A5081312420- Angiogenesis and VEGF in Cancer
- Neurological Disorders and Treatments
- Alzheimer's disease research and treatments
- Cell Adhesion Molecules Research
- Colorectal Cancer Treatments and Studies
- Anesthesia and Pain Management
- Analytical Chemistry and Chromatography
- Neuroinflammation and Neurodegeneration Mechanisms
- S100 Proteins and Annexins
- Lung Cancer Treatments and Mutations
- Natural Antidiabetic Agents Studies
- Renal cell carcinoma treatment
- Cancer, Lipids, and Metabolism
- HER2/EGFR in Cancer Research
- Adipokines, Inflammation, and Metabolic Diseases
- Gastric Cancer Management and Outcomes
- Drug Transport and Resistance Mechanisms
- HIV Research and Treatment
- Analytical Methods in Pharmaceuticals
- Advanced Glycation End Products research
- Ginkgo biloba and Cashew Applications
- Nutrition and Health in Aging
- Inflammatory Biomarkers in Disease Prognosis
- Blood properties and coagulation
- Kruppel-like factors research
China Agricultural University
2014-2025
Shanghai Institute of Materia Medica
2024-2025
Chinese Academy of Sciences
2024-2025
Nanjing University of Chinese Medicine
2024-2025
Shanghai University of Traditional Chinese Medicine
2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2024
Boston Children's Hospital
2023
Harvard University
2023
Manchester Metropolitan University
2012-2022
Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș
2018-2021
Abstract Alzheimer’s disease (AD) increases dramatically in patients with ischaemic stroke. Monomeric C-reactive protein (mCRP) appears the ECM of tissue after stroke, associating microvasculature, neurons and AD-plaques, Aβ, also, being able to dissociate native-CRP into inflammatory, mCRP vivo . Here, injected hippocampal region mice was retained within retrosplenial tract dorsal 3rd ventrical surrounding major vessels. Mice developed behavioural/cognitive deficits 1 month, concomitant...
Background The purpose of this study was to examine whether very short duration, high intensity sprint interval training (SIT) leads loss body fat mass in association with improvements VO 2 max and fatty acid oxidation, assess the extent sex dimorphism these physiological responses. Methods A total 24 men 17 women (mean (SEM) age: 39 (±2) years; index 24.6 (0.6)) completed measurements maximal rate oxygen uptake (VO max) oxidation (FATmax). Body lean were measured by dual emission x-ray...
BACKGROUND The objective of this study was to determine the efficacy and safety locoregional therapy (LRT) combined with arsenic trioxide (As 2 O 3 ) treatment in primary hepatocellular carcinoma (HCC) patients. METHODS One hundred twenty‐five HCC patients were recruited for a randomized controlled study. Patients randomly divided into group A (n = 61) B 64). All received transarterial chemoembolization. Group given As at 10 mg/d 4 courses (21 days per course) 2‐week interval between...
Background Citicoline is one of the neuroprotective agents that have been used as a therapy in stroke patients. There limited published data describing mechanisms through which it acts. Methods We vitroangiogenesis assays: migration, proliferation, differentiation into tube-like structures Matrigel™ and spheroid development assays human brain microvessel endothelial cells (hCMEC/D3). Western blotting was performed on protein extraction from hCMEC/D3 stimulated with citicoline. An analysis...
Abstract Human immunodeficiency virus type-1 (HIV-1)-associated neurocognitive disorder (HAND) remains an important neurological manifestation that adversely affects a patient’s quality of life. HIV-1 matrix protein p17 (p17) has been detected in autoptic brain tissue HAND individuals who presented early with severe AIDS encephalopathy. We hypothesised the ability to misfold may result generation toxic assemblies and be relevant for pathogenesis. A multidisciplinary integrated approach...
Because of improving treatments and survival, 40% to 58% patients with bone metastases from nonsmall cell lung cancer (NSCLC) will suffer at least one skeletal-related event (SRE), affecting their quality life, but the natural history SRE is poorly understood. The study aimed examine factors involved in SRE-free survival (SRS) overall (OS) NSCLC metastases.This was a retrospective 211 metastasis treated Tumor Hospital Affiliated Harbin Medical University between January 2007 2012. OS SRS...
