A5103232553- Fossil Insects in Amber
- Lepidoptera: Biology and Taxonomy
- Plant and animal studies
- Insect and Arachnid Ecology and Behavior
- Insect-Plant Interactions and Control
- Hymenoptera taxonomy and phylogeny
- Forest Insect Ecology and Management
- Coleoptera Taxonomy and Distribution
- Endoplasmic Reticulum Stress and Disease
- Fiscal Policy and Economic Growth
- Microtubule and mitosis dynamics
- Diptera species taxonomy and behavior
- RNA regulation and disease
- Inflammasome and immune disorders
- PARP inhibition in cancer therapy
- Ubiquitin and proteasome pathways
- Glycosylation and Glycoproteins Research
- T-cell and B-cell Immunology
- Energy, Environment, Economic Growth
- Micro and Nano Robotics
- Forest Ecology and Biodiversity Studies
- Plant Parasitism and Resistance
- Regional Economic and Spatial Analysis
- Cellular transport and secretion
- Genetic and Kidney Cyst Diseases
Nanjing University of Chinese Medicine
2024
Jiangsu Provincial Hospital of Traditional Chinese Medicine
2024
Southwest Medical University
2012-2023
Soochow University
2023
First Affiliated Hospital of Henan University
2023
Zhengzhou People's Hospital
2023
Changshu No.1 People's Hospital
2023
Qingdao University
2018
Affiliated Hospital of Qingdao University
2018
Vanderbilt University
2013-2016
Abstract Despite the global impact of macrophage activation in vascular disease, underlying mechanisms remain obscure. Here we show, with proteomic analysis cell lines treated either IFNγ or IL-4, that PARP9 and PARP14 regulate activation. In primary macrophages, have opposing roles silencing induces pro-inflammatory genes STAT1 phosphorylation M(IFNγ) cells, whereas it suppresses anti-inflammatory gene expression STAT6 M(IL-4) cells. ADP-ribosylation STAT1, which is suppressed by PARP9....
It has been shown that drug resistance is extremely common in hepatocellular carcinoma (HCC) and one of the major problems HCC chemotherapy. However, detailed mechanisms remain largely unknown. We have previously endoplasmic reticulum (ER) stress involved tumorigenesis HCC. Here, we demonstrated unfolded protein response (UPR) inhibits cisplatin-induced cell apoptosis. In cells, cisplatin treatment triggers UPR, which subsequently Importantly, mild ER precondition suppresses sensitivity...
The study aims to investigate whether Long non-coding RNA (LncRNA)-UCA1 can regulate the progression of Parkinson's disease (PD) by mediating a-synuclein (SNCA) expression.PD mouse model was first constructed intraperitoneal injection MPTP. SH-SY5Y cells were treated with MPP+ for inducing in vitro PD model. Expression levels lncRNA-UCA1 and SNCA brain tissues extracted from mice MPP+-induced detected quantitative real-time polymerase chain reaction (qRT-PCR). Protein expression accessed...
CD4(+) T cells developing toward a Th2 fate express IL-4, IL-5, and IL-13 while inhibiting production of cytokines associated with other Th types, such as the Th1 cytokine IFN- γ. IL-4-producing effector give rise to long-lived memory population committed reactivation gene expression program. However, these effector-derived under Th1-skewing conditions leads IFN-γ along IL-4 in same cell. We now show that this flexibility ("plasticity") is preceded by loss repressive DNA methylation Ifng...
Abstract The capacity to achieve sufficient concentrations of Ag-specific Ab the appropriate isotypes is a critical component immunity that requires efficient differentiation and interactions B Th cells along with dendritic cells. Numerous bacterial toxins catalyze mono(ADP-ribosyl)ation mammalian proteins influence cell physiology adaptive immunity. However, little known about biological functions intracellular mono(ADP-ribosyl)transferases, such as any ability regulate responses....
