A5056369207- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- MicroRNA in disease regulation
- Autoimmune and Inflammatory Disorders Research
- COVID-19 Clinical Research Studies
- Adolescent and Pediatric Healthcare
- CNS Lymphoma Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Bioactive Compounds and Antitumor Agents
- Cell death mechanisms and regulation
- Cerebrovascular and Carotid Artery Diseases
- Synthesis and biological activity
- Integrated Circuits and Semiconductor Failure Analysis
- RNA Interference and Gene Delivery
- Metal complexes synthesis and properties
- T-cell and Retrovirus Studies
- NF-κB Signaling Pathways
- Silicon Carbide Semiconductor Technologies
Nantong University
2025
Xuzhou Medical College
2015-2024
Tongji Hospital
2020-2024
Fujian Provincial Cancer Hospital
2024
Fujian Medical University
2024
Huazhong University of Science and Technology
2020-2024
Lishui University
2023
The First Hospital of Changsha
2021
Shandong University
2012-2019
Soochow University
2009-2018
Abstract Purpose Anti‐CD19 chimeric antigen receptor T (CAR‐T) cell therapy has demonstrated remarkable efficacy for refractory and relapsed diffuse large B lymphoma (R/R DLBCL). However, this failed in nearly 25% patients mainly due to loss. The authors performed a phase Ⅱ trial by coadministration of anti‐CD19 anti‐CD20 CAR‐T cells treatment R/R DLBCL evaluated its toxicity. Methods Totally 21 with were enrolled study. conditioned fludarabine cyclophosphamide before the infusion cells....
CFLARL, also known as c-FLIPL, is a critical anti-apoptotic protein that inhibits activation of caspase 8 in mammalian cells. Previous studies have shown arginine 122 CFLARL can be mono-methylated. However, the precise role methyltransferase remains unknown. PRMT5 and PRMT1, which are important members PRMT family, catalyze transfer methyl groups to substrate proteins. monomethylate or symmetrically dimethylate residues, while PRMT1 asymmetrically residues.Lung cancer cells were cultured...
The stochastic inversion method using logging data as conditional and seismic constraint has a higher vertical resolution than the conventional deterministic method. However, it remains challenging to reduce randomness of prior obtained through random simulation techniques enhance its accuracy. To address this, we propose based on compressed sensing frequency-division waveform indication prior. This fully considers geophysical mapping relationship between observed parameters be inverted...
Volcanic mounds and carbonate buildups share similar geometries, making their differentiation in seismic data a significant challenge. This challenge is further compounded complex composed of both multi-stage developed igneous rocks biogenic carbonates. To address this gap, study investigates mixed carbonate-igneous buildup at the central Baiyun Sag northern South China Sea. By analyzing lithofacies carbonates rocks, morphological features spatial distribution patterns corresponding to these...
Background Carbohydrate antigen 125 (CA125) is one of the most commonly used tumor biomarker for evaluating prognosis solid neoplasms. It has been reported that serum CA125 correlated with non-Hodgkin’s lymphoma. The objective this study to explore clinical value in diffuse large B-cell lymphoma (DLBCL). Methods We retrospectively analyzed and pathological data a cohort 315 newly diagnosed patients DLBCL. In our case, correlations between clinicopathological parameters were analyzed....
PS-341 (bortezomib), a proteasome inhibitor, has been approved for the treatment of multiple myeloma. Our previous work shown that induces death receptor 5 (DR5)-dependent apoptosis and enhances TNF-related apoptosis-inducing ligand-induced in human non-small cell lung cancer cells. However, definite mechanism remains undefined. In present study, we reveal PKCδ RSK2 mediate PS-341-induced DR5 upregulation, involving coactivation endoplasmic reticulum (ER) stress. We discovered activated ER...
Treatment of N,N-bis(diphenylphosphanylmethyl)-3-aminopyridine (3-bdppmapy) with AgX (X = Br, I, CN, SCN, dicyanamide (dca)) under different reaction conditions afforded seven mononuclear, dinuclear, and polymeric coordination complexes including [Ag4I4(3-bdppmapy)2]n (1), [Ag2I2(3-bdppmapy)3]·CH3OH (2·CH3OH), [Ag2Br(3-bdppmapy)3]Br·4CH3OH (3·4CH3OH), [Ag4(CN)4(3-bdppmapy)3]·2CH3OH (4·2CH3OH), [Ag(3-bdppmapy)2]SCN (5), [Ag(3-bdppmapy)2](dca) (6), {[Ag4(dca)4(3-bdppmapy)2]·4DMF}n (7)....