Monomeric C-reactive protein (mCRP) is now accepted as having a key role in modulating inflammation and particular, has been strongly associated with atherosclerotic arterial plaque progression instability neuroinflammation after stroke where build-up of the mCRP within brain parenchyma appears to be connected vascular damage, neurodegenerative pathophysiology possibly Alzheimer's Disease (AD) dementia. Here, using immunohistochemical analysis, we wanted confirm localization overall...
Diabetic retinopathy is the leading cause of blindness in industrialized world. Hyperglycaemia induces retinal hypoxia that upregulates a range vasoactive factors which may lead to macular oedema and/or angiogenesis and hence potentially sight threatening retinopathy. In this study, we have focused on association CD105 vascular endothelial growth factor (VEGF) with development progression diabetic by means quantifying their expression plasma vitreous patients. levels were quantified 38 type...
The enantioselective bioactivity against pathogens (Cercospora arachidicola, Fulvia fulva, and Phytophthora infestans) acute toxicity to Daphnia magna of the fungicide myclobutanil enantiomers were studied. (+)-enantiomer in an antimicrobial activity test was about 1.79-1.96 times more active than (-)-enantiomer. In assay, calculated 24-h LC50 values (-)-form, rac-form (+)-form 16.88, 13.17, 11.91 mg/L, 48-h 10.15, 9.24, 5.48 respectively, showing that (+)-myclobutanil toxic. Meanwhile,...
Objectives: In this study, we examined the possibility of using targeted antibodies and potential small molecular therapeutics (acetylcholine, nicotine tacrine) to block pro-inflammatory adhesion-related properties mCRP. Methods: We used three established models (platelet aggregation assay, endothelial leucocyte binding assay monocyte inflammation via ELISA Western blotting) assess these therapeutics. Results: The results study showed that induced (raised TNF-α) by mCRP was significantly...
Abstract Sodium butyrate (NaBu), a form of short-chain fatty acid (SCFA), acts classically as potent anti-angiogenic agent in tumour angiogenesis models, some authors demonstrated that low concentrations NaBu may contribute to healing tendon-bone injury part at least through promotion tissue remodelling. Here, we investigated the effects low-range using vitro and vivo assays primary outcome measure mechanisms which it acts. We NaBu, alone or perfused from UltraBraid+NaBu suture was...
Abstract We previously reported initial clinical results of post-transcriptional gene silencing BCL11A expression (NCT 03282656) reversing the fetal to adult hemoglobin switch. A goal this approach is increase (HbF) while coordinately reducing sickle (HbS) expression. The resulting combinatorial effect should prove effective in inhibiting HbS polymerization at lower physiologic oxygen values thereby mitigating disease complications. Here we report exploratory single-cell analysis patients...
<italic>Momordica charantia</italic>extracts protect against advanced glycation endproduct-induced anti-angiogenisis<italic>in vitro</italic>.
Adipose tissue and more specifically micro-fragmented adipose (MFAT) obtained from liposuction has recently been shown to possess interesting medicinal properties whereby its application supports pain reduction may enhance regeneration particularly in osteoarthritis. Here we have characterised samples of MFAT produced using the Lipogems® International Spa system eight volunteer individuals order understand critical biological mechanisms through which they act. A variation was found cluster...
Cardiovascular disease is prevalent in type 2 diabetics, and microalbuminuria associated with cardiovascular morbidity. We aimed to investigate the potential association between low-grade albuminuria arterial stiffness patients diabetes.Between 2009 2013, a retrospective study was performed 578 diabetes (339 male 239 female patients) normal urinary albumin-to-creatinine ratios (ACRs; <30 mg/g) from Fuzhou, China. Patients were stratified into tertiles based on ACR levels (lowest tertile, <...
Although epidemiologic studies suggest that dyslipidemia increases the risk of colorectal cancer (CRC), prognostic value blood lipid and apolipoprotein levels in CRC remains unclear. The aim present study was to investigate impact on prognosis patients with stage III high-risk II undergoing curative surgery. Preoperative total cholesterol, triglycerides (TG), high-density lipoprotein, low-density very-low-density A1 B (APO-B) surgery were evaluated. cut-off values these factors determined by...