A5080864937- Corruption and Economic Development
- Corporate Finance and Governance
- Pancreatic function and diabetes
- Lung Cancer Diagnosis and Treatment
- Local Government Finance and Decentralization
- Breast Lesions and Carcinomas
- Medical Imaging Techniques and Applications
- China's Socioeconomic Reforms and Governance
- Diabetes and associated disorders
- Public Policy and Administration Research
- Diabetes Treatment and Management
- Galectins and Cancer Biology
- Prenatal Substance Exposure Effects
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Bone Tumor Diagnosis and Treatments
- Advanced Sensor and Control Systems
- Macrophage Migration Inhibitory Factor
- Wound Healing and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Cardiovascular Disease and Adiposity
- Ultrasound Imaging and Elastography
- Management and Organizational Studies
- Medical Imaging and Pathology Studies
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
Sun Yat-sen Memorial Hospital
2021-2025
Peking University People's Hospital
2010-2025
Peking University
2010-2025
Sun Yat-sen University
2018-2025
Shanghai Clinical Research Center
2025
First Affiliated Hospital of Fujian Medical University
2023
Fujian Medical University
2023
Beijing Normal University
2019
Chinese Academy of Medical Sciences & Peking Union Medical College
2018
Wenzhou Medical University
2017
DNA methylation is one of the epigenetic mechanisms that regulates gene expression, chromosome structure, and stability. Our objective was to determine whether system could be a target following in utero postnatal exposure human blood contaminants. Pregnant rats were dosed daily from gestation day 1 until 21 with 2 dose levels either organochlorine pesticides (OCP; 0.019 or 1.9 mg/kg/day), methylmercury chloride (MeHg; 0.02 polychlorinated biphenyls (PCBs; 0.011 1.1 mixture (Mix; 0.05, 5...
How do we characterize and explain the behavioral patterns of Chinese bureaucracy amid China’s great transformation over past three decades? The prevailing “tournament competition” model presented in literature emphasizes role incentive design to bureaucratic behaviors. We develop an alternative “muddling through”—characterized by a reactive response multiple pressures, constant readjustments focus on short-term gains—to intermediate government agencies. underlying logics that induce these...
Drawing on insights from recent economic theories of incomplete contracts, we develop a theoretical model authority relationships in the Chinese bureaucracy by conceptualizing allocation control rights goal setting, inspections, and provision incentives among principal, supervisor, agents. Variations these give rise to different modes governance entail distinct behavioral implications parties. The proposed provides unified framework set analytical concepts examine structures, varying...
Objectives Adiponectin is closely related to glucose metabolism and traditional diabetes risk factors (obesity, hypertension dyslipidaemia). We aimed explore the association between adiponectin levels newly diagnosed type 2 mellitus (T2DM) pre-diabetes in subgroups classified according T2DM factors. Setting Sun Yat-sen Memorial Hospital of University. Participants 3680 individuals (1753 men 1927 women) aged 18–70 years from Guangzhou Dongguan, China, were enrolled December 2018 October 2019....
Re-epithelialization constitutes a critical stage in the intricate process of wound healing, yet its mechanisms context diabetic wounds remain elusive. In this study, role mesenchymal-epithelial transition (MET) vis-à-vis epithelial-mesenchymal (EMT) keratinocytes re-epithelialization is investigated. The findings reveal an impediment MET process, rather than EMT, which significantly compromised wounds. Furthermore, Desmoplakin (DSP) gene expression, encoding key desmosome protein,...
The prevalence of early-onset type 2 diabetes (EOD) is rapidly increasing. This study intends to screen for early cardiovascular abnormalities in patients newly diagnosed with EOD and evaluate the risk across cluster phenotypes. A total 400 ≤ 40 years old were enrolled from START cohort (the Study diAgnosed eaRly onset diabeTes). Cluster classification was performed using K-means method based on age, BMI, HbA1c, HOMA2-β, HOMA2-IR, GAD antibodies. Echocardiography carotid ultrasound within 3...
