A5083957292- Immune Response and Inflammation
- PI3K/AKT/mTOR signaling in cancer
- Immune Cell Function and Interaction
- NF-κB Signaling Pathways
- T-cell and B-cell Immunology
- Genomics, phytochemicals, and oxidative stress
- Ubiquitin and proteasome pathways
- Mast cells and histamine
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Cytokine Signaling Pathways and Interactions
- Endoplasmic Reticulum Stress and Disease
- Cell Adhesion Molecules Research
- Histone Deacetylase Inhibitors Research
- Cancer Mechanisms and Therapy
- Respiratory viral infections research
- Air Quality and Health Impacts
- RNA Interference and Gene Delivery
- Protein Kinase Regulation and GTPase Signaling
- Genetic factors in colorectal cancer
- Synthesis and biological activity
- Redox biology and oxidative stress
- Asthma and respiratory diseases
- Cancer Immunotherapy and Biomarkers
- interferon and immune responses
Ewha Womans University
2025
Hallym University
2014-2023
Seoul National University
2005-2020
Research Institute for Bioscience and Biotechnology
2019-2020
Seoul National University Bundang Hospital
2016-2019
Korea Research Institute of Bioscience and Biotechnology
2019
CSL (United Kingdom)
2018
Vanderbilt University Medical Center
2018
Yonsei University
2001-2017
The University of Texas MD Anderson Cancer Center
2016
Other SectionsAbstractINTRODUCTIONFUNCTIONAL DIVERSITY OF MACROPHAGESIMMUNOMETABOLISM MACROPHAGESMETABOLIC DISEASES AND MACROPHAGESCONCLUDING REMARKSACKNOWLEDGEMENTSCONFLICTS INTERESTFiguresTableReferences
Notch plays critical roles in both cell fate decisions and tumorigenesis. receptor engagement initiates signaling cascades that include a phosphatidylinositol 3-kinase/target of rapamycin (TOR) pathway. Mammalian TOR (mTOR) participates two distinct biochemical complexes, mTORC1 mTORC2, the relationship between mTORC2 physiological outcomes dependent on is unknown. In this study, we report contributions to thymic T-cell acute lymphoblastic leukemia (T-ALL) driven by Notch. Conditional...
Background Anti-programmed cell death ligand 1 (PD-L1)/programmed antibodies have shown clinical activity in platinum-treated metastatic urothelial carcinoma, resulting regulatory approval of several agents, including avelumab (anti-PD-L1). We report ≥2-year follow-up data for treatment and exploratory subgroup analyses patients with carcinoma. Methods Patients previously treated advanced/metastatic pooled from two cohorts the phase Ib JAVELIN Solid Tumor trial, received 10 mg/kg every 2...
B lymphocytes migrate among varied microenvironmental niches during diversification, selection, and conversion to memory or Ab-secreting plasma cells. Aspects of the nutrient milieu differ within these lymphoid microenvironments can influence signaling molecules such as mechanistic target rapamycin (mTOR). However, much remains be elucidated cell-intrinsic functions nutrient-sensing signal transducers that modulate cell differentiation Ab affinity. We now show amino acid-sensing mTOR complex...
Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates diverse array cellular processes, including cell growth, survival, metabolism, and cytoskeleton dynamics. mTOR functions in two distinct complexes, mTORC1 mTORC2, whose activities substrate specificities are regulated by complex specific cofactors, Raptor Rictor, respectively. Little known regarding the relative contribution versus mTORC2 vascular endothelial cells. Using mouse models or Rictor gene targeting,...
Matrix metalloproteinase-9 (MMP-9) plays a pivotal role in the turnover of extracellular matrix (ECM) and migration normal tumor cells response to physiologic numerous pathologic conditions. Here, we show that transcription MMP-9 gene is induced by lipopolysaccharide (LPS) stimulation macrophage lineage (RAW 264.7 cells). We provide evidence NF-<TEX>$\kappa$</TEX>B binding site contributes its expression LPS-signaling pathway, since mutation promoter leads dramatic reduction activation. In...
The stimulation of Toll-like receptors (TLRs) on macrophages by pathogen-associated molecular patterns (PAMPs) results in the activation intracellular signaling pathways that are required for initiating a host immune response. Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 mitogen-activated protein kinase (MAPK) activated rapidly response to TLR coordinate effective responses pathogen invasion. In this study, we analyzed role p38-dependent kinases MK2/3 Akt show lipopolysaccharide...
Cancer genome sequencing efforts recently identified EPHA3, which encodes the EPHA3 receptor tyrosine kinase, as one of most frequently mutated genes in lung cancer. Although kinase mutations often drive oncogenic conversion and tumorigenesis, potential cancer remains unknown. We used immunoprecipitation, western blotting, assays to determine activity signaling mutant receptors. A mutation-associated gene signature was generated from large dataset, mapped another training dataset with...
T cell receptor (TCR) signals can elicit full activation with acquisition of effector functions or a state anergy. Here, we ask whether microRNAs affect the interpretation TCR signaling. We find that Dicer-deficient CD4 cells fail to correctly discriminate between activating and anergy-inducing stimuli produce IL-2 in absence co-stimulation. Excess production by was sufficient override anergy induction WT restore inducible Foxp3 expression Il2-deficient cells. Phosphorylation Akt on S473 S6...
Oxidative stress plays an important role in the progression of various neuronal diseases including ischemia. Heat shock protein 22 (HSP22) is known to protect cells against oxidative stress. However, protective effects and mechanisms HSP22 hippocampal under remain unknown. In this study, we determined whether protects hydrogen peroxide (H2O2)-induced HT-22 using Tat-HSP22 fusion protein. We found that transduced into H2O2-induced cell death, stress, DNA damage were significantly reduced by...
To examine the current practices relating to do-not-resuscitate (DNR) orders for terminal patients with cancer at teaching hospitals in Korea.The records of 387 deaths from January 1 December 31, 2005 four centers were identified and reviewed assess DNR delineation. Basic demographics, circumstances surrounding establishment directive, percentage populations, time interval between consent death evaluated.An order was obtained 296 (76%) a total patients. All consents made physician family,...
CD4(+) T cells developing toward a Th2 fate express IL-4, IL-5, and IL-13 while inhibiting production of cytokines associated with other Th types, such as the Th1 cytokine IFN- γ. IL-4-producing effector give rise to long-lived memory population committed reactivation gene expression program. However, these effector-derived under Th1-skewing conditions leads IFN-γ along IL-4 in same cell. We now show that this flexibility ("plasticity") is preceded by loss repressive DNA methylation Ifng...
Purpose: Profibrotic activation is essential for pterygium development. In this study, we investigated the role of mechanistic target rapamycin (mTOR) in regulating TGF-β1-induced myofibroblastic responses human fibroblasts (HPFs) and elucidated relative contributions mTOR signaling components. Methods: HPFs were pretreated with inhibitors Torin2, expression profibrotic markers, including α-smooth muscle actin (α-SMA) fibronectin, was evaluated. RNA interference-based approaches targeting...
Glutathione S-transferase alpha 2 (GSTA2), a member of the glutathione family, plays role cellular detoxification against oxidative stress. Although stress is related to ischemic injury, GSTA2 ischemia has not been elucidated. Thus, we studied whether prevents injury by using PEP-1-GSTA2 protein which cell-permeable transduction domain. We revealed that transduced into HT-22 cells and markedly protected cell death via inhibition reactive oxygen species (ROS) production DNA damage induced...