A5086335546- Chronic Obstructive Pulmonary Disease (COPD) Research
- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Analysis
- Ginseng Biological Effects and Applications
- Genomics, phytochemicals, and oxidative stress
- Cancer-related molecular mechanisms research
- Inflammation biomarkers and pathways
- Cancer Mechanisms and Therapy
- Pediatric health and respiratory diseases
- Traditional Chinese Medicine Studies
- Gut microbiota and health
- Natural product bioactivities and synthesis
- Autophagy in Disease and Therapy
- Drug Transport and Resistance Mechanisms
- Pharmacological Effects of Natural Compounds
- Inhalation and Respiratory Drug Delivery
- Plant-based Medicinal Research
- Glutathione Transferases and Polymorphisms
- Signaling Pathways in Disease
- Medical Research and Treatments
- Medicinal Plant Pharmacodynamics Research
- Cancer, Lipids, and Metabolism
- Healthcare and Venom Research
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
Anhui University of Traditional Chinese Medicine
2016-2025
Chinese Center For Disease Control and Prevention
2024
Anhui Provincial Department of Education
2023
Anhui University
2018
Shandong Academy of Chinese Medicine
2017
State Administration of Traditional Chinese Medicine of the People's Republic of China
2015
Chronic obstructive pulmonary disease (COPD), a prevalent, progressive respiratory disease, has become the third leading cause of death globally. Increasing evidence suggests that intestinal and microbiota dysbiosis is associated with COPD. Researchers have shown T helper (Th) 17/regulatory (Treg) imbalance involved in Qibai Pingfei Capsule (QBPF) traditional Chinese medicine used to treat COPD clinically China. However, effects QBPF intervention on Th17/Treg balance gut lung are still...
Qi-Yu-San-Long decoction (QYSLD), a traditional Chinese medicine (TCM) prescription, consisting of ten types herbal which has significant clinical efficacy in the treatment non-small cell lung cancer (NSCLC). However, bioactive ingredients QYSLD remain unclear, due to their "multi-ingredients" and "multi-targets" features. This study aimed construct spectrum-effect correlation analysis model screen potential active components QYSLD. A fingerprint method based on ultra-high performance liquid...
Chronic obstructive pulmonary disease (COPD) exacerbations accelerate loss of lung function and increased mortality. The complex nature COPD presents challenges in accurately predicting understanding frequent exacerbations. present study aimed to assess the metabolic characteristics exacerbation (COPD‑FE) phenotype, identify potential biomarkers associated with COPD‑FE risk evaluate underlying pathogenic mechanisms. An internal cohort 30 stable patients was recruited. A widely targeted...
In this work, an untargeted metabolomic method based on ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS) in MS E (E represents collision energy) mode was exploited to determine the dynamic metabolic alterations plasma of male C57BL/6 mice during onset and development lung carcinoma. Plasma samples were collected from control model (male experimentally inoculated with Lewis carcinoma cells) at 7 14 days post-inoculation (DPI). As a...
Arisaema heterophyllum Blume (AhBl) is one of the valued medicinal plants. However, its genetic information limited, which impedes further studies this valuable resource. To investigate genes involved in isoflavonoid biosynthesis, we deeply performed transcriptome sequencing for AhBl. An average 10.98 Gb clean reads were obtained based on root, tuber and leaf tissues, 109,937 unigenes yielded after de novo assembly. In total, 72,287 those annotated at least public database. The numbers...
Lung cancer is one of the most fatal cancers due to its high metastatic rate. Traditional Chinese medicine has been used in patients for decades improve quality life and prolong survival time. The present study a novel Qiyusanlong (QYSL) decoction composed 10 kinds including astragalus membranaceus (Huangqi), polygonatumod oratum (yuzu), scolopendra (tianlong), pberetima (dilong), solanum nigrum (longkui), herbahedyotis (baihushecao), semen coicis (yiyiren), euphorbia helioscopia (zeqi),...
Abstract Background Pingchuanning decoction is a well‐known traditional Chinese medicine for the treatment of airway inflammatory diseases, including asthma. However, potential mechanism by which contributes to amelioration inflammation remains unknown. Methods A rat model asthma was well established inducing ovalbumin. Lipopolysaccharide‐stimulated tracheal epithelial (RTE) cells were used as cellular model. Lung histopathology and goblet cell hyperplasia assessed hematoxylin‐eosin (HE)...
Multidrug resistance-associated protein 1 (MRP1), a member of the ATP-binding cassette (ABC) superfamily transporters, plays an important role in normal lung physiology by protecting cells against oxidative stress and toxic xenobiotics. The present study investigates effects allyl isothiocyanate (AITC) on MRP1 mRNA expression transporter activity immortalised human bronchial epithelial cell line 16HBE14o-. 16HBE14o- that were treated with analysed real-time PCR assay Western blotting....
To evaluate the effect of Liuweibuqi capsules on chronic obstructive pulmonary disease (COPD) through JAK/STAT pathway.Lung function was measured with a spirometer. Changes in lung histology were observed using H&E staining. Cigarette smoke extract combined lipopolysaccharide (CSE+LPS) used to establish cellular COPD model. Cytokine levels determined ELISA, and changes pathway evaluated western blotting. The CCK8 method flow cytometry measure cell viability apoptosis, respectively.Liuweibuqi...
Multidrug resistance-associated protein 1 (MRP1) plays a protective role in the etiology and progression of chronic obstructive pulmonary disease (COPD) which results from oxidative stress inflammation lung injury. The lower functional MRP1 activity is related to COPD development. Our previous study showed that Allyl isothiocyanate (AITC) induced expression dose-dependent manner. However, signaling pathway contributes upregulation by AITC unclear. In this study, specific inhibitors were used...
Qi-Yu-San-Long decoction (QYSLD) is a traditional Chinese medicine that has been clinically used in the treatment of non-small-cell lung cancer (NSCLC) for more than 20 years. However, to date, metabolic-related studies on QYSLD have not performed. In this study, post-targeted screening strategy based ultra-performance liquid chromatography coupled with quadrupole time-of-flight full information tandem mass spectrometry (UPLC-QTOF-MSE) was developed identify QYSLD-related xenobiotics rat...
Metabolism is undoubtedly significantly correlated with the efficacy and safety of traditional Chinese medicine. In clinic, Qi-Yu-San-Long decoction (QYSLD) has achieved good results in treatment non-small-cell lung cancer (NSCLC). Nevertheless, a detailed understanding compounds (prototypes metabolites) QYSLD its dynamic metabolic profile plasma not been revealed.In this study, rapid sensitive method based on ultra-performance liquid chromatography-quadrupole time-of-flight tandem mass...