A5114119128- Suicide and Self-Harm Studies
- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Psychosomatic Disorders and Their Treatments
- Pediatric health and respiratory diseases
- Telomeres, Telomerase, and Senescence
- Homicide, Infanticide, and Child Abuse
- Radiation Therapy and Dosimetry
- Chemotherapy-induced cardiotoxicity and mitigation
- DNA Repair Mechanisms
- RNA modifications and cancer
- Substance Abuse Treatment and Outcomes
- Blood disorders and treatments
- Insect and Pesticide Research
- CRISPR and Genetic Engineering
- Radiomics and Machine Learning in Medical Imaging
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Management of metastatic bone disease
- Workplace Health and Well-being
- Glioma Diagnosis and Treatment
- Child and Adolescent Psychosocial and Emotional Development
- Advancements in Battery Materials
- Advanced Battery Technologies Research
- Homelessness and Social Issues
Dana-Farber Brigham Cancer Center
2013-2024
Brigham and Women's Hospital
2014-2024
Dana-Farber Cancer Institute
2013-2024
Harvard University
2013-2024
Baylor College of Medicine
2013-2024
Baylor Scott & White Medical Center - Temple
2024
University of Florida
2023-2024
Children's Cancer Center
2021-2023
University of Oklahoma Health Sciences Center
2018-2023
Texas Children's Hospital
2013-2023
Project Northland is an efficacy trial with the goal of preventing or reducing alcohol use among young adolescents by using a multilevel, communitywide approach.Conducted in 24 school districts and adjacent communities northeastern Minnesota since 1991, intervention targets class 1998 (sixth-grade students 1991) has been implemented for 3 years (1991 to 1994). The consists social-behavioral curricula schools, peer leadership, parental involvement/education, task force activities. Annual...
Radiotherapy-associated cardiac toxicity studies in patients with locally advanced non-small cell lung cancer (NSCLC) have been limited by small sample size and nonvalidated endpoints.The purpose of this analysis was to ascertain whether radiation dose is a predictor major adverse events (MACE) all-cause mortality (ACM).This retrospective included 748 consecutive NSCLC treated thoracic radiotherapy. Fine Gray Cox regressions were used identify predictors for MACE ACM, adjusting...
Radiotherapy accelerates coronary heart disease (CHD), but the dose to critical cardiac substructures has not been systematically studied in lung cancer.
PurposeMagnetic resonance (MR) image guidance may facilitate safe ultrahypofractionated radiation dose escalation for inoperable pancreatic ductal adenocarcinoma. We conducted a prospective study evaluating the safety of 5-fraction stereotactic MR-guided on-table adaptive therapy (SMART) locally advanced (LAPC) and borderline resectable cancer (BRPC).Methods MaterialsPatients with LAPC or BRPC were eligible this multi-institutional, single-arm, phase 2 trial after ≥3 months systemic without...
Self-mutilators' psychophysiological and subjective responses during an imaged self-mutilative act were examined. Differences in arousal to 3 control events (neutral, accidental injury, aggression) examined between self-mutilation groups (prisoner, prisoner control, nonprison control). Imagery scripts presented 4 stages; scene setting, approach, incident, consequence. Results indicated a decrease response imagery. No such was evident for nonmutilators who administered standard A lag...
Previous studies have noted that a considerable proportion of suicidal behavior is impulsive. The present study aimed to ascertain the degree which this was so and consider whether impulsive attempters differed from nonimpulsive on variables such as demographic motivational factors cireumstances surrounded occurrence act. Based criterion less than 5 minutes' premeditation, 40% two large, consecutive series were judged acted impulsively. While few differentiated between groups, depressed,...
B lymphocytes migrate among varied microenvironmental niches during diversification, selection, and conversion to memory or Ab-secreting plasma cells. Aspects of the nutrient milieu differ within these lymphoid microenvironments can influence signaling molecules such as mechanistic target rapamycin (mTOR). However, much remains be elucidated cell-intrinsic functions nutrient-sensing signal transducers that modulate cell differentiation Ab affinity. We now show amino acid-sensing mTOR complex...
Radiation therapy (RT) is a critical cancer treatment, but the existing radiation oncologist work force does not meet growing global demand. One key physician task in RT planning involves tumor segmentation for targeting, which requires substantial training and subject to significant interobserver variation.To determine whether crowd innovation could be used rapidly produce artificial intelligence (AI) solutions that replicate accuracy of an expert segmenting lung tumors targeting.We...
People who self-mutilate have been hypothesized to deficient skills in coping and problem-solving that leave them vulnerable the adoption of self-mutilation as a strategy. This hypothesis was tested using male incarcerated self-mutilators with comparisons being made non-mutilating, prisoner, non-prisoner control groups. Examination inherent resources which enable an individual effectively cope stress demonstrated depressed score for on scale measuring self-worth optimism about life....