Abstract c‐Met, the receptor for hepatocyte growth factor (HGF), is cell surface tyrosine kinase that controls cancer growth, survival, invasion, and metastasis. Post‐translational modification, such as glycosylation, plays an essential role in regulating function of molecules. Whether glycosylation modification regulates enzymatic properties c‐Met unknown. In this study, we investigated effect on c‐Met. We found N‐linked glycosylated protein. Both pro‐Met p145Met (the β subunit mature...
Abstract Androgen receptor (AR) signaling plays an important role in the development and progression of several liver diseases, including hepatocellular carcinoma (HCC) non‐alcoholic fatty disease (NAFLD). Dihydrotestosterone (DHT) is active metabolite major circulating androgen, testosterone. In this study, we investigated effect DHT on human cells. We found that not only induces cell cycle arrest but also initiates apoptosis androgen‐sensitive cells, such as SMMC‐7721 L02. Importantly,...
Abstract Compound C, a well‐known inhibitor of AMP‐activated protein kinase (AMPK), has been reported to exert antitumor activities in some types cells. Whether compound C can effects human cholangiocarcinoma (CCA) remains unknown. Here, we demonstrated that is potent inducer cell death and autophagy CCA Autophagy inhibitors increased the cytotoxicity towards cells, as confirmed by LDH release, PARP cleavage. It notable treatment phosphorylated Akt, sustained high levels p70S6K, decreased...
Cisplatin (CDDP) is one of the most effective anticancer agents widely used in treatment solid tumors, including ovarian cancer. It generally considered as a cytotoxic drug which kills cancer cells by causing DNA damage, and subsequently inducing apoptosis cells. However, underlying mechanisms leading to cell remain obscure. In this study, signaling pathways involved CDDP-induced were examined using CDDP-sensitive A2780s treated with CDDP (1.5-3 μg/ml) for 6h, 12h 24h. Using siRNA targeting...
Less is known about the roles of c-Jun N-terminal kinase (JNK) in cholangiocarcinoma (CCA). Here, we report that JNK exerts its oncogenic action human CCA cells, partially due to mammalian target rapamycin (mTOR) pathway regulated glucose-regulated protein 78 (GRP78) induction. In phosphorylation eukaryotic initiation factor alpha (eIF2α) results accumulation activating transcription 4 (ATF4) and GRP78 independent unfolded response (UPR). Suppression expression decreases proliferation...
Abstract Axonemal complexes in flagella are largely prepackaged the cell body. As such, one mutation often results absence of co‐assembled components and permanent motility deficiencies. For example, a Chlamydomonas mutant defective RSP4 radial spoke (RS), which is critical for bend propagation, has paralyzed that also lack paralogue RSP6 three additional RS proteins. Intriguingly, recent studies showed several strains contain mixed population swimmers cells despite their identical genetic...
Although activating transcription factor 4 (ATF4) is involved in the regulation of numerous biological functions, whether ATF4 has a direct role liver injury unknown. The aim present study was to investigate using mouse models. results revealed that protein expressed markedly higher when comparison with other tissues. Notably, tunicamycin treatment, an endoplasmic reticulum (ER) stress inducer, induced phosphorylation eukaryotic translation initiation 2α (eIF2α), but decreased levels liver....
Guanase is known as an enzyme released from the liver. Recently, cloning and sequencing of guanase gene were reported. In addition, almost simultaneously, it was reported that unknown protein binds to neuronal endocrine lethal(1)-discs large (NE-dlg), one membrane-associated guanylate kinase homologues (MAGUK) family proteins involved in synaptic connection between neurons, cloned named nedasin (NE-dlg associated protein), whose sequence identical guanase. We immunostained fresh frozen...
Objective:Evaluation of the efficacy standardized dust mite drops in sublingual immunotherapy(SLIT) for allergic rhinitis children.Method:A retrospective analysis 174 children who received SLIT with dermatophagoides farinae 2 years.These patients had been divided into two groups:monoasensitized group(n=61) and polysensitized group(n=113).The total medication score(TMS),total nasal symptoms score(TNSS) inflammatory factors were evaluated before after treatment.Result:①After treatment 2.0...