A5103105879- Wound Healing and Treatments
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Diabetic Foot Ulcer Assessment and Management
- Body Composition Measurement Techniques
- Antimicrobial Peptides and Activities
- Signaling Pathways in Disease
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Cancer-related gene regulation
- Circular RNAs in diseases
- Protease and Inhibitor Mechanisms
- RNA modifications and cancer
Sun Yat-sen Memorial Hospital
2021-2025
Sun Yat-sen University
2021-2025
First Affiliated Hospital of Jinan University
2024-2025
Shanghai Clinical Research Center
2025
Fourth Affiliated Hospital of Guangxi Medical University
2024
Introduction: Hypertension is a global health concern and leading risk factor for cardiovascular diseases. Central obesity, marked by abdominal fat, more strongly linked to hypertension than general obesity. Traditional metrics like Body Mass Index (BMI) overlook fat distribution. This study examines the association between Roundness (BRI) Z-score, novel central obesity measure, prevalence in China's middle-aged older adults. Methods: Utilizing data from China Health Retirement Longitudinal...
Re-epithelialization constitutes a critical stage in the intricate process of wound healing, yet its mechanisms context diabetic wounds remain elusive. In this study, role mesenchymal-epithelial transition (MET) vis-à-vis epithelial-mesenchymal (EMT) keratinocytes re-epithelialization is investigated. The findings reveal an impediment MET process, rather than EMT, which significantly compromised wounds. Furthermore, Desmoplakin (DSP) gene expression, encoding key desmosome protein,...
Background Cell division cycle protein 45 (CDC45) has been demonstrated to play vital roles in the progression of various malignancies. However, clinical significance CDC45 gastric cancer (GC) remains unreported. Method In this study, we employed TCGA database and & GTEx dataset compare mRNA expression levels between tissues adjacent or normal ( p < 0.05 was considered statistically significant), which further validated multiple datasets including GSE13911 , GSE29272 GSE118916...
Diabetic liver injury is a serious complication due to the lack of effective treatments and unclear pathogenesis. Ferroptosis, form cell death involving reactive oxygen species (ROS)-dependent lipid peroxidation (LPO), closely linked autophagy diabetic complications. Therefore, this study aimed at investigating role in regulating ferroptosis by modulating degradation acyl-CoA synthetase long-chain family member 4 (ACSL4) hepatocytes its potential impact on injury.