A5101597583- Inflammasome and immune disorders
- Wnt/β-catenin signaling in development and cancer
- Cell Adhesion Molecules Research
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- TGF-β signaling in diseases
- Cancer-related molecular mechanisms research
- Kawasaki Disease and Coronary Complications
- Mosquito-borne diseases and control
- interferon and immune responses
- Renal Diseases and Glomerulopathies
- Virology and Viral Diseases
- Cancer Genomics and Diagnostics
- Ginseng Biological Effects and Applications
- Gout, Hyperuricemia, Uric Acid
- Gut microbiota and health
- Hepatitis B Virus Studies
- Toxoplasma gondii Research Studies
- Acute Myeloid Leukemia Research
- Natural product bioactivities and synthesis
- Hepatitis C virus research
- Circular RNAs in diseases
- Microtubule and mitosis dynamics
- Endoplasmic Reticulum Stress and Disease
- Histone Deacetylase Inhibitors Research
Guangxi University
2025
University of Chinese Academy of Sciences
2009-2025
Tsinghua University
2017-2025
Zhuhai People's Hospital
2024
Jinan University
2017-2024
Hangzhou Medical College
2024
Zhejiang Provincial People's Hospital
2024
Xuzhou Medical College
2016-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Chinese Academy of Sciences
2005-2022
Objective: Long noncoding RNA growth arrest-specific transcript 5 (lncRNA GAS5) is involved in various kinds of cancer. However, the role lncGAS5 development ovarian cancer remains unclear. In present study, we explored cellular mechanism and clinical value lncRNA GAS5 Methods: Quantitative real-time PCR was used to detect mRNA level 20 tissues. The effect on cell proliferation performed using CCK-8 assay. Cell apoptosis evaluated by flow cytometry. Western blotting protein potential target....
Abstract The NLR family, pyrin domain-containing 3 (NLRP3) inflammasome is critical for caspase-1 activation and the proteolytic processing of pro–IL-1β. However, mechanism that regulates NLRP3 remains unclear. In this paper, we demonstrate tripartite-motif protein 30 (TRIM30) negatively activation. After stimulation with ATP, an agonist inflammasome, knockdown TRIM30 enhanced increased production IL-1β in both J774 cells bone marrow-derived macrophages. Similarly triggered by other...
Gut microbiota plays an important role in metabolic homeostasis. Previous studies demonstrated that ginsenoside Rb1 might improve obesity-induced disorders through regulating glucose and lipid metabolism the liver adipose tissues. Due to low bioavailability enrichment intestinal tract of Rb1, we hypothesized modulation gut account for its pharmacological effects as well. Here, show oral administration significantly decreased serum LDL-c, TG, insulin, insulin resistance index (HOMA-IR) mice...
Background/Objectives: Approved mRNA vaccines commonly use sequences modified with pseudouridine to enhance translation efficiency and stability. However, this modification can result in ribosomal frameshifts, reduced immunogenicity, higher production costs. This study aimed explore the potential of unmodified for varicella-zoster virus (VZV) evaluate whether codon optimization could overcome limitations modification. Methods: We utilized artificial intelligence (AI) design several gE VZV,...
Interferon regulatory factor 7 (IRF7)-mediated type I interferon antiviral response is crucial for regulating the host following viral infection in chickens. Infectious bursal disease virus (IBDV) a double-stranded RNA that induces immune suppression and high mortality rates chickens aged 3-6 weeks. Previous studies have shown IBDV antagonizes production to facilitate replication cell, IRF7 signaling might play an important role. However, underlying mechanisms enable block pathway remain...
Abstract The RNA-binding protein dyskerin, encoded by the DKC1 gene, functions as a core component of telomerase holoenzyme well ribonuclear complexes involved in RNA processing and ribosome biogenesis. diverse roles dyskerin across many facets biology implicate its potential contribution to malignancy. In this study, we examined expression function neuroblastoma. We show that mRNA levels were elevated relative normal cells panel 15 neuroblastoma cell lines, where both N-Myc c-Myc directly...