Abstract Psychophysiological and psychological arousal patterns of individuals who self-mutilate during imaged self-mutilation were examined. Imaged control events (accidental injury, anger, neutral) compared between groups. Personalised guided imagery scripts presented in four stages: scene setting. approach, incident, consequence. Results depicted a decrease psychophysiological when participants cutting themselves. A response was not evident until after cutting. Responses to different from...
Telomeres are protected from nonhomologous end-joining (NHEJ) to avoid deleterious chromosome fusions, yet they associate with the Ku heterodimer that is principal in classical NHEJ (c-NHEJ) pathway. T-loops have been proposed inhibit Ku's association telomeric ends, thus inhibiting c-NHEJ; however, deficiencies t-loop model suggest additional mechanisms effect. We demonstrate TRF2 interacts at telomeres and via residues Ku70 helix 5 (α5), which vital for NHEJ. show interaction a mutant...
ABSTRACT The Helicobacter pylori vacuolating cytotoxin (VacA) induces the degenerative vacuolation of mammalian cells both in vitro and vivo. Here, we demonstrate that plasma membrane cholesterol is essential for by VacA. Vacuole biogenesis multiple cell lines was completely blocked when extracted selectively from using β-cyclodextrins. Moreover, increasing levels strongly potentiated VacA-induced vacuolation. In contrast, inhibiting de novo biosynthesis with lovastatin or compactin had no...
The Ku heterodimer associates with the Saccharomyces cerevisiae telomere, where it impacts several aspects of telomere structure and function. Although avidly binds DNA ends via a preformed channel, its ability to associate telomeres this mechanism could be challenged by factors known bind directly chromosome terminus. This has led uncertainty as whether itself telomeric end association is crucial for Ku's functions. To address these questions, we constructed binding–defective heterodimers...
PurposePatients with locally advanced non-small cell lung cancer (LA-NSCLC) have a high prevalence of pre-existing coronary heart disease and face excess cardiac risk after thoracic radiation therapy. We sought to assess whether statin therapy is predictor overall survival (OS) therapy.Methods MaterialsWe performed retrospective analysis 748 patients LA-NSCLC treated therapy, using Kaplan-Meier OS estimates Cox regression.ResultsStatin use among (Framingham ≥20% or disease; n = 496) was...
The aim of this study was to determine if a group individuals who exhibited phobic avoidance the workplace could be identified in terms their psychological and psychophysiological responses stressful work events. Work- phobic, work-stressed, nonstressed control groups' event neutral were compared using personalized guided imagery scripts. Each script divided into 4 stages examine participants' as they developed during course event. All participants demonstrated increased arousal response...
Parasuicide is not a single syndrome. Subtypes at present recognized are based largely on clinically derived stereotypes. When considering series of patients, the clinician unable to handle more than few attributes time. This paper describes application three very different clustering algorithms material 350 treated parasuicide patients. Mathematically, types emerge. Clinically, two these interpretable and make sense. The established are: I (n = 107) group characterized by any variables we...
Joiner's interpersonal theory of suicide postulates that occurs because thwarted belongingness and perceived burdensomeness, combined with a capability for committing suicide.The present study examines the frequency presence themes burdensomeness in notes.A total 261 notes from 1091 consecutive completed suicides Tasmania were rated burdensomeness.Contrary to theory, few found include (10.3%) (30.7%), only 4.2% had both themes. The women more often contained theme while younger...
CD4(+) T cells developing toward a Th2 fate express IL-4, IL-5, and IL-13 while inhibiting production of cytokines associated with other Th types, such as the Th1 cytokine IFN- γ. IL-4-producing effector give rise to long-lived memory population committed reactivation gene expression program. However, these effector-derived under Th1-skewing conditions leads IFN-γ along IL-4 in same cell. We now show that this flexibility ("plasticity") is preceded by loss repressive DNA methylation Ifng...
Within the information technology (IT) industry, best practices and standards are constantly evolving being refined. In contrast, computer utilized within healthcare industry often evolves at a glacial pace, with reduced opportunities for justified innovation. Although use of timely refreshes an enterprise's overall stack can be costly, thoughtful adoption select technologies demonstrated return on investment very effective in increasing productivity same time, reducing burden maintenance...
TIN2 is central to the shelterin complex, linking telomeric proteins TRF1 and TRF2 with TPP1/POT1. Mutations in TINF2, which encodes TIN2, that are found dyskeratosis congenita (DC) result very short telomeres cluster a region shared by two isoforms, TIN2S (short) TIN2L (long). Here we show TIN2L, but not TIN2S, phosphorylated. interacts more than both DC phosphorylation promote this enhanced interaction. The binding of affected TRF2-F120, also required for TRF2's interaction end processing...