A5019116845- Ocular Diseases and Behçet’s Syndrome
- Cytomegalovirus and herpesvirus research
- Toxoplasma gondii Research Studies
- RNA modifications and cancer
- Retinal and Optic Conditions
- T-cell and Retrovirus Studies
- Child and Adolescent Psychosocial and Emotional Development
- Herpesvirus Infections and Treatments
- Virus-based gene therapy research
- Bladder and Urothelial Cancer Treatments
- Cancer, Lipids, and Metabolism
- Circular RNAs in diseases
- Suicide and Self-Harm Studies
- Endometriosis Research and Treatment
- Oral and Maxillofacial Pathology
- HIV Research and Treatment
- Neuroendocrine Tumor Research Advances
- Trace Elements in Health
- Psychosocial Factors Impacting Youth
- Retinal Diseases and Treatments
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- SARS-CoV-2 and COVID-19 Research
- Retinoids in leukemia and cellular processes
- Extracellular vesicles in disease
Tokyo Medical and Dental University
2023-2024
Qingdao University
2020-2024
Affiliated Hospital of Qingdao University
2020-2024
Chongqing Medical University
2023
Xian Central Hospital
2021
Government of Jilin Province
2019
Changhai Hospital
2019
Second Military Medical University
2019
This study aimed to investigate the prevalence of depression and anxiety, associated factors, among Chinese children adolescents aged 8-18 years who attend primary or high school.A total 23 005 school students were recruited from February December, 2019 for this cross-sectional study. The questionnaire included demographic information, questions assessing suicidality, resilience, (Center Epidemiological Studies Depression Scale Children), anxiety (Screen Child Anxiety Related Disorders)....
Abstract Background Carnitine palmitoyl transferase 1A (CPT1A), the key regulator of fatty acid oxidation, contributes to tumor metastasis and therapeutic resistance. We aimed identify its clinical significance as a biomarker for diagnosis prediction breast cancer. Methods Western blot, ELISA in silico analysis were used confirm CPT1A levels cancer cell lines, culture medium tissues. Four hundred thirty patients, 200 patients with benign disease, 400 healthy controls enrolled randomly...
Vaccination is a public health cornerstone that protects against numerous infectious diseases. Despite its benefits, immunization implications on ocular warrant thorough investigation, particularly in the context of vaccine-induced inflammation. This review aimed to elucidate complex interplay between vaccination and eye, focusing molecular immunological pathways implicated vaccine-associated adverse effects. Through an in-depth analysis recent advancements existing literature, we explored...
In aging societies, uveitis-a leading cause of vision loss due to ocular inflammation-is increasingly prevalent, especially among older people. This study aimed determine the trends and contributing factors herpetic uveitis in people, reflecting broader impact demographic shifts on health. A retrospective at Institute Science Tokyo reviewed cases patients aged ≥ 65 years between 2012 2022. Among 1095 diagnosed with uveitis, (5.9%) had herpesvirus predominantly manifesting as unilateral...
Human T-cell leukemia virus type 1 (HTLV-1), a that affects 5–10 million people globally, causes several diseases, including adult leukemia-lymphoma and HTLV-1-associated uveitis (HU). HU is prevalent in Japan often leads to secondary glaucoma, which serious complication. We investigated the efficacy of ripasudil, Rho-associated coiled coil-forming protein kinase inhibitor, alleviating changes human trabecular meshwork cells (hTM cells) infected with HTLV-1. HTLV-1-infected hTM were modeled...
Introduction: Hypohidrotic ectodermal dysplasia (HED) is a genetic disorder that influences structures of origin, such as teeth, hair, and sweat glands. Compared with autosomal recessive dominant modes inheritance, the X-linked HED (XLHED) characterized by Hypodontia/Oligodontia Absent/sparse Anhidrosis/hypohidrosis, characteristic facial features, most frequent its primary cause mutation ectodysplasin A (EDA) gene. This research aimed to expound clinical molecular features Chinese male...
Since the introduction of combination antiretroviral therapy (cART) in Japan 2008, spectrum ocular manifestations patients with human immunodeficiency virus (HIV) has changed. This study, conducted at Tokyo Medical and Dental University Hospital between January 2012 August 2023, aimed to understand epidemiology clinical features HIV during cART era. Of 218 diagnosed HIV, 23 (10.55%) exhibited manifestations; all were male, aged 32–73. The most prevalent complication was uveitis (60.67%)....
Abstract Purpose This study aims to investigate the variations in prevalence of depressive symptoms among Chinese children and adolescents with different lifestyles, including Internet use, breakfast, exercise, sleep homework, further explore impact gender on relationship between lifestyles symptoms. Methods The cross-sectional recruited school-based students (8–18 years) throughout Chongqing, China. Center for Epidemiological Studies Depression Scale Children (CES-DC) was utilized assess...
Background: Carnitine palmitoyl transferase 1A (CPT1A) is the rate-limiting enzyme of fatty acid oxidation. It overexpressed in advanced breast cancer and leads to poor survival. Here we aimed examine serum levels CPT1A a large-scale study develop as biomarker for early diagnosis cancer. Methods: An ELISA was conducted detect 432 patients, 200 patients with benign disease, 400 healthy controls training set test set. Receiver operating characteristic curves were generated, binary logistic...
目的： 探讨膀胱原发单纯性小细胞癌（small cell carcinoma，SmCC）的临床病理学特征和预后。 方法： 收集2005年1月至2019年4月青岛大学附属医院、海军第九七一医院及青岛市市立医院诊断膀胱原发单纯性SmCC 15例，采用HE、免疫组织化学染色进行组织形态学、免疫表型观察，并与同期诊断的28例浸润性高级别尿路上皮癌进行预后比较。 结果：...
Abstract Background: Currently, there is little information on the expression profiles of circRNAs in lens. βB2-crystallin (CRYBB2) an abundant protein mammalian lens, and its abnormal contributes to development cataract. This study aimed at exploring how Crybb2 knockout could modulate mouse Methods Results: We extracted total RNAs from lens wide-type (WT) -/- mice after depleted their rRNAs broken remaining RNAs, we reversely transcribed into cDNAand sequenced them. Furthermore, performed...