This study aimed to determine whether a relationship exist between pre-therapy 25-hydroxyvitamin D levels and the remission/negative conversion rates of thyrotropin receptor antibody (TRAB) during treatment in patients with newly diagnosed Graves' disease (GD). 171 were included from Endocrinology Department First Affiliated Hospital Fujian Medical University March 2013 April 2016. Ninety-five them at our hospital but transferred local hospitals for treatment. Seventy-six followed treated...

Irisin is a proteolytic product of the fibronectin type III domain‑containing protein 5. The aim present study was to verify whether irisin involved in pathogenesis diabetic mild cognitive impairment and elucidate associated mechanisms. Diabetic rats were divided into four groups: Control, Model, (overexpression irisin) Irisin‑short hairpin (sh)‑RNA (irisin interference). levels irisin, brain‑derived neurotrophic factor (BDNF), glycosylated hemoglobin A1c (GHbA1c) advanced glycated end...

Recent studies have demonstrated the benefits of osteocalcin (OCN) on glucose homeostasis and metabolic dysregulation. However, its role in body composition vascular function remains unknown. This study was designed to examine changes parameters as well arterial stiffness after OCN treatment type 2 diabetic rats. Adult male Sprague Dawley (SD) rats were fed chow or high fat diet (HFD) for 8 weeks, then diabetes induced with an injection low-dose streptozotocin (STZ) treated daily...

To assess the relationship between type 2 diabetes mellitus onset age and vascular complications in China.A retrospective review of 3,568 patients with using a propensity score-matched (PSM) cohort analysis was carried out two different groups (age 40 60 years). These were then subdivided into groups, early-onset (EOD40 EOD60; before years, respectively) late-onset (LOD40 LOD60: after respectively). Macrovascular microvascular analyzed PSM.Patients categorized both disease (EOD) had higher...

This study aimed to determine whether patients with type 2 diabetes and sarcopenia had a higher risk of infection.A cross-sectional follow-up were performed.A total 2562 enrolled assessed for body composition infection status. They classified into four groups according fat (BF) muscle mass index (ASMI): obese, sarcopenic, sarcopenic normal. Among these, 275 followed median period 1.84 years evaluate the relationship changes in skeletal status.The obese showed infection, an increase by 49.6%...

Objective. To investigate the association between sarcopenia and anemia 10-year cardiovascular disease risk in diabetic patients. Methods. A cross-sectional study was conducted involving 4673 hospitalized patients (2271 men 2402 women) with type 2 diabetes mellitus, an average age of <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M1"> <a:mn>60.66</a:mn> <a:mo>±</a:mo> <a:mn>11.93</a:mn> </a:math> years, whom 542 were followed up for a median follow-up period 24 months. All...

Objective To identify independent risk factors for diabetic neuropathy (DN) in patients with type 2 diabetes mellitus (T2DM). Methods We retrospectively analyzed 376 T2DM at the First Affiliated Hospital of Fujian Medical University, China between January 2013 and October 2016. Multivariate logistic regression was used to explore potential progression DN T2DM. Effect sizes were estimated using odds ratios (ORs) 95% confidence intervals (CIs). Results The prevalence 43.1%. indicated that...

Cardiovascular disease is prevalent in type 2 diabetics, and microalbuminuria associated with cardiovascular morbidity. We aimed to investigate the potential association between low-grade albuminuria arterial stiffness patients diabetes.Between 2009 2013, a retrospective study was performed 578 diabetes (339 male 239 female patients) normal urinary albumin-to-creatinine ratios (ACRs; <30 mg/g) from Fuzhou, China. Patients were stratified into tertiles based on ACR levels (lowest tertile, <...

Osteocalcin (OCN) has been proved to be closely related with the development of type 2 diabetes mellitus (T2DM). We aimed study if OCN could improve disorder islet cell caused by lipotoxicity. Alizarin red staining was used investigate mineralization. Western blotting and ELISA methods were measure protein expression. Immunofluorescence nuclear transfer. High glucose high fat inhibited differentiation osteoblast precursors. Overexpression insulin receptor (InsROE) significantly promoted...

