A5101711786- Pancreatic function and diabetes
- Nutrition and Health in Aging
- Metabolism, Diabetes, and Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Disease Prevention
- Diabetes Treatment and Management
- Diet, Metabolism, and Disease
- RNA modifications and cancer
- Cardiovascular Function and Risk Factors
- Liver Disease Diagnosis and Treatment
- Pain Mechanisms and Treatments
- Nutritional Studies and Diet
- Thyroid Disorders and Treatments
- Diabetes and associated disorders
- Bone Metabolism and Diseases
- Diabetic Foot Ulcer Assessment and Management
- Cardiovascular Disease and Adiposity
- Botulinum Toxin and Related Neurological Disorders
- Immune Response and Inflammation
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer-related molecular mechanisms research
- Traditional Chinese Medicine Studies
- Cancer-related gene regulation
- Peptidase Inhibition and Analysis
- Advanced Glycation End Products research
Fujian Medical University
2016-2025
First Affiliated Hospital of Fujian Medical University
2016-2025
Fujian Institute of Microbiology
2019-2021
Xuzhou Medical College
2010
Affiliated Hospital of Xuzhou Medical College
2010
Diabetes mellitus (DM) and osteoporosis are two common diseases that may develop as a cause-and-effect relationship since the incidence of osteoporotic fractures is significantly increased in DM patients. However, pathophysiology diabetic yet to be clearly understood. Iron overload has been reported lead bone loss closely related osteoporosis. In this study, we hypothesized high glucose fat (HGHF) induce osteoblastic ferroptosis for pathogenesis explored possible molecular mechanisms behind....
Anthropometric indices to obesity were evaluated as predictors of metabolic syndrome risk factors. Our purpose was explore an optimal or more reliable anthropometric indicator and cut-off points for on in Chinese adults.
This study aimed to determine whether a relationship exist between pre-therapy 25-hydroxyvitamin D levels and the remission/negative conversion rates of thyrotropin receptor antibody (TRAB) during treatment in patients with newly diagnosed Graves' disease (GD). 171 were included from Endocrinology Department First Affiliated Hospital Fujian Medical University March 2013 April 2016. Ninety-five them at our hospital but transferred local hospitals for treatment. Seventy-six followed treated...
Osteoporosis (OP) is a prevalent chronic bone metabolic disorder that affects the elderly population, leading to an increased susceptibility fragility. Despite extensive research on onset and progression of OP, precise mechanisms underlying this condition remain elusive. The m6A modification, form chemical RNA primarily regulates posttranscriptional processes, including stability, splicing, translation. Numerous studies have underscored crucial functions regulators in OP. This study aimed...
Immune imbalance is the core pathophysiological mechanism of deterioration β-cell function driven by lipid metabolism disorders. Toll-like receptor 4 (TLR4) inflammatory signaling a key pathway that mediates lipotoxic injury in β-cells, but underlying needs to be further elucidated. Transmembrane protein 24 (TMEM24) transporter regulates pulsatile insulin secretion, its pathophysiology lipotoxicity remains unclear. In this study, we investigate whether TLR4-mediated affected inhibition...
To investigate the relationship between different body mass index (BMI) levels and vascular complications in type 2 diabetes mellitus patients.Data were collected from 3,224 individuals with (male/female: 1,635/1,589; age 61.31 ± 11.45 years), using a retrospective case study design. The association of BMI quintiles was assessed multiple logistic regression models adjusting for age, sex, duration, smoking status, drinking other confounders, those lowest quintile as reference group.With...
To assess the relationship between type 2 diabetes mellitus onset age and vascular complications in China.A retrospective review of 3,568 patients with using a propensity score-matched (PSM) cohort analysis was carried out two different groups (age 40 60 years). These were then subdivided into groups, early-onset (EOD40 EOD60; before years, respectively) late-onset (LOD40 LOD60: after respectively). Macrovascular microvascular analyzed PSM.Patients categorized both disease (EOD) had higher...
Metformin can prevent hyperglycaemia-induced osteoporosis and decrease the bone fracture rate, but mechanism has not been fully elucidated. To reveal by which metformin affects osteoporosis, we treat a mouse cell model with find that osteoblast mineralization increases PPARγ expression decreases. Single-cell mRNA sequencing analysis show is highly expressed in tissue of patients, highlights role osteoporosis. Furthermore, effector through prevents We further examine regulation regulates AMPK...
This study aimed to determine whether patients with type 2 diabetes and sarcopenia had a higher risk of infection.A cross-sectional follow-up were performed.A total 2562 enrolled assessed for body composition infection status. They classified into four groups according fat (BF) muscle mass index (ASMI): obese, sarcopenic, sarcopenic normal. Among these, 275 followed median period 1.84 years evaluate the relationship changes in skeletal status.The obese showed infection, an increase by 49.6%...
Objective. To investigate the association between sarcopenia and anemia 10-year cardiovascular disease risk in diabetic patients. Methods. A cross-sectional study was conducted involving 4673 hospitalized patients (2271 men 2402 women) with type 2 diabetes mellitus, an average age of <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M1"> <a:mn>60.66</a:mn> <a:mo>±</a:mo> <a:mn>11.93</a:mn> </a:math> years, whom 542 were followed up for a median follow-up period 24 months. All...