A5100425679- Spondyloarthritis Studies and Treatments
- Ophthalmology and Visual Impairment Studies
- Systemic Lupus Erythematosus Research
- Psoriasis: Treatment and Pathogenesis
- Corneal surgery and disorders
- Inflammasome and immune disorders
- Rheumatoid Arthritis Research and Therapies
- Dermatology and Skin Diseases
- Osteoarthritis Treatment and Mechanisms
- Ocular Diseases and Behçet’s Syndrome
- Gastrointestinal motility and disorders
- Retinal Diseases and Treatments
- Ophthalmology and Eye Disorders
- Cytomegalovirus and herpesvirus research
- Intraocular Surgery and Lenses
- T-cell and B-cell Immunology
- Assisted Reproductive Technology and Twin Pregnancy
- Autoimmune and Inflammatory Disorders Research
- Folate and B Vitamins Research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Saffron Plant Research Studies
- Tuberous Sclerosis Complex Research
- Congenital gastrointestinal and neural anomalies
- Macrophage Migration Inhibitory Factor
Guangdong Ocean University
2021-2025
Beijing Tongren Hospital
2025
Capital Medical University
2025
Chongqing Medical University
2015-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2015-2024
First Hospital of Shanxi Medical University
2020-2024
Shanxi Medical University
2020-2024
Huazhong University of Science and Technology
2016-2024
Union Hospital
2024
Tongde Hospital of Zhejiang Province
2024
Background: The Covid-19 pandemic restricts children and adolescents from doing normal daily activities such as playing outdoors going to school. incidence prevalence of myopia have increased during the COVID-19 pandemic. aim this study was investigate evaluate impact home confinement on progression among in Chongqing, China. Methods: survey conducted by using stratified samplings. Samples were randomly selected 2019 National Student Physique Health Survey database, their visual function...
This study aimed to investigate the prevalence of depression and anxiety, associated factors, among Chinese children adolescents aged 8-18 years who attend primary or high school.A total 23 005 school students were recruited from February December, 2019 for this cross-sectional study. The questionnaire included demographic information, questions assessing suicidality, resilience, (Center Epidemiological Studies Depression Scale Children), anxiety (Screen Child Anxiety Related Disorders)....
The Insulin-like growth factor 2 mRNA binding protein (IGF2BP2) gene is closely associated with the diseases, fat deposition, and reproduction traits in animals. Investigations into relationship between IGF2BP2 polymorphism provide valuable breeding information for enhancing productivity economic gains pigeon. In this study, single nucleotide polymorphisms (SNPs) 13 exons 3' untranslated region (3'UTR) of 292 female pigeons Tianxiang 1 strain were detected through Sanger sequencing, their...
AIM: To assess the visual outcomes and corneal biomechanical properties of myopia patients between laser in situ keratomileusis (LASIK) LASIK combined with accelerated crosslinking (LASIK Xtra). METHODS: This prospective study analyzed 52 consecutive treated Xtra 45 LASIK. Only right eyes two groups were analyzed. The uncorrected distance acuity (UDVA), keratometry values, postoperative central thickness (CCT), demarcation line depth, compensated intraocular pressure (IOPcc),...
Purpose.: Recent studies have shown that a decrease of regulatory T (Treg) cells may contribute to the activity acute anterior uveitis (AAU) and ankylosing spondylitis (AS). A number immunogenetic factors including IL2RA, miR-27a, miR-182, FoxO1 are associated with Treg cell function. In this study, we investigated association between polymorphisms these genes AAU or without AS in Chinese Han population. Methods.: Using PCR-restricted fragment length polymorphism (RFLP) assay, two-stage...
Purpose: To investigate the efficacy and safety of saffron in treatment major depressive disorder (MDD) comparison to placebo synthetic antidepressants. Patients methods: We conducted a systematic search several electronic databases as well manual bibliographies relevant studies. included randomized controlled trials that investigated for treating MDD adults either or Primary outcome was change scores on symptoms from baseline. Secondary outcomes remission rate, response drop-out rate all...
Objectives To investigate myopia progression and associated factors of refractive status among children adolescents in Tibet Chongqing China during the COVID-19 pandemic. Methods A population-based cross-sectional study was conducted to compare rates high myopia, axial length (AL), spherical equivalent (SE), outdoor activity time, digital device use, frequency visual examinations for affected by 2021. Results total 2,303 students from 1,687 were examined. The overall prevalence these two...
Emerging evidence indicates that the transcription factor nuclear factor-E2-related 2 (Nrf2) plays an essential role in cellular defense against oxidative stress; its activation has been related to cytoprotection.Here, we investigated of Nrf2 improving efficacy methyl pyropheophorbide-amediated photodynamic therapy (Mppa-PDT) via downregulation Nrf2.Human ovarian cancer A2780 cells and SKOV3 were treated with Mppa-PDT siRNA transfection was performed inhibit Nrf2. After Mppa-PDT, cell...
Objective This study aims to determine whether the genetic polymorphisms of IL-12B gene is a susceptibility factor Ankylosing spondylitis (AS) in mainland Han Chinese population. Method Eight single-nucleotide (SNPs) (rs10045431, rs11167764, rs3212227, rs6556412, rs6556416, rs6871626, rs6887695 and rs7709212) were genotyped by iMLDR Assay technology 400 patients [96% (384/400) HLA-B27(+)] 395 geographically ethnically matched healthy controls The correlation between AS activity index...
Pilose antler polypeptides (PAP) have been reported to promote chondrocyte proliferation. However, the underlying mechanism remains unclear. The present study was investigate effects of PAP on proliferation chondrocytes and its mechanism.Chondrocytes isolated from knee Zealand white rabbits were cultured. second generation collected identified using safranin-O staining. divided into following 4 groups including serum-free, PAP, genistein (an inhibitor tyrosine kinases), plus group. Cell...
Summary Vogt–Koyanagi–Harada (VKH) disease is an autoimmune leading to visual impairment. Its pathogenic mechanisms remain poorly understood. Our purpose was investigate the distinctive protein and metabolic profiles of sweat in patients with VKH disease. In present study, proteomics metabolomics analysis performed on 60 samples (30 30 normal controls) using liquid chromatography tandem mass spectrometry. Parallel reaction monitoring (PRM) used validate results our omics analysis. total, we...
Abnormal development of central nervous system (CNS) caused by neural tube defects (NTDs) is not only remained the major contributor in prevalence stillbirths and neonatal deaths, but also represents a significant cause lifelong physical disability surviving infants. Ethionine non-proteinogenic amino acid antagonist methionine. Methionine cycle essential for elimination reactive oxygen species (ROS), while lysosomes are involved initiation autophagy. However, its role ethionine-induced cell...
Pelvic organ prolapses (POP) notably reduces the quality of life in elderly populations due to bladder and bowel dysfunction, incontinence, coital problems. Extracellular matrix (ECM) disorder is a pivotal event progression POP, but date, its specific underlying mechanism remains unclear. The ligaments patients with POP healthy controls were collected compare expression Homeobox11 (HOXA11) transforming growth factor β (TGF‑β1) via immunohistochemical analysis. HOXA11 TGF‑β1 overexpressed or...
Isolated ectopia lentis is usually autosomal dominant and commonly due to the mutations of FBN1 gene. We report on a family with lentis. The propositus 6‐year‐old boy bilateral superior‐temporal His echocardiogram was normal he did not meet revised Ghent criteria for Marfan syndrome. Molecular genetic testing revealed c.1948 C>T (p.Arg650Cys) in . mother has visual acuity 20/20 −4.50 right eye −2.50 left eye. She no evidence DNA analysis that she same mutation. Seven other maternal...