disc Pathology
- Oropharyngeal Anatomy and Pathologies
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2023-2024
Gansu University of Traditional Chinese Medicine
2024
Shanghai University
2023
Shandong University of Traditional Chinese Medicine
2023
Shandong University
2023
Guangzhou Xinhua University
2023
Macau University of Science and Technology
2023
Anhui Xinhua University
2019-2023
Anhui University of Traditional Chinese Medicine
2023
Chengdu Third People's Hospital
2023
DSPP, which plays a crucial role in dentin formation, is processed into the NH(2)-terminal and COOH-terminal fragments. We believe that proteolytic processing of DSPP an essential activation step for its biological function biomineralization. tested this hypothesis by analyzing transgenic mice expressing mutant D452A-DSPP Dspp-knock-out (Dspp-KO) background (referred to as "Dspp-KO/D452A-Tg" mice). employed multipronged approaches characterize Dspp-KO/D452A-Tg mice, comparison with Dspp-KO...
Although the abilities of omentum to alleviate inflammation and prevent infection have been revealed over past decades, underlying mechanisms remain largely unelucidated. Here, we demonstrated that mortality mice exposed cecal ligation puncture (CLP) omentectomy was remarkably increased compared those treated with CLP alone. Moreover, efficacy associated an impairment in intraperitoneal bacterial clearance together increase expression proinflammatory cytokines. Besides, response peritoneal...
Abstract Background In Traditional Chinese Medicine (TCM) theory, cold dampness obstruction is one of the common syndromes osteoarthritis. Therefore, in clinical practice, main treatment methods are to dispel wind, remove dampness, and dissipate cold, used treat knee osteoarthritis (KOA). This report describes a mulitercenter study assess Zhuifeng Tougu Capsule’s efficacy safety patients who syndrome KOA, provide evidence-based medical for rational use Capsules practice. Methods randomized,...
Purpose.: Recent studies have shown that a decrease of regulatory T (Treg) cells may contribute to the activity acute anterior uveitis (AAU) and ankylosing spondylitis (AS). A number immunogenetic factors including IL2RA, miR-27a, miR-182, FoxO1 are associated with Treg cell function. In this study, we investigated association between polymorphisms these genes AAU or without AS in Chinese Han population. Methods.: Using PCR-restricted fragment length polymorphism (RFLP) assay, two-stage...
Deletion or mutation of dentin matrix protein 1 (DMP1) leads to hypophosphatemic rickets and defects within the dentin. However, it is largely unknown if this pathological change a direct role DMP1 an indirect phosphate (Pi) both. It has also been previously shown that Klotho-deficient mice, which displayed high Pi level due failure excretion, causes mild in dentinal structure. This study was address distinct roles homeostasis cell differentiation, apoptosis mineralization enamel. Our...
Dentin sialophosphoprotein ( DSPP ) is a large precursor protein that proteolytically processed into NH 2 ‐terminal fragment [composed of dentin sialoprotein DSP and proteoglycan form ‐ PG )] COOH [dentin phosphoprotein DPP )]. In vitro studies indicate strong initiator regulator hydroxyapatite crystal formation growth, but the role(s) (i.e. in dentinogenesis remain unclear. This study focuses on function dentinogenesis. Here, transgenic T g) mouse lines expressing driven by 3.6‐kb type I...
We have recently proposed that the shared epitope (SE) may contribute to rheumatoid arthritis pathogenesis by acting as a ligand activates proarthritogenic signal transduction events. To examine this hypothesis, in study we characterized novel small SE-mimetic compound, c(HS4-4), containing SE primary sequence motif QKRAA, which was synthesized using backbone cyclization method. The c(HS4-4) compound interacted strongly with receptor calreticulin, potently activated NO and reactive oxygen...
Abstract Aims We aimed to investigate the independent associations between growth differentiation factor 15 (GDF‐15) level at admission and cardiovascular (CV) death, thrombotic events, heart failure (HF), bleeding outcomes in patients with coronary artery disease (CAD). Methods results measured plasma concentrations of GDF‐15 centrally from BIomarker‐based Prognostic Assessment for Stable angina acute Syndrome (BIPass) registry, which consecutively enrolled CAD November 2017 September 2019...
Fam20c is essential for the normal mineralization of dentin and bone. The generation odontoblast osteoblast cell lines carrying floxed allele can offer valuable tools study roles in limited capability primary odontoblasts osteoblasts to proliferate necessitates development serving as substitutes differentiation osteoblasts. In this study, we established characterized immortalized mouse dental papilla mesenchymal lines. isolated cells were by infection lentivirus containing Simian Virus 40...