Metformin can prevent hyperglycaemia-induced osteoporosis and decrease the bone fracture rate, but mechanism has not been fully elucidated. To reveal by which metformin affects osteoporosis, we treat a mouse cell model with find that osteoblast mineralization increases PPARγ expression decreases. Single-cell mRNA sequencing analysis show is highly expressed in tissue of patients, highlights role osteoporosis. Furthermore, effector through prevents We further examine regulation regulates AMPK...
The histologic difference between alcoholic cardiomyopathy (ACM) and idiopathic dilated (IDCM) is unclear. present study aimed to identify the quantitative pathologic features of ACM compared with IDCM.Specimens from 6 regions (anterior left ventricle [LV], lateral LV, inferior interventricular septum [IVS], anterior right [RV], RV) were sampled each explanted heart. Specimens 4 healthy donor hearts obtained as normal control. Tissues sectioned Masson trichrome stained. Histomorphometry was...
Diabetic kidney disease (DKD) is a kind of common microvascular complication diabetes. This study aims to explore the possible links between blood sugar level and albuminuria, providing exact cut point "risk threshold" for glucose with DKD.The relationship albuminuria was modeled using linear logistic regression in REACTION cohorts (N= 8932). Odds ratios (ORs) 95% confidence intervals (CIs) were calculated by model. Two-slope used simulate associations ACR.We found that increase ACR...
BackgroundMaturity-onset diabetes of the young (MODY) due to variants hepatocyte nuclear factor 1-beta (HNF1β) (MODY5) has not been well studied in Chinese population. This study aimed estimate its prevalence and evaluate application a clinical screening method (Faguer score) early-onset (EOD) patients. MethodsAmong 679 EOD patients clinically diagnosed with type 2 mellitus (age at diagnosis ≤40 years), exons HNF1β were sequenced. Functional impact rare was evaluated using dual-luciferase...
Maturity-onset diabetes of the young 4 (MODY4) is caused by mutations PDX1; its prevalence and clinical features are not well known.This study aimed to investigate characteristics MODY4 in Chinese people clinically diagnosed with early-onset type 2 (EOD), evaluate relationship between PDX1 genotype phenotype.The cohort consisted 679 patients EOD. were screened DNA sequencing, their pathogenicity was evaluated functional experiments American College Medical Genetics Genomics guidelines....
Researchers of the Chinese bureaucracy generally believe that policy promotion depends on power party committees because they have absolute authority in China. This intuitive argument, however, lacks support from rigorous empirical research and theoretical analyses. Through close observation Bureau Justice, this paper analyzes how differentiated affects organizational interaction triggers corresponding government behavior. The finds while functional bureaus could use professional to carry...
Objective: This study aimed to explore the association between risk of newly diagnosed type 2 diabetes and galectin-3 adiponectin investigate whether their joint action shows a favorable assessment performance. Methods: We conducted community-based in 135 patients with 270 age- sex-matched nondiabetic patients. Odds ratios 95% confidence intervals were determined using logistic regression analysis. Receiver operating characteristic curve, decision curve analysis calibration plot used...
Objective To explore the effects of day care ward nursing model in patients with lumpectomy breast. Methods A total 106 Breast Surgery or Day-care Unit at Second Affiliated Hospital Wenzhou Medical University were selected by random sampling from January to February 2016. The group surgery (day model) and hospitalization (routine inpatient included 53 respectively. This study compared hospital stay, medical expense, satisfaction their family members between two...
Based on the contingency theory, this study takes 380 listed companies in high-tech industry as research object and explores impact of internal pay gap corporate performance.At same time, paper also studies effect nature property rights relationship between performance.The results show that enterprises has an inverted U-shaped with enterprise performance, is, increases, it is beneficial to performance within a certain range.If exceeds range, increase will negatively affect enterprises.The...