A5016238643- Cancer Immunotherapy and Biomarkers
- Bladder and Urothelial Cancer Treatments
- Lung Cancer Treatments and Mutations
- Data-Driven Disease Surveillance
- Bioinformatics and Genomic Networks
- Polyomavirus and related diseases
- Gene expression and cancer classification
- Genetic Associations and Epidemiology
- Urinary and Genital Oncology Studies
- Lung Cancer Research Studies
- Head and Neck Cancer Studies
- Complex Network Analysis Techniques
- Data Analysis with R
- Opinion Dynamics and Social Influence
- Multiple and Secondary Primary Cancers
- Oral health in cancer treatment
- Salmonella and Campylobacter epidemiology
- COVID-19 epidemiological studies
- Renal cell carcinoma treatment
- Food Safety and Hygiene
- Advanced Statistical Process Monitoring
- Colorectal Cancer Treatments and Studies
- Ferroptosis and cancer prognosis
- Cancer-related cognitive impairment studies
- Statistical Methods in Clinical Trials
Ono Pharmaceutical (United States)
2018-2025
Research & Development Institute
2020-2025
Merck (Germany)
2020-2021
Boston University
2016-2021
University of Göttingen
2013-2017
Ludwig-Maximilians-Universität München
2010-2011
Complaints of cognitive dysfunction are frequent among cancer patients. Many studies have identified neuropsychological compromise associated with and therapy; however, the was not related to self-reported dysfunction. In this prospective study, authors examined if confounding factors masked an underlying association self-perceived function actual performance. Determinants were investigated.Self-perceived performance assessed before treatment, at end 1 year after baseline in 101 breast...
Background Anti-programmed cell death ligand 1 (PD-L1)/programmed antibodies have shown clinical activity in platinum-treated metastatic urothelial carcinoma, resulting regulatory approval of several agents, including avelumab (anti-PD-L1). We report ≥2-year follow-up data for treatment and exploratory subgroup analyses patients with carcinoma. Methods Patients previously treated advanced/metastatic pooled from two cohorts the phase Ib JAVELIN Solid Tumor trial, received 10 mg/kg every 2...
A prognostic model for overall survival of post-platinum patients with metastatic urothelial carcinoma receiving PD-1/PD-L1 inhibitors is necessary as existing models were constructed in the chemotherapy setting.Patient level data used from phase I/II trials evaluating PD-L1 following platinum based carcinoma. The derivation set consisted 2 atezolizumab (405). Two that evaluated avelumab (242) and durvalumab (198) comprised validation sets. Cox regression analyses association candidate...
Background Patients treated with immune checkpoint inhibitors (ICIs) may experience pseudoprogression, which can be classified as progressive disease (PD) by Response Evaluation Criteria in Solid Tumors (RECIST) V.1.1 and could lead to inappropriate treatment discontinuation. Immune-response criteria were developed better capture novel response patterns seen ICIs. Methods We pooled data from 1765 patients 12 types of advanced solid tumors avelumab (an anti-programmed death ligand 1 (PD-L1)...
The key challenge during food-borne disease outbreaks, e.g. the 2011 EHEC/HUS outbreak in Germany, is design of efficient mitigation strategies based on a timely identification outbreak's spatial origin. Standard public health procedures typically use case-control studies and tracings along food shipping chains. These methods are time-consuming suffer from biased data collected slowly patient interviews. Here we apply recently developed, network-theoretical method to identify origin...
Avelumab (anti-PD-L1) is an approved anticancer treatment for several indications. The JAVELIN Gastric 100 phase III trial did not meet its primary objective of demonstrating superior overall survival (OS) with avelumab maintenance versus continued chemotherapy in patients advanced gastric cancer/gastroesophageal junction cancer; however, the OS rate was numerically higher at timepoints after 12 months. Machine learning (random forests, SIDEScreen, and variable-importance assessments) used...
Biological pathways provide rich information and biological context on the genetic causes of complex diseases. The logistic kernel machine test integrates prior knowledge in order to analyze data from genome-wide association studies (GWAS). In this study, converts genomic 2 individuals into a quantitative value reflecting their similarity. With selection kernel, one implicitly chooses effect model. Like many other pathway methods, none available kernels accounts for topological structure or...