There is currently a pervasive prevalence of cardiovascular disease (CVD) risk worldwide and an inadequate amount action being taken to promote healthy lifestyle habits. The perception attitude (RPA) framework, which classifies individuals based on their efficacy belief, enables us predict preventive behaviors. We applied the RPA framework analyze CVD prevention behaviors among Chinese adults extended its application objective risk.
Abstract The aim of this study was to evaluate the role NLRP3 inflammasome on BU/CY-induced liver inflammation in mice after HSCT. HSCT model established through infusion 5 × 10 6 bone marrow mononuclear cells conditioned with BU/CY. On day 7, 14, 21 and 28 HSCT, were sacrificed for analysis inflammation, cytokine secretion, expression caspase-1 activation as well release ATP high-mobility group protein B1 (HMGB1). Furthermore, selective inhibitor (BAY 11-7082) administrated into its effects...
Objectives In December 2019, coronavirus disease 2019 (COVID-19) emerged in Wuhan City and rapidly spread across the world. The clinical characteristics of affected patients different regions populations may differ. Thus, this study aimed to identify provide an insight about prevention treatment COVID-19. Methods Data on demographic findings admitted at First Hospital Changsha from January 1, 2020 February 10, were assessed. Results study, there 8 (3.8%) asymptomatic, 21 (10.0%) mild upper...
Acute myeloid leukemia (AML) is a highly heterogeneous disease. MicroRNAs function as important biomarkers in the clinical prognosis of AML. This study identified miR-425 prognostic factor AML by screening TCGA dataset. A total 162 patients with were enrolled for and divided into chemotherapy allogeneic hematopoietic stem cell transplantation (allo-HSCT) groups. In group, high expression had significantly longer overall survival (OS) event-free (EFS) compared low expression. multivariate...
Despite advancement in the treatment of diffuse large B-cell lymphoma (DLBCL), many patients tend to relapse or become refractory after initial therapy.Therefore, it is essential identify novel therapeutic targets and drugs, understand molecular pathogenesis mechanism DLBCL, find ways prevent treat relapsed DLBCL.BIX-01294 a small molecule compound that specifically inhibits EHMT2 activity.In this study, we demonstrate BIX-01294 triggered inhibition human DLBCL cell proliferation, lead G1...
Background:: Although immunotherapies have greatly improved diffuse large B-cell lymphoma (DLBCL) prognosis, a proportion of patients remain to be relapsed or refractory. Therefore, the identification novel therapeutic targets and drugs is urgently required. Inhibition bromodomain extra-terminal (BET) proteins has been promising strategy for various haematologic cancers. CPI-0610 potent selective BET inhibitor. The effects in DLBCL cells not reported yet. Aims:: aim this study was assess its...
Abstract Natural chalcones have been proved to inhibit cancer cells with therapeutic potential, but the underlying molecular mechanism is still largely unexplored. Here, we identified a novel chalcone, 2′‐hydroxy‐4′,5′‐dimethoxychalcone (HDMC) and demonstrated that HDMC induced apoptosis in various nonsmall cell lung cells. Further study showed elevated cellular reactive oxygen species (ROS) levels, thus inducing expressions of ATF4 C/EBP homologous protein (CHOP). Then, death receptor 5...
Abstract Acute myeloid leukemia (AML) is a heterogeneous disease with unfavorable outcomes. MicroRNAs (miRNAs) are important regulators and prognostic factors involved in AML. To determine the clinical role of miR‐338 AML, total 164 adults de novo AML were collected. These patients classified into chemotherapy group an allogeneic hematopoietic stem cell transplantation (allo‐HSCT) according to treatment, then each was divided two subgroups based on median expression values. We found that...
Cladribine is a purine nucleoside analog used to treat B-cell chronic lymphocytic leukemia and hairy cell leukemia, also functions as an inhibitor of DNA synthesis block the repair damaged DNA.The therapeutic role cladribine against diffuse large lymphoma cells (DLBCL) still undefined.In present study, we demonstrated that inhibited proliferation induced G1 phase arrest in human DLBCL cells.Furthermore, showed apoptosis by decreasing expression c-FLIPL increasing DR4 cleaved form...