Objective The mechanisms underlying bone damage in rheumatoid arthritis (RA) are incompletely understood. We recently identified the shared epitope (SE), an HLA–DRB1–coded 5–amino acid sequence motif carried by majority of RA patients as a signal transduction ligand that interacts with cell surface calreticulin and accelerates osteoclast (OC)–mediated collagen‐induced (CIA). Given role SE/calreticulin pathway arthritis‐associated damage, we sought to determine therapeutic targetability...
Abstract Aims Spondyloarthritis (SpA) is an inflammatory rheumatic disease and hip involvement often results in severe deformities functional impairment. Magnetic resonance imaging (MRI) a powerful tool for detecting early lesions SpA. The aims of this study are to apply the inflammation MRI scoring system (HIMRISS) SpA patients evaluate its reproducibility validity. Methods Four readers new HIMRISS (two radiologists two rheumatologists) scored scans obtained from total 55 with separate...
Dentin sialophosphoprotein (DSPP) plays a vital role in dentinogenesis. Previously, we showed that, addition to dentin, DSPP is also highly expressed alveolar bone and cellular cementum, crucial maintaining periodontal integrity; Dspp-deficient mice demonstrate severe defects, including loss, decreased cementum deposition, abnormal osteocyte morphology the bone, apical migration of ligament. dentin cleaved into NH₂ -terminal COOH-terminal fragments. Whilst our previous study that proteolytic...
The aim of this work is to verify the non-inferior efficacy and safety CMAB008 compared with innovator infliximab in rheumatoid arthritis patients combined methotrexate.We conducted a randomized, double-blinded, parallel, positive control design, multicenter study, stable dose methotrexate. Patients were enrolled randomly ratio 1:1 receive intravenously 3 mg/kg or at weeks 0, 2, 6, 14, 22 30. primary endpoint was American College Rheumatology 20% improvement criteria (ACR20) response rate...
Abstract Asperosaponin VI (ASA VI) is a bioactive triterpenoid saponin extracted from Diptychus roots, of Diptyl, and has previously shown protective functions in rheumatoid arthritis sepsis. This study investigates the effects molecular mechanisms ASA on skeletal muscle regeneration cardiotoxin (CTX)‐induced injury mouse model. Mice were subjected to CTX‐induced tibialis anterior C2C12 myotubes treated with CTX. Muscle fiber histology was analyzed at 7 14 days postinjury. Apoptosis...
Many compounds of ginsenosides show anti-inflammatory properties. However, their effects in intervertebral chondrocytes the presence inflammatory factors have never been shown. Increased levels pro-inflammatory cytokines are generally associated with degradation and death chondrocytes; therefore, finding an effective nontoxic substance that attenuates inflammation is worthwhile. In this study, were isolated from nucleus pulposus tissues, cells treated ginsenoside IL-1β, alone combination....
Hip involvement is an important cause of disability and poor prognosis in patients with spondyloarthritis (SpA). Tumor necrosis factor (TNF)-α inhibitor treatment has been demonstrated to be effective SpA hip arthritis; however, quantitative assessment using MRI long-term follow-up needs further application observation.A total 239 were involved this study. Methotrexate sulfasalazine given as basic treatment. In total, 165 received TNF-α inhibitors plus treatment, 74 only, controls. Clinical...
Bony structures around the carotid artery, such as styloid process and hyoid bone, can cause dissection, compression, plaque formation rupture of artery. The present study aimed to a novel case bone elongation causing dissecting aneurysm However, patient had no permanent neurologic symptoms. An 80-year-old man presented with right hemiparesis for >5 h despite preventive therapy antiplatelets statins. Magnetic resonance imaging revealed acute infarction in left parietal lobe....
The objective of the present study was to investigate role Toll-like receptor (TLR)-9 in B lymphocyte stimulating factor (BLyS)-induced systemic lupus erythematosus (SLE) mice. anti-double stranded (ds)DNA antibody titer, levels complement proteins (C3 and C4), interleukin (IL)-10 disease activity [assessed by erythrocyte sedimentation rate (ESR) C-reactive protein (CRP) level] were measured. A total 21 transgenic female mice (aged 8-10 weeks weighing 30-40 g) expressing Epstein-Barr virus...