A5018945181- Cancer Immunotherapy and Biomarkers
- Bladder and Urothelial Cancer Treatments
- Virus-based gene therapy research
- Poxvirus research and outbreaks
- Ubiquitin and proteasome pathways
- Enzyme Structure and Function
- Medical Research and Treatments
- Computational Drug Discovery Methods
- Colorectal Cancer Treatments and Studies
- Bacteriophages and microbial interactions
- Alzheimer's disease research and treatments
- Metabolism and Genetic Disorders
- Tuberculosis Research and Epidemiology
- Fungal and yeast genetics research
- Genomics and Chromatin Dynamics
- Esophageal Cancer Research and Treatment
- Prion Diseases and Protein Misfolding
- RNA Interference and Gene Delivery
- Pancreatic and Hepatic Oncology Research
- Pharmacological Effects of Natural Compounds
- Cancer Research and Treatments
- Steroid Chemistry and Biochemistry
- CAR-T cell therapy research
- Inflammatory Bowel Disease
- Toxoplasma gondii Research Studies
Wuhan University
2012-2024
Hubei University of Chinese Medicine
2024
University of Cambridge
2018-2024
Huazhong University of Science and Technology
2024
Hubei Cancer Hospital
2024
Beijing University of Chinese Medicine
2022
Bronglais General Hospital
2021
St Vincents Institute of Medical Research
2012-2021
Shandong Academy of Agricultural Sciences
2018-2021
Shandong Normal University
2021
Abstract The utility of circulating tumor DNA (ctDNA) as a biomarker in patients with advanced cancers receiving immunotherapy is uncertain. We therefore analyzed pretreatment (n = 978) and on-treatment 171) ctDNA samples across 16 advanced-stage types from three phase I/II trials durvalumab (± the anti-CTLA4 therapy tremelimumab). Higher variant allele frequencies (VAF) were associated poorer overall survival (OS) other known prognostic factors, but not objective response, suggesting role...
Mycobacterium tuberculosis is able to use a variety of carbon sources in vivo and current knowledge suggests that cholesterol used as source during infection. The catabolized both an energy (ATP generation) precursor molecules for the synthesis complex methyl-branched fatty acids. In previous studies, we described TetR-type transcriptional repressor, kstR , controls expression number genes involved catabolism. this study, describe second which call kstR2. We knocked gene out smegmatis...
A prognostic model for overall survival of post-platinum patients with metastatic urothelial carcinoma receiving PD-1/PD-L1 inhibitors is necessary as existing models were constructed in the chemotherapy setting.Patient level data used from phase I/II trials evaluating PD-L1 following platinum based carcinoma. The derivation set consisted 2 atezolizumab (405). Two that evaluated avelumab (242) and durvalumab (198) comprised validation sets. Cox regression analyses association candidate...
Background Limited data exist on potential clinical benefit with anti-programmed cell death ligand-1 (PD-L1) retreatment in patients who stop initial therapy for reasons other than disease progression or toxicity and develop while off treatment. Patients methods NCT01693562 was a phase I/II study evaluating durvalumab monotherapy advanced solid tumors. benefiting from treatment were taken at 1 year per protocol prospectively followed. At progression, they eligible retreatment. Outcomes...
Cholesterol can be a major carbon source for Mycobacterium tuberculosis during infection, both at an early stage in the macrophage phagosome and later within necrotic granuloma. KstR is highly conserved TetR family transcriptional repressor that regulates large set of genes responsible cholesterol catabolism. Many this regulon, including kstR, are either induced infection or essential survival M. vivo. In study, we identified two ligands KstR, which CoA thioester metabolites with four intact...