To investigate the correlation between vibration sensory threshold (VPT) and renal function, including glomerulus tubule, in patients with type 2 diabetes mellitus (T2DM).

Objectives. Hyponatremia is a common complication of diabetes. However, the relationship between serum sodium level and diabetic peripheral neuropathy (DPN) unknown. This study was aimed at investigating low DPN in Chinese patients with type 2 diabetes mellitus. Methods. A retrospective performed on 1928 2010 2018. The multivariate test used to analyze nerve conduction function. restricted cubic spline flexibly model visualize DPN, followed by logistic regression adjustment. Results. As...

<b>Aims:</b> Low-grade albuminuria (LGA) has been shown to be associated with increased risk for cardiovascular disease. Our study investigated the relationship between normal urinary albumin-to-creatinine ratios (UACRs) and subclinical left ventricular (LV) diastolic dysfunction remodeling in diabetics non-diabetics. <b>Methods:</b> A total of 888 diabetic 208 non-diabetic patients UACRs (< 30 mg/g) from Fuzhou, Fujian Province, China were examined. The subjects stratified into quartiles...

Objective This study aimed to investigate the effects of multimodal preemptive analgesia on postoperative gastrointestinal function and clinical outcomes in patients undergoing laparoscopic colorectal surgery. Methods prospective included a total 108 elective surgery from June 2019 2020. The were divided into control group according random number table method. Patients given flurbiprofen axetil oxycodone before skin incision combined with bilateral transverse abdominis plane block (TAPB)...

A cross-sectional analysis was performed to explore the relationship between regional body fat distribution and blood pressure in non-obese subjects with different status of pressure. Dual-energy X-ray absorptiometry measure mass. Obesity defined as present ≥25% males ≥35% females. The ratio leg mass total (L/T) decreased gradually while trunk (Tr/T) increased increasing for both genders (P < .01), which consistent change obese ones; low Tr/T + high L/T group better than that group,...

&lt;b&gt;&lt;i&gt;Introduction:&lt;/i&gt;&lt;/b&gt; Albuminuria is a risk factor for macro- and microvascular complications of type 2 diabetes (T2D).With an increasing trend normoalbuminuria, however, the predictors – estimated glomerular filtration rate (eGFR) urine albumin-to-creatinine ratio (UACR) which one better predictor vascular T2D not clear. &lt;b&gt;&lt;i&gt;Objective:&lt;/i&gt;&lt;/b&gt; This study aimed to compare impacts albuminuria eGFR on patients with associated micro-...

Introduction It’s not clear whether there are differences in musculoskeletal damage and body composition among different age groups of type 2 diabetes. Therefore, the purpose this study is to analyze difference between early-onset diabetes (EOT2D) non-early-onset (NOT2D) damage. Methods A total 964 patients with mellitus were selected by 1:1 propensity score matching, including 534 males 430 females, an average 52 ± 7 years course 10 8.5 years. Bone mineral density measured, combined...

Abstract Objective This study aimed to determine whether a relationship exist between pre-therapy 25-hydroxyvitamin D levels and the remission/negative conversion rates of thyrotropin receptor antibody (TRAB) during treatment in patients with newly diagnosed Graves' disease (GD). Methods 171 were included from Endocrinology Department First Affiliated Hospital Fujian Medical University March 2013 April 2016. Ninety-five them at our hospital but transferred local hospitals for treatment....

Background: Identifying β ‐cells dysregulation in type 2 diabetes mellitus (T2DM) is crucial. Weight fluctuations are frequently observed during treatment. However, the relationship between body composition changes and islet ‐cell function individuals with T2DM remains insufficiently investigated. Methods: This retrospective longitudinal study encompassed a cohort of 775 patients, who underwent measuring using dual‐energy X‐ray absorptiometry (DEXA) followed up for median 2.29 years. Key...