A5074529705- Immune cells in cancer
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Immune Cell Function and Interaction
- interferon and immune responses
- Phagocytosis and Immune Regulation
- Extracellular vesicles in disease
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Immune responses and vaccinations
- Endoplasmic Reticulum Stress and Disease
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Quantum Dots Synthesis And Properties
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Advanced Proteomics Techniques and Applications
- Protein Degradation and Inhibitors
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Microencapsulation and Drying Processes
- Histone Deacetylase Inhibitors Research
- Microbial Inactivation Methods
- DNA Repair Mechanisms
- RNA Research and Splicing
Jilin Medical University
2012-2024
Jilin University
2015-2024
Shanxi University
2024
Southwest University of Science and Technology
2024
Jiamusi University
2022-2024
China United Network Communications Group (China)
2023
Xuzhou Medical College
2015-2023
First Affiliated Hospital of GuangXi Medical University
2021-2023
Guangxi Medical University
2021-2023
Hangzhou Medical College
2021-2022
The microglia cell transfer has been shown to play a protective role in ischemic stroke. Microglia cells may this nerve-protective via the promotion of angiogenesis. However, underlying mechanisms are largely unknown and need further investigation.The aim study was investigate pro-angiogenesis effects unpolarized, interleukin-4 (IL-4)-polarized or lipopolysaccharide (LPS)-polarized BV2 both vivo vitro. We also investigated potential these effects.BV2 were polarized using phosphate-buffered...
Multifunctional nanoparticles (NPs) have great potential for multimodal cancer imaging and effective therapy. We developed multifunctional NPs (GNR@SiO2@QDs) by incorporating gold nanorods (GNRs) CdSe/ZnS quantum dots (QDs) into silica. Folic acid (FA) as a targeting ligand was covalently conjugated on the surfaces of GNR@SiO2@QDs with silane coupling agent. Cell viability assay showed that these had low cytotoxicity. And confocal fluorescence images illustrated they could selectively target...
Abstract Background Cancer‐associated cachexia (CAC) is a debilitating syndrome associated with poor quality of life and reduced expectancy cancer patients. CAC characterized by unintended body weight reduction due to muscle adipose tissue loss. A major hallmark systemic inflammation. Several non‐steroidal anti‐inflammatory drugs (NSAIDs) have been suggested for treatment, yet no single medication has proven reliable. R‐ketorolac (RK) the R‐enantiomer commonly used NSAID. The effect RK on...
It has been shown that drug resistance is extremely common in hepatocellular carcinoma (HCC) and one of the major problems HCC chemotherapy. However, detailed mechanisms remain largely unknown. We have previously endoplasmic reticulum (ER) stress involved tumorigenesis HCC. Here, we demonstrated unfolded protein response (UPR) inhibits cisplatin-induced cell apoptosis. In cells, cisplatin treatment triggers UPR, which subsequently Importantly, mild ER precondition suppresses sensitivity...
Keloid is a fibrous benign tumor of the skin caused by increased fibroblast proliferation and overproduction extracellular matrix (ECM) in dermis. Several miRNAs exhibit critical roles regulating keloid development. This study aimed to investigate effects mechanisms miR-203 fibroblasts. The expression was detected qRT-PCR; cell viability measured MTT assay; BrdU invasion Transwell protein Western blot; target relationship between mRNA dual-luciferase assay. We found that significantly...
Cancer cells are relatively resistant to endoplasmic reticulum (ER) stress-induced apoptosis. However, the underlying mechanisms remain largely unclear. We observed that microRNAs miR-221/222 associated with apoptosis regulation under ER stress in human hepatocellular carcinoma (HCC) cells. Induction of does not trigger significant but obviously causes downregulation HCC In these cells, is enhanced by mimics and attenuated inhibitors. promoted-apoptosis p27(Kip1)- MEK/ERK-mediated cell cycle...
In this article, a fluorescence-CT dual-mode nanoprobe is successfully synthesized by making use of distearoylphosphatidylethanolamine-poly(ethylene glycol)-folate (DSPE-PEG2000-FA) and other amphiphilic molecules to coat silver sulfide (Ag2S) quantum dots (QDs) iodinated oil simultaneously. vitro experiments show that the fluorescence wavelength 1170 nm in near infrared-II region. Its size 139.6 nm, it has good dispersibility, low cellular toxicity at concentrations up 25 μg mL(-1) Ag. vivo...
Human WBSCR22 gene is involved in tumor metastasis, cell growth and invasion, however, its role chemosensitivity to antitumor agents remains unknown. In this study, we analyzed the TCGA cohort found expression of was significantly elevated human colorectal cancer (CRC) tissue. could be served as an independent risk predictor for overall survival (OS), up-regulated predict unfavorable OS CRC patients. Knockdown sensitized cells oxaliplatin vitro vivo, while overexpression led cellular...
The culture supernatant from macrophages overexpressing TRIM59 has a cytotoxic effect on melanoma, but the mechanism remains unclear.To investigate whether deletion of in affects metastatic potential melanoma cells, we polarized control and TRIM59-deficient bone marrow-derived to M2 phenotype collected respective conditioned media (CM).Exposure CM -/--M2 cultures significantly promoted migration invasion by B16-F0 B16-F10 cells.Cytokine profiling indicated ~15-fold increase TNF-α production...
Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is a valuable therapeutic strategy for wide variety of diseases. Acute graft‐versus‐host disease (aGVHD) major complication in up to 75% allo‐HSCT. The absence reliable predicative marker aGVHD onset prevents preemptive treatment and impedes widespread successful application this therapy. In study we found that after allo‐HSCT, the levels miR‐181a were reduced significantly prior aGVHD. More importantly, degree its reduction...
The potential pro-survival role of phosphatidylinositol 3-kinase (PI3K)/Akt during endoplasmic reticulum stress has been well-characterized. However, the detailed mechanisms remain largely unknown. Here, we showed that PI3K/Akt inhibition promoted stress-induced apoptosis in a glucose-regulated protein 78 (GRP78)-dependent manner. During stress, high levels Akt phosphorylation were sustained for at least 18 h HEK293 cells. Importantly, enhanced GRP78 accumulation through increasing its...
A composite nanoparticle containing QDs and Au was fabricated, it used for CT fluorescence dual mode imaging simultaneously.
Sepsis is associated with bacterial invasion and inflammation has a high mortality rate. Previous studies have demonstrated that tripartite motif 59 (TRIM59) was involved in NF-κB signaling could promote phagocytosis of macrophages, but the role TRIM59 sepsis still unknown. In our study, we found downregulated lipopolysaccharide (LPS)-stimulated bone marrow-derived macrophages (BMDMs). cecal ligation puncture (CLP) mice model, Trim59flox/floxLyz-Cre (Trim59-cKO) higher, immune cell...