A5038389607- Nutrition and Health in Aging
- Cardiovascular Health and Disease Prevention
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Diabetes and associated disorders
- RNA modifications and cancer
- Bone Metabolism and Diseases
- Nutritional Studies and Diet
- Bone health and treatments
- Adipose Tissue and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Bone health and osteoporosis research
- Pain Mechanisms and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Chronic Kidney Disease and Diabetes
- Meat and Animal Product Quality
- Diet and metabolism studies
- Bone and Joint Diseases
- Botulinum Toxin and Related Neurological Disorders
- Wound Healing and Treatments
- Immune Response and Inflammation
- Liver Disease Diagnosis and Treatment
- Blood Pressure and Hypertension Studies
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
First Affiliated Hospital of Fujian Medical University
2016-2025
Fujian Medical University
2016-2025
Jiangnan University
2022-2023
State Key Laboratory of Food Science and Technology
2022-2023
Fujian Institute of Microbiology
2019-2021
Diabetes mellitus (DM) and osteoporosis are two common diseases that may develop as a cause-and-effect relationship since the incidence of osteoporotic fractures is significantly increased in DM patients. However, pathophysiology diabetic yet to be clearly understood. Iron overload has been reported lead bone loss closely related osteoporosis. In this study, we hypothesized high glucose fat (HGHF) induce osteoblastic ferroptosis for pathogenesis explored possible molecular mechanisms behind....
This study aims to compare the predictive efficacy of different diagnostic criteria for sarcopenia in forecasting occurrence osteoporosis (OP) and fractures. Utilizing data from Global Health Data Exchange, burden musculoskeletal disorders (MSDs) was assessed through indicators including incidence, prevalence, disability-adjusted life years. Trends MSD were analyzed using Joinpoint regression model calculate average annual percentage change. A retrospective cohort conducted on clinical 8180...
Osteoporosis (OP) is a prevalent chronic bone metabolic disorder that affects the elderly population, leading to an increased susceptibility fragility. Despite extensive research on onset and progression of OP, precise mechanisms underlying this condition remain elusive. The m6A modification, form chemical RNA primarily regulates posttranscriptional processes, including stability, splicing, translation. Numerous studies have underscored crucial functions regulators in OP. This study aimed...
Abstract Aims Current hypertension guidelines fail to discriminate between fasting and postprandial blood pressure (BP) measurements. Meal ingestion often triggers a marked increase in splanchnic flow, potentially inducing sustained fall systolic BP of ≥20mmHg, termed hypotension (PPH). This study aimed evaluate responses 75g glucose drink its implications for detecting PPH community-dwelling adults. Methods A stratified multi-stage random sampling method was used obtain nationally...
The terrifying undiagnosed rate and high prevalence of diabetes have become a public emergency. A efficiency cost-effective early recognition method is urgently needed. We aimed to generate innovative, user-friendly nomograms that can be applied for screening in different ethnic groups China using the non-lab or noninvasive semi-lab data.This multicenter, multi-ethnic, population-based, cross-sectional study was conducted eight sites by enrolling subjects aged 20-70. Sociodemographic...
Irisin is a proteolytic product of the fibronectin type III domain‑containing protein 5. The aim present study was to verify whether irisin involved in pathogenesis diabetic mild cognitive impairment and elucidate associated mechanisms. Diabetic rats were divided into four groups: Control, Model, (overexpression irisin) Irisin‑short hairpin (sh)‑RNA (irisin interference). levels irisin, brain‑derived neurotrophic factor (BDNF), glycosylated hemoglobin A1c (GHbA1c) advanced glycated end...
To investigate the relationship between different body mass index (BMI) levels and vascular complications in type 2 diabetes mellitus patients.Data were collected from 3,224 individuals with (male/female: 1,635/1,589; age 61.31 ± 11.45 years), using a retrospective case study design. The association of BMI quintiles was assessed multiple logistic regression models adjusting for age, sex, duration, smoking status, drinking other confounders, those lowest quintile as reference group.With...
In this study, the effect of different temperatures (4 °C and 10 °C) on physicochemical properties surimi sol was investigated during various storage time (0–7 d). addition, water distribution, gel microstructure gels prepared from treated sol, both with without shearing, were analyzed. The results showed a continuous increase in strength indicating sol-gel transition occurred. Notably, there significant decrease (P < 0.05) protein solubility formation network structures, suggesting...
Metformin can prevent hyperglycaemia-induced osteoporosis and decrease the bone fracture rate, but mechanism has not been fully elucidated. To reveal by which metformin affects osteoporosis, we treat a mouse cell model with find that osteoblast mineralization increases PPARγ expression decreases. Single-cell mRNA sequencing analysis show is highly expressed in tissue of patients, highlights role osteoporosis. Furthermore, effector through prevents We further examine regulation regulates AMPK...
Abstract The aim of the present study was to explore influence tea consumption on diabetes mellitus in Chinese population. This multi-centre, cross-sectional conducted eight sites from south, east, north, west and middle regions China by enrolling 12 017 subjects aged 20–70 years. Socio-demographic general information collected a standardised questionnaire. A standard procedure used measure anthropometric characteristics obtain blood samples. diagnosis determined using 75-g oral glucose...
This study aimed to determine whether patients with type 2 diabetes and sarcopenia had a higher risk of infection.A cross-sectional follow-up were performed.A total 2562 enrolled assessed for body composition infection status. They classified into four groups according fat (BF) muscle mass index (ASMI): obese, sarcopenic, sarcopenic normal. Among these, 275 followed median period 1.84 years evaluate the relationship changes in skeletal status.The obese showed infection, an increase by 49.6%...
Objective. To investigate the association between sarcopenia and anemia 10-year cardiovascular disease risk in diabetic patients. Methods. A cross-sectional study was conducted involving 4673 hospitalized patients (2271 men 2402 women) with type 2 diabetes mellitus, an average age of <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M1"> <a:mn>60.66</a:mn> <a:mo>±</a:mo> <a:mn>11.93</a:mn> </a:math> years, whom 542 were followed up for a median follow-up period 24 months. All...
Summary Silver carp myofibrillar proteins (MP) with different moleculars states were constructed by the addition of NaCl and fracture degree muscle fibres. Results showed that salt‐dissolved MP (P+) under unfrozen oxidised state higher oxidation carbonyl (3.42 nmol mg −1 ) dityrosine contents (25.98 a.u.) ( P < 0.05) compared saltless‐polymeric (P) salt‐induced swelling (F+) due to salt broken After oxidative freeze–thaw process, P+ group also exhibited more cross‐linking as evidenced...
Cardiovascular disease is prevalent in type 2 diabetics, and microalbuminuria associated with cardiovascular morbidity. We aimed to investigate the potential association between low-grade albuminuria arterial stiffness patients diabetes.Between 2009 2013, a retrospective study was performed 578 diabetes (339 male 239 female patients) normal urinary albumin-to-creatinine ratios (ACRs; <30 mg/g) from Fuzhou, China. Patients were stratified into tertiles based on ACR levels (lowest tertile, <...