Highlights•Chronic stress causes chromatin misalignment and impaired colon epithelium homeostasis•Glucocorticoid receptor programs transcriptional changes via loops•Stress-circadian crosstalk via- Ikzf3-Nr1d1 suggests translational potentialSummaryStress-elevated glucocorticoids cause circadian disturbances gut-brain axis (GBA) disorders, including irritable bowel syndrome (IBS). We hypothesized that the glucocorticoid (GR/NR3C1) might in epithelium. observed significantly decreased core...
Radix notoginseng, the root of Panax notoginseng (Burk.) F. H. Chen, has been widely used in traditional Chinese medicine. Its main components, saponins, have reported to many pharmacological activities. To test general assumption that herbs a single species planted and harvested from location are uniform chemical genetic makeup, analysis DNA fingerprinting were carried out. High-performance TLC together with HPLC analyze 17 randomly sampled 3-year-old roots farm for presence six saponins....
Abstract Dynein‐mediated autophagosome ( AP ) trafficking was recently demonstrated to contribute the formation of autophagolysosomes APL s) and autophagic flux process in coronary arterial myocytes CAM s). However, it remains unknown how function dynein as a motor protein for is regulated under physiological pathological conditions. The present study tested whether dynein‐mediated autophagy maturation by redox signalling associated with lysosomal Ca 2+ release machinery. In primary cultures...
Lung cancer is one of the most fatal cancers due to its high metastatic rate. Traditional Chinese medicine has been used in patients for decades improve quality life and prolong survival time. The present study a novel Qiyusanlong (QYSL) decoction composed 10 kinds including astragalus membranaceus (Huangqi), polygonatumod oratum (yuzu), scolopendra (tianlong), pberetima (dilong), solanum nigrum (longkui), herbahedyotis (baihushecao), semen coicis (yiyiren), euphorbia helioscopia (zeqi),...
Abstract Oxytocin receptor (OXTR) is involved in social behaviors, thermoregulation, and milk ejection, yet little known about its role breast cancer. To investigate the of OXTR mammary gland development tumorigenesis, a transgenic mouse model overexpression ( ++ Oxtr ) was used. Overexpression OXTR-induced progressive hyperplasia, unexpected production, tumorigenesis females. tumors showed ERBB2 upregulation mixed histological subtypes with predomination papillary medullary carcinomas. led...
Non-small-cell lung cancer (NSCLC) is the leading global cause of cancer-related death. Due to lack reliable diagnostic or prognostic biomarkers, prognosis NSCLC remains poor. Consequently, there an urgent need explore mechanisms underlying this condition in order identify effective biomarkers. G-protein-signaling modulator 2 (GPSM2) widely recognized as a determinant mitotic spindle orientation. However, its role cancer, especially NSCLC, uncertain. In study, we found that GPSM2 was...
Acute myeloid leukemia (AML) is a highly heterogeneous disease. MicroRNAs function as important biomarkers in the clinical prognosis of AML. This study identified miR-425 prognostic factor AML by screening TCGA dataset. A total 162 patients with were enrolled for and divided into chemotherapy allogeneic hematopoietic stem cell transplantation (allo-HSCT) groups. In group, high expression had significantly longer overall survival (OS) event-free (EFS) compared low expression. multivariate...
Abstract Methicillin resistant Staphylococcus aureus (MRSA) is a major human pathogen, which causes superficial to lethal clinical infections. Neutrophils are the most abundant leukocytes in blood and first defense mechanism against S . Here we show taphylococcal uperantigen- L ike protein 11 (SSL11) from MRSA USA300_FPR3757 mediated differentiated neutrophil-like cells (dHL60) motility arrest by inducing cell adhesion “locking” stage, without oxidative burst. Pre-incubation of SSL11 with...