Histone deacetylases (HDACs) regulate gene expression and innate immunity. Previously, we showed that HDAC5 is degraded during Vaccinia virus (VACV) infection a restriction factor for VACV herpes simplex type 1. Here, report promotes interferon regulatory 3 (IRF3) activation downstream of Toll-IL-1 receptor (TIR) domain-containing adaptor molecule-1 or Sendai virus-mediated stimulation without requiring HDAC activity. Loss HDAC5-mediated IRF3 restored by re-introduction but not HDAC1 HDAC4....
In alphaT3-1 mouse anterior pituitary gonadotropes, chronic activation of gonadotropin-releasing hormone (GnRH) receptors causes inositol 1,4,5-trisphosphate (InsP(3)) receptor down-regulation (Willars, G. B., Royall, J. E., Nahorski, S. R., El-Gehani, F., Everest, H. and McArdle, C. A. (2001) Biol. Chem. 276, 3123-3129). the current study, we sought to define mechanism behind this adaptive response. We show that GnRH induces a rapid dramatic increase in InsP(3) polyubiquitination proteasome...
The morphogenesis of vaccinia virus (VACV, family
Vaccinia virus (VACV) is a large DNA that encodes scores of proteins modulate the host immune response. VACV protein C4 one such immunomodulator known to inhibit activation both NF-κB signaling cascade and DNA-PK-mediated sensing pathway. Here, we show N-terminal region C4, which neither inhibits nor mediates interaction with DNA-PK, still contributes virulence. Furthermore, this domain interacts directly high affinity C-terminal filamin B (FLNB). FLNB actin-binding stabilizes F-actin...
Phosphoinositide 3-kinase (PI3K) inhibitors have shown synergistic anticancer effects with endocrine therapy against ER+/PIK3CA-mutated breast cancer. PI3K for cancer are becoming more common. There is an increasing need to understand their cardiac adverse events. In this report, we describe the features of near-fatal mixed arrhythmias in a patient who was undergoing phase Ib clinical study PI3Kα inhibitor fulvestrant. Subsequently, survived by cardiopulmonary resuscitation and therefore did...
As individuals age, they commonly experience reduced physical activity and cognitive decline. While evidence, there is limited trajectory research on their concurrent progression interrelation in over 55 years old.
TAF9 is a TATA-binding protein associated factor (TAF) conserved from yeast to humans and shared by two transcription coactivator complexes, TFIID SAGA. The essentiality of the TAFs has made it difficult ascertain their roles in SAGA function. Here we performed genomic synthetic genetic array analysis using temperature-sensitive allele as query. Results this experiment showed that interacts genetically with: (1) genes for multiple complexes predominantly involving Mediator, chromatin...
In Saccharomyces cerevisiae, transcription of several drug transporter genes, including the major gene PDR5, has been shown to peak during mitosis. The significance this observation, however, remains unclear. PDR1 encodes primary activator multiple genes in S. PDR5. Here, we show that synchronized and pdr1-3 (multidrug resistant) strains, cellular efflux a known substrate ATP-binding-cassette transporters, doxorubicin (a fluorescent anticancer drug), is highest mitosis when PDR5 peaks. A...
Serine/threonine kinases (STKs) play important roles in prokaryotic cellular functions such as growth, differentiation, and secondary metabolism. When the external environment changes, prokaryotes rely on signal transduction systems, including STKs that quickly sense these changes alter gene expression to induce appropriate metabolic changes. In this study, we examined of STK genes spkD spkG fatty acid biosynthesis unicellular cyanobacterium Synechocystis sp. PCC6803, using targeted...
Abstract Background In patients (pts) with HER2+ (immunohistochemistry [IHC] 3+ or IHC 2+/in situ hybridization [ISH]+) metastatic breast cancer (mBC), HER2-targeted therapies have greatly improved survival. However, for pts HER2-low mBC (IHC 1+ 2+/ISH−), there are no approved HER2-directed therapies. hormone receptor (HR)+, whose disease progresses on standard first-line treatment (endocrine therapy [ET] and CDK4/6 inhibitors), median progression-free survival (PFS) continued ET alone is ≈...