Background Adverse events (AEs) of special interest that arise during treatment with immune checkpoint inhibitors, including immune-related AEs (irAEs), have been reported to be associated improved clinical outcomes. We analyzed patients treated avelumab from the JAVELIN Solid Tumor and Merkel 200 trials, examining association between efficacy while adjusting for confounding factors such as duration event order. Methods safety data 1783 programmed death ligand 1 inhibitor who were enrolled...
An addendum of the ICH E9 guideline on Statistical Principles for Clinical Trials was released in November 2019 introducing estimand framework. This new framework aims to align trial objectives and statistical analyses by requiring a precise definition inferential quantity interest, that is, estimand. explicitly accounts intercurrent events, such as switching anticancer therapies analysis overall survival (OS), gold standard oncology. Traditionally, OS confirmatory studies is analyzed using...
In infectious disease epidemiology, statistical methods are an indispensable component for the automated detection of outbreaks in routinely collected surveillance data. So far, methodology this area has been largely frequentist nature and increasingly taking inspiration from process control. The present work is concerned with strengthening Bayesian thinking field. We extend widely used approach Farrington et al. Heisterkamp to a modern framework within time series decomposition context....
Summary The correct identification of the source a propagation process is crucial in many research fields. As specific application, we consider estimation delays public transportation networks. We propose two approaches: an effective distance median and backtracking method. former based on structurally generic distance-based approach for infectious disease origins, latter specifically designed delay propagation. examine performance both methods simulation studies application to German...
In 2011, a large outbreak of entero-hemorrhagic E. coli (EHEC) and hemolytic uremic syndrome (HUS) occurred in Germany. The City Hamburg was the first focus epidemic had highest incidences among all 16 Federal States this article, we present epidemiological characteristics notification data. Evaluating epicurves retrospectively, found that signal outbreak, which form HUS case cluster, received by local health authorities when already 99 EHEC 48 patients experienced their symptoms. However,...
The analysis of genome-wide association studies (GWAS) benefits from the investigation biologically meaningful gene sets, such as gene-interaction networks (pathways). We propose an extension to a successful kernel-based pathway approach by integrating kernel functions into powerful algorithmic framework for variable selection, enable multiple pathways simultaneously. employ genetic similarity kernels logistic machine test (LKMT) base-learners in boosting algorithm. A model explain...
We investigate the source detection problem in epidemiology, which is one of most important issues for control epidemics. Mathematically, we reformulate as identifying relevant component a multivariate Gaussian mixture model. Focusing on study cholera and diseases with similar modes transmission, calibrate parameters our model using human mobility networks within stochastic, spatially explicit epidemiological waterborne disease. Furthermore, adopt Bayesian perspective, so that prior...
The JAVELIN Lung 200 phase 3 trial did not meet its primary endpoint of improving overall survival (OS) with avelumab vs docetaxel in patients platinum-treated PD-L1+ NSCLC. We report post hoc analyses assessing the effects subsequent immune checkpoint inhibitor (ICI) treatment on OS.Patients stage IIIB/IV NSCLC progressed following platinum-doublet therapy were randomized to receive or docetaxel. OS was analyzed population (≥1% tumor cells) and full analysis set (PD-L1+ PD-L1-). Effects ICI...
Avelumab first-line (1 L) maintenance is a standard of care for advanced urothelial carcinoma (aUC) based on the JAVELIN Bladder 100 phase 3 trial, which showed that avelumab 1 L + best supportive (BSC) significantly prolonged overall survival (OS) and progression-free (PFS) vs BSC alone in patients who were progression free after receiving platinum-containing chemotherapy. Here, we comprehensively screened trial datasets to identify prognostic factors define subpopulations with longer or...
4552 Background: A prognostic model for overall survival (OS) of metastatic urothelial carcinoma (mUC) was previously reported in the setting post-platinum atezolizumab (Pond GR, GU ASCO 2018). This limited by employing only treated patients (pts), small size validation dataset and unclear applicability to other PD-1/L1 inhibitors. Hence, we constructed a robust utilizing combined cohort as discovery used 2 separate datasets comprised avelumab or durvalumab pts. Methods: The consisted pt...
Background: This study examined patients with advanced non-small-cell lung cancer who received long-term avelumab (anti-PD-L1) in a large phase Ib trial (JAVELIN Solid Tumor). Methods: Patients receiving >2 years of were reviewed and exploratory descriptive analyses conducted. Results: Individuals varying baseline characteristics had up to 6 reviewed. Overall, 37/340 (10.9%) ≥2 treatment; this subgroup, best response was complete 5.4%, partial 59.5% stable disease 29.7%; 51.4